The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Chronic ▵9‐Tetrahydrocannabinol Treatment Produces a Time‐Dependent Loss of Cannabinoid Receptors and Cannabinoid Receptor‐Activated G Proteins in Rat Brain
Abstract
Abstract : Chronic treatment of rats with ▵9‐tetrahydrocannabinol (▵9‐THC) results in tolerance to its acute behavioral effects. In a previous study, 21‐day ▵9‐THC treatment in rats decreased cannabinoid activation of G proteins in brain, as measured by in vitro autoradiography of guanosine‐5′‐O‐(3‐[35 S]thiotriphosphate) ([35 S]GTPγS) binding. The present study investigated the time course of changes in cannabinoid‐stimulated [35 S]GTPγS binding and cannabinoid receptor binding in both brain sections and membranes, following daily ▵9‐THC treatments for 3, 7, 14, and 21 days. Autoradiographic results showed time‐dependent decreases in WIN 55212‐2‐stimulated [35 S]GTPγS and [3 H]WIN 55212‐2 binding in cerebellum, hippocampus, caudate‐putamen, and globus pallidus, with regional differences in the rate and magnitude of down‐regulation and desensitization. Membrane binding assays in these regions showed qualitatively similar decreases in WIn 55212‐2‐stimulated [35 S]GTPγS binding and cannabinoid receptor binding (using [3 H]SR141716A), and demonstrated that decreases in ligand binding were due to decreases in maximal binding values, and not ligand affinities. These results demonstrated that chronic exposure to ▵9‐THC produced time‐dependent and region‐specific down‐regulation and desensitization of brain cannabinoid receptors, which may represent underlying biochemical mechanisms of tolerance to cannabinoids.
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Citations
Cites
Molecular characterization of a peripheral receptor for cannabinoids
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Structure of a cannabinoid receptor and functional expression of the cloned cDNA
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Determination and characterization of a cannabinoid receptor in rat brain
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“Cannabinoid compounds exert their CNS effects by binding to brain cannabinoid receptors (Compton et al., 1993) to activate Giand Go-type G proteins (Howlett et al., 1986; Devane et al., 1988).”
Cited by
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Cannabinoid physiology and pharmacology: 30 years of progress
Howlett, A. C., Breivogel, C. S., Childers, S. R., Deadwyler, S. A., Hampson, R. E., & Porrino, L. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.030 · Cited by 608
Self-citationHirvonen, J., Goodwin, R. S., Li, C.-T., Terry, G. E., Zoghbi, S. S., Morse, C., Pike, V. W., Volkow, N. D., Huestis, M. A., & Innis, R. B. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.82 · Cited by 587
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The Role of cannabinoids in neuroanatomic alterations in cannabis users.
Lorenzetti, V., Solowij, N., & Yücel, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.013 · Cited by 208
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Metadata
- Authors
- Breivogel, C. S., Childers, S. R., Deadwyler, S. A., Hampson, R. E., Vogt, L. J., & Sim‐Selley, L. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1999-12
- Volume
- 73
- Issue
- 6
- Pages
- 2447-2459
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2004142971
- Cited by
- 273
- References
- 3
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
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