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Cited by 324Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Overexpression of dopamine D2 receptors reduces alcohol self‐administration

Thanos, Panayotis K., Volkow, Nora D., Freimuth, Paul, Umegaki, Hiroyuki, Ikari, Hiroyuki, Roth, George, Ingram, Donald K., Hitzemann, Robert·2001·Journal of Neurochemistry
DOI 10.1046/j.1471-4159.2001.00492.x
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Abstract

The mechanism(s) underlying predisposition to alcohol abuse are poorly understood but may involve brain dopamine system(s). Here we used an adenoviral vector to deliver the dopamine D2 receptor (DRD2) gene into the nucleus accumbens of rats, previously trained to self‐administer alcohol, and to assess if DRD2 levels regulated alcohol preference and intake. We show that increases in DRD2 (52%) were associated with marked reductions in alcohol preference (43%), and alcohol intake (64%) of ethanol preferring rats, which recovered as the DRD2, returned to baseline levels. In addition, this DRD2 overexpression similarly produced significant reductions in ethanol non‐preferring rats, in both alcohol preference (16%) and alcohol intake (75%). This is the first evidence that overexpression of DRD2 reduces alcohol intake and suggests that high levels of DRD2 may be protective against alcohol abuse.

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Crossref · 10.1046/j.1471-4159.2001.00492.x

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Show all 57 references

Research works printed but not linked: 6

  1. Crews F. T., 2000, Neurotoxicity of alcohol: excitotoxicity, oxidative stress, neurotrophic factors, apoptosis, and cell adhesion molecules, NIAAA Res. Monograph, 34, 189
  2. Le A. D., 1988, Biomedical and Social Aspects of Alcohol and Alcoholism, 423
  3. 10.1016/0922-4106(94)90044-2 · DOI
  4. 10.1111/j.1530-0277.2000.tb02014.x · DOI
  5. Weiss F., 2000, Neuroadaptive changes in neurotransmitter systems mediating ethanol‐induced behaviors, NIAAA Res. Monograph, 34, 261
  6. Williams G. D., 1987, Epidemiologic Bull. No. 15: Demographic trends, alcohol abuse and alcoholism, 1985–95, Alcohol Health Res. World, 11, 80

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Metadata

Authors
Thanos, P. K., Volkow, N. D., Freimuth, P., Umegaki, H., Ikari, H., Roth, G., Ingram, D. K., & Hitzemann, R.
Affiliations
  • Brookhaven National Laboratory (US)
  • Pediatrics and Genetics (US)
  • Nagoya University (JP)
  • National Institute on Aging (US)
  • Oregon Health & Science University (US)
Corresponding author
Thanos, Panayotis K.
ORCID
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2001-09
Volume
78
Issue
5
Pages
1094-1103
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1046/j.1471-4159.2001.00492.x
OpenAlex
W2141536473
Cited by
324
References
57
Citations by year
2026: 3 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 27 · 2019: 14 · 2018: 13 · 2017: 8 · 2016: 16 · 2015: 22 · 2014: 12 · 2013: 20 · 2012: 16
FWCI
6.04
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 110 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Energy
  • National Institute on Alcohol Abuse and Alcoholism (R01AA011034, AA 07574, AA11034, T32AA007574)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine D2 receptor, alcohol self-administration, alcohol preference, alcohol consumption, nucleus accumbens, dopaminergic system, adenoviral gene transfer
MeSH terms
Adenoviridae, Alcohol Drinking, Animals, Behavior, Animal, Brain Chemistry, Disease Models, Animal, Nucleus Accumbens, Self Administration, Genetic Therapy, Gene Expression, Rats, Sprague-Dawley, Receptors, Dopamine D2, Rats

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