The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up‐Regulation of the Glutathione Synthesis
Abstract
Abstract: We examined the effects of oxidative stress on rat cultured mesencephalic neurons and glial cells. Glial cells were more resistant to 6‐hydroxydopamine (6‐OHDA) and H 2 O 2 toxicity than neurons. In glial cells, incubation with 6‐OHDA and H 2 O 2 induced a significant increase in the expression of γ‐glutamylcysteine synthetase (the rate‐limiting enzyme in glutathione synthesis) mRNA, which correlated well with increased TPA‐response element (TRE)‐binding activity. Furthermore, a subsequent elevation in cellular total glutathione content was also observed. In neurons, both agents decreased TRE‐binding activity, and these cells failed to up‐regulate the glutathione synthesis. We also examined the mechanisms of the neuroprotective effects of glial cells using a glia conditioned medium. Neurons maintained in glia conditioned medium up‐regulated the level of TRE‐binding activity, γ‐glutamylcysteine synthetase mRNA expression, and total glutathione content in response to 6‐OHDA or H 2 O 2, and became more resistant to both agents than cells maintained in a normal medium. Neurons maintained in normal medium failed to up‐regulate the glutathione synthesis. Our results suggest that transcriptional up‐regulation of glutathione synthesis in glial cell appears to mediate brain glial cell resistance against oxidative stress, and that glial cells protect neurons via transcriptional up‐regulation of the antioxidant system.
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Cites
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149
Cited by
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702
Astrocyte activation and reactive gliosis
Pekny, M., & Nilsson, M. (2005) · Glia · doi:10.1002/glia.20207 · Cited by 1,611
Antioxidant Therapy in Acute Central Nervous System Injury: Current State
Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568
Mosharov, E., Cranford, M. R., & Banerjee, R. (2000) · Biochemistry · doi:10.1021/bi001088w · Cited by 459
Diabetic neuropathy and oxidative stress
Pop-Busui, R., Sima, A., & Stevens, M. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.625 · Cited by 286
Metadata
- Authors
- Iwata‐Ichikawa, E., Kondo, Y., Miyazaki, I., Asanuma, M., & Ogawa, N.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1999-06
- Volume
- 72
- Issue
- 6
- Pages
- 2334-2344
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2039114029
- Cited by
- 173
- References
- 3
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Iwata‐Ichikawa, E., Kondo, Y., Miyazaki, I., Asanuma, M., & Ogawa, N. (1999). Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up‐Regulation of the Glutathione Synthesis. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1999.0722334.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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