The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Methamphetamine Rapidly Decreases Vesicular Dopamine Uptake
Abstract
Abstract: Vesicular sequestration is important in the regulation of cytoplasmic concentrations of monoamines such as dopamine. Moreover, recent evidence suggests that increases in cytoplasmic dopamine levels, perhaps attributable to changes in vesicular monoamine transporter function, contribute to methamphetamine‐induced dopaminergic deficits. Hence, we examined whether striatal vesicular uptake is altered following methamphetamine treatment. Multiple administrations of methamphetamine rapidly (within 1 h) decreased vesicular dopamine uptake and dihydrotetrabenazine binding, an effect that (a) persisted at least 24 h, (b) was associated with dopamine and not serotonin neurons, and (c) was unrelated to residual drug introduced by the original methamphetamine treatment. These data suggest that methamphetamine rapidly decreases vesicular monoamine transporter function in dopaminergic neurons, a phenomenon that may be associated with the long‐term damage caused by this stimulant.
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Citations
Cites
Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones
GRAHAM, D. G. (1978) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13535-9 · Cited by 1,126
Cited by
New Insights into the Mechanism of Action of Amphetamines
Fleckenstein, A. E., Volz, T. J., Riddle, E. L., Gibb, J. W., & Hanson, G. R. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105140 · Cited by 731
Self-citationRole of Tumor Necrosis Factor-α in Methamphetamine-Induced Drug Dependence and Neurotoxicity
Nakajima, A., Yamada, K., Nagai, T., Uchiyama, T., Miyamoto, Y., Mamiya, T., He, J., Nitta, A., Mizuno, M., Tran, M. H., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4847-03.2004 · Cited by 176
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148
Vesicular monoamine transporter 2: Role as a novel target for drug development
Zheng, G., Dwoskin, L. P., & Crooks, P. A. (2006) · The AAPS Journal · doi:10.1208/aapsj080478 · Cited by 125
Riddle, E. L., Hanson, G. R., & Fleckenstein, A. E. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.044 · Cited by 49
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Metadata
- Authors
- Brown, J. M., Hanson, G. R., & Fleckenstein, A. E.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2000-05
- Volume
- 74
- Issue
- 5
- Pages
- 2221-2223
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1973845575
- Cited by
- 158
- References
- 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brown, J. M., Hanson, G. R., & Fleckenstein, A. E. (2000). Methamphetamine Rapidly Decreases Vesicular Dopamine Uptake. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2000.0742221.x
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