Cited by 237Telomeres, Telomerase, and SenescenceMitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

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Mitochondrial dysfunction leads to telomere attrition and genomic instability

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Liu, Lin, Trimarchi, James R., Smith, Peter J. S., Keefe, David L.·2002·Aging Cell

DOI 10.1046/j.1474-9728.2002.00004.x

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Abstract

Summary: Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence, apoptosis, aging and aging‐associated pathologies. Telomere shortening and genomic instability have also been associated with replicative senescence, aging and cancer. Here we show that mitochondrial dysfunction leads to telomere attrition, telomere loss, and chromosome fusion and breakage, accompanied by apoptosis. An antioxidant prevented telomere loss and genomic instability in cells with dysfunctional mitochondria, suggesting that reactive oxygen species are mediators linking mitochondrial dysfunction and genomic instability. Further, nuclear transfer protected genomes from telomere dysfunction and promoted cell survival by reconstitution with functional mitochondria. This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging‐associated pathologies.

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Mitochondria and Apoptosis
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,402
Protein Oxidation in Aging, Disease, and Oxidative Stress
Berlett, B. S., & Stadtman, E. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20313 · Cited by 3,379
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133
Mitochondrial control of cell death
Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060

Show all 49 references

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“…been shown that treating mouse embryos with chemicals able to induce mitochondrial dysfunction and ROS accumulation, led to telomere loss and chromosomal instability, which was prevented by a concomitant treatment with N-acetylcysteine, a compound that improves ROS scavenging (Liu et al., 2002).”
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Authors: Liu, L., Trimarchi, J. R., Smith, P. J. S., & Keefe, D. L.
Affiliations: Marine Biological Laboratory (US)
Corresponding author: Keefe, David L.
ORCID: Liu, Lin
Smith, Peter J. S.
Keefe, David L.
Venue: Aging Cell
Publisher: Wiley
Published: 2002-09-15
Volume: 1
Issue: 1
Pages: 40-46
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1046/j.1474-9728.2002.00004.x
OpenAlex: W2171912874
Cited by: 237
References: 49
Citations by year: 2026: 6 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 6 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 13
FWCI: 4.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (acceptedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: mitochondrial dysfunction, telomere shortening, telomere loss, genomic instability, chromosome fusion, chromosome breakage, apoptosis, oxidative stress, reactive oxygen species, replicative senescence, nuclear transfer, antioxidant defense, aging
MeSH terms: Animals, Antioxidants, Cell Division, Cell Nucleus, Female, Male, Mice, Inbred C3H, Mice, Inbred C57BL, Mitochondria, Zygote, Tissue Transplantation, Telomere, Cellular Senescence, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Chromosome Breakage, Mice, Nuclear Transfer Techniques

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Mitochondrial dysfunction leads to telomere attrition and genomic instability

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