The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The Structure and Function of Myelin Oligodendrocyte Glycoprotein
Abstract
Abstract : Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor component of CNS myelin whose function remains relatively unknown. As MOG is an autoantigen capable of producing a demyelinating multiple sclerosis‐like disease in mice and rats, much of the research directed toward MOG has been immunological in nature. Although the function of MOG is yet to be elucidated, there is now a relatively large amount of biochemical and molecular data relating to MOG. Here we summarize this information and include our recent findings pertaining to the cloning of the marsupial MOG gene. On the basis of this knowledge we suggest three possible functions for MOG : (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. Given that antibodies to MOG and to the myelin‐specific glycolipid galactocerebroside (Gal‐C) both activate the same signaling pathway leading to MBP degradation, we propose that there is a direct interaction between the membrane‐associated regions of MOG and Gal‐C. Such an interaction may have important consequences regarding the membrane topology and function of both molecules. Finally, we examine how polymorphisms and/or mutations to the MOG gene could contribute to the pathogenesis of multiple sclerosis.
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Cites
Protein Lipidation in Cell Signaling
Casey, P. J. (1995) · Science · doi:10.1126/science.7716512 · Cited by 774
Korb, L. C., & Ahearn, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4525 · Cited by 657
Brunner, C., Lassmann, H., Waehneldt, T. V., Matthieu, J., & Linington, C. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb10930.x · Cited by 409
Myelination in the absence of myelin-associated glycoprotein
Li, C., Tropak, M. B., Gerlai, R., Clapoff, S., Abramow-Newerly, W., Trapp, B., Peterson, A., & Roder, J. (1994) · Nature · doi:10.1038/369747a0 · Cited by 380
A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody
Linnington, C., Webb, M., & Woodhams, P. L. (1984) · Journal of Neuroimmunology · doi:10.1016/0165-5728(84)90064-x · Cited by 321
Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis
Bernard, C. C. A., Johns, T. G., Slavin, A., Ichikawa, M., Ewing, C., Liu, J., & Bettadapura, J. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050092 · Cited by 270
Self-citationMyelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily
Gardinier, M. V., Amiguet, P., Linington, C., & Matthieu, J. ‐. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330123 · Cited by 244
Pham-Dinh, D., Mattei, M. G., Nussbaum, J. L., Roussel, G., Pontarotti, P., Roeckel, N., Mather, I. H., Artzt, K., Lindahl, K. F., & Dautigny, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7990 · Cited by 220
Johns, T. G., Kerlero de Rosbo, N., Menon, K. K., Abo, S., Gonzales, M. F., & Bernard, C. C. A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5536 · Cited by 181
Self-citationMyelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation
Scolding, N. J., Frith, S., Linington, C., Morgan, B. P., Campbell, A. K., & Compston, D. A. S. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90014-3 · Cited by 142
Cited by
Jarius, S., Paul, F., Weinshenker, B. G., Levy, M., Kim, H. J., & Wildemann, B. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0214-9 · Cited by 478
The spectrum of MOG autoantibody-associated demyelinating diseases
Reindl, M., Di Pauli, F., Rostásy, K., & Berger, T. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.118 · Cited by 375
Höftberger, R., Guo, Y., Flanagan, E. P., Lopez-Chiriboga, A. S., Endmayr, V., Hochmeister, S., Joldic, D., Pittock, S. J., Tillema, J. M., Gorman, M., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02132-y · Cited by 369
Myelin Proteomics: Molecular Anatomy of an Insulating Sheath
Jahn, O., Tenzer, S., & Werner, H. B. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8071-2 · Cited by 329
On the molecular architecture of myelinated fibers
Arroyo, E. J., & Scherer, S. S. (2000) · Histochemistry and Cell Biology · doi:10.1007/s004180050001 · Cited by 252
Metadata
- Authors
- Johns, T. G., & Bernard, C. C. A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1999-01
- Volume
- 72
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2083198066
- Cited by
- 294
- References
- 44
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
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