The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Characterization of Apelin, the Ligand for the APJ Receptor
Abstract
Abstract: The apelin peptide was recently discovered and demonstrated to be the endogenous ligand for the G protein‐coupled receptor, APJ. A search of the GenBank databases retrieved a rat expressed sequence tag partially encoding the preproapelin sequence. The GenBank search also revealed a human sequence on chromosome Xq25‐26.1, containing the gene encoding preproapelin. We have used the rat sequence to screen a rat brain cDNA library to obtain a cDNA encoding the full‐length open reading frame of rat preproapelin. This cDNA encoded a protein of 77 amino acids, sharing an identity of 82% with human preproapelin. Northern and in situ hybridization analyses revealed both human and rat apelin and APJ to be expressed in the brain and periphery. Both sequence and mRNA expression distribution analyses revealed similarities between apelin and angiotensin II, suggesting they that share related physiological roles. A synthetic apelin peptide was injected intravenously into male Wistar rats, resulting in immediate lowering of both systolic and diastolic blood pressure, which persisted for several minutes. Intraperitoneal apelin injections induced an increase in drinking behavior within the first 30 min after injection, with a return to baseline within 1 h.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Cited by
Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity
Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1427 · Cited by 910
Taheri, S., Murphy, K., Cohen, M., Sujkovic, E., Kennedy, A., Dhillo, W., Dakin, C., Sajedi, A., Ghatei, M., & Bloom, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6575 · Cited by 314
Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261
Hall, E., Volkov, P., Dayeh, T., Esguerra, J. L. S., Salö, S., Eliasson, L., Rönn, T., Bacos, K., & Ling, C. (2014) · Genome Biology · doi:10.1186/s13059-014-0522-z · Cited by 249
Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes
Wei, L., Hou, X., & Tatemoto, K. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.08.003 · Cited by 127
Metadata
- Authors
- Lee, D. K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A. P., Liu, Y., Osmond, D. H., George, S. R., & O'Dowd, B. F.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2000-01
- Volume
- 74
- Issue
- 1
- Pages
- 34-41
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2075714512
- Cited by
- 682
- References
- 2
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, D. K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A. P., Liu, Y., Osmond, D. H., George, S. R., & O'Dowd, B. F. (2000). Characterization of Apelin, the Ligand for the APJ Receptor. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2000.0740034.x
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