The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS
Open accessAbstract
Abstract : Differential display of mRNA was used to identify concordant changes in gene expression induced by two mood‐stabilizing agents, lithium and valproate (VPA). Both treatments, on chronic administration, increased mRNA levels of the transcription factor polyomavirus enhancer‐binding protein (PEBP) 2β in frontal cortex (FCx). Both treatments also increased the DNA binding activity of PEBP2αβ and robustly increased the levels of bcl‐2 (known to be transcriptionally regulated by PEBP2) in FCx. Immunohistochemical studies revealed a marked increase in the number of bcl‐2‐immunoreactive cells in layers 2 and 3 of FCx. These novel findings represent the first report of medication‐induced increases in CNS bcl‐2 levels and may have implications not only for mood disorders, but also for long‐term treatment of various neurodegenerative disorders.
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Cited by
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182
Self-citationOxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
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Neuronal plasticity and survival in mood disorders
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Metadata
- Authors
- Chen, G., Zeng, W., Yuan, P., Huang, L., Jiang, Y., Zhao, Z., & Manji, H. K.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1999-02
- Volume
- 72
- Issue
- 2
- Pages
- 879-882
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2024709318
- Cited by
- 494
- References
- 23
- FWCI
- 18.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, G., Zeng, W., Yuan, P., Huang, L., Jiang, Y., Zhao, Z., & Manji, H. K. (1999). The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1999.720879.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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