Cited by 324Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

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Overexpression of dopamine D2 receptors reduces alcohol self‐administration

Thanos, Panayotis K., Volkow, Nora D., Freimuth, Paul, Umegaki, Hiroyuki, Ikari, Hiroyuki, Roth, George, Ingram, Donald K., Hitzemann, Robert·2001·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.2001.00492.x

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Abstract

The mechanism(s) underlying predisposition to alcohol abuse are poorly understood but may involve brain dopamine system(s). Here we used an adenoviral vector to deliver the dopamine D2 receptor (DRD2) gene into the nucleus accumbens of rats, previously trained to self‐administer alcohol, and to assess if DRD2 levels regulated alcohol preference and intake. We show that increases in DRD2 (52%) were associated with marked reductions in alcohol preference (43%), and alcohol intake (64%) of ethanol preferring rats, which recovered as the DRD2, returned to baseline levels. In addition, this DRD2 overexpression similarly produced significant reductions in ethanol non‐preferring rats, in both alcohol preference (16%) and alcohol intake (75%). This is the first evidence that overexpression of DRD2 reduces alcohol intake and suggests that high levels of DRD2 may be protective against alcohol abuse.

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Authors: Thanos, P. K., Volkow, N. D., Freimuth, P., Umegaki, H., Ikari, H., Roth, G., Ingram, D. K., & Hitzemann, R.
Affiliations: Brookhaven National Laboratory (US)
Pediatrics and Genetics (US)
Nagoya University (JP)
National Institute on Aging (US)
Oregon Health & Science University (US)
Corresponding author: Thanos, Panayotis K.
ORCID: Volkow, Nora D.
Freimuth, Paul
Umegaki, Hiroyuki
Ingram, Donald K.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2001-09
Volume: 78
Issue: 5
Pages: 1094-1103
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.2001.00492.x
OpenAlex: W2141536473
Cited by: 324
References: 57
Citations by year: 2026: 3 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 27 · 2019: 14 · 2018: 13 · 2017: 8 · 2016: 16 · 2015: 22 · 2014: 12 · 2013: 20 · 2012: 16
FWCI: 6.04
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 110 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Energy
National Institute on Alcohol Abuse and Alcoholism (R01AA011034, AA 07574, AA11034, T32AA007574)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine D2 receptor, alcohol self-administration, alcohol preference, alcohol consumption, nucleus accumbens, dopaminergic system, adenoviral gene transfer
MeSH terms: Adenoviridae, Alcohol Drinking, Animals, Behavior, Animal, Brain Chemistry, Disease Models, Animal, Nucleus Accumbens, Self Administration, Genetic Therapy, Gene Expression, Rats, Sprague-Dawley, Receptors, Dopamine D2, Rats

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Overexpression of dopamine D2 receptors reduces alcohol self‐administration

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