Enhanced detection and retrograde axonal transport of PrPc in peripheral nerve
Abstract
Neuroinvasion of the CNS during orally acquired transmissible spongiform encephalopathies (TSEs) may involve the transport of the infectious agent from the periphery to the CNS via the peripheral nerves. If this occurs within axons, the mechanism of axonal transport may be fundamental to the process. In studies of peripheral nerve we observed that the cellular prion protein (PrPc) is highly resistant to detergent extraction. The implication of this is an underestimation of the abundance of PrPc in peripheral nerve. We have developed nerve extraction conditions that enhance the quantification of the protein in nerve 16-fold. Application of these conditions to evaluate the accumulation of PrPc distal to a cut nerve now reveals that PrPc is retrogradely transported from the axon ending. These results provide a potential cellular mechanism for TSE infectivity to gain entry to the CNS from the periphery.
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PrPC moves in anterograde and retrograde directions in nerves.
“Previous studies showed that PrPC moved in anterograde and retrograde directions in nerves”
From Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles (2011) · cites this paper as Moya et al., 2004
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The cellular prion protein (PrPC): Its physiological function and role in disease
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“In addition, PrPC is subject to anterograde and retrograde axonal transport [131,132], and PrPEGFP fusion proteins can be visualized in what appear to be axonally transported synaptic vesicles (Medrano and Harris, unpublished observations).”
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“been shown to be retrogradely transported from the axon ending along peripheral nerves [35], PrP could also be subjected”
BackgroundExpression of cellular prion protein (PrPc) in schizophrenia, bipolar disorder, and depression
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“Anterograde as well as retrograde transport mechanisms have been discussed for PrPC (Moya et al. 2004; Butowt et al. 2005).”
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“Modifications to extraction protocols for nerves and solid tissues were required (Moya et al., 2004), and up to 62.5 mg TE was analysed using an extended protocol and NaPTA.”
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“By using a test section accumulation paradigm, Ken Moya showed that at the whole nerve level, PrPC moves along sciatic nerve axons in anterograde and retrograde directions (Rodolfo et al. 1999; Moya et al. 2004).”
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“Retrograde transport of endogenous PrPc (from nerve terminal toward soma) has been examined less, however this direction of PrPc movement was recently described (Moya et al., 2004).”
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- Authors
- Moya, K. L., Hässig, R., Créminon, C., Laffont, I., & Di Giamberardino, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Corresponding author
- Moya, Kenneth L.
- ORCID
- Moya, Kenneth L.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2003-11-28
- Volume
- 88
- Issue
- 1
- Pages
- 155-160
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1538599226
- Cited by
- 58
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- cellular prion protein, retrograde axonal transport, peripheral nerves, prion disease, neuroinvasion, prion detection, axon terminals
- MeSH terms
- Animals, Axonal Transport, Cerebral Cortex, Cricetinae, Immunologic Techniques, Peripheral Nerves, Sciatic Nerve, Sodium Dodecyl Sulfate, Blotting, Western, Reproducibility of Results, PrPC Proteins
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