The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite
Abstract
Programmed cell death occurs after ischemic, excitotoxic, and traumatic brain injury (TBI). Recently, a caspase‐independent pathway involving intranuclear translocation of mitochondrial apoptosis‐inducing factor (AIF) has been reported in vitro; but whether this occurs after acute brain injury was unknown. To address this question adult rats were sacrificed at various times after TBI. Western blot analysis on subcellular protein fractions demonstrated intranuclear localization of AIF in ipsilateral cortex and hippocampus at 2–72 h. Immunocytochemical analysis showed AIF labeling in neuronal nuclei with DNA fragmentation in the ipsilateral cortex and hippocampus. Immunoelectronmicroscopy verified intranuclear localization of AIF in hippocampal neurons after TBI, primarily in regions of euchromatin. Large‐scale DNA fragmentation (∼50 kbp), a signature event in AIF‐mediated cell death, was detected in ipsilateral cortex and hippocampi by 6 h. Neuron‐enriched cultures exposed to peroxynitrite also demonstrated intranuclear AIF and large‐scale DNA fragmentation concurrent with impaired mitochondrial respiration and cell death, events that are inhibited by treatment with a peroxynitrite decomposition catalyst. Intranuclear localization of AIF and large‐scale DNA fragmentation occurs after TBI and in neurons under conditions of oxidative/nitrosative stress, providing the first evidence of this alternative mechanism by which programmed cell death may proceed in neurons after brain injury.
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Cites
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Cited by
Nitric Oxide and Peroxynitrite in Health and Disease
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Self-citationApoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
Yu, S.-W., Andrabi, S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606528103 · Cited by 718
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
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Role of AIF in caspase-dependent and caspase-independent cell death
Cregan, S. P., Dawson, V. L., & Slack, R. S. (2004) · Oncogene · doi:10.1038/sj.onc.1207517 · Cited by 517
Metadata
- Authors
- Zhang, X., Chen, J., Graham, S. H., Du, L., Kochanek, P. M., Draviam, R., Guo, F., Nathaniel, P. D., Szabó, C., Watkins, S. C., & Clark, R. S. B.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2002-06-25
- Volume
- 82
- Issue
- 1
- Pages
- 181-191
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2041207883
- Cited by
- 254
- References
- 46
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, X., Chen, J., Graham, S. H., Du, L., Kochanek, P. M., Draviam, R., Guo, F., Nathaniel, P. D., Szabó, C., Watkins, S. C., & Clark, R. S. B. (2002). Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.2002.00975.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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