Toward understanding genomic instability, mitochondrial dysfunction and aging

The Hallmarks of Aging

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Oxidants, oxidative stress and the biology of ageing

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Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

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Instability and decay of the primary structure of DNA

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Increased oxidative stress in obesity and its impact on metabolic syndrome

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Oxidative Stress, Glutamate, and Neurodegenerative Disorders

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Mitochondrial Fission, Fusion, and Stress

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

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hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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DNA damage, aging, and Cancer

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Self-consumption: the interplay of autophagy and apoptosis

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

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Causes and consequences of replication stress

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Sirtuins as regulators of metabolism and healthspan

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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

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Repair Pathway Choices and Consequences at the Double-Strand Break

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Ubiquitin is phosphorylated by PINK1 to activate parkin

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Aging, energy, and oxidative stress in neurodegenerative diseases

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Mitochondrial abnormalities in Alzheimer's disease

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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Nix is a selective autophagy receptor for mitochondrial clearance

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Mitochondrial Dynamics and Metabolic Regulation

Wai, T., & Langer, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.001 · Cited by 1,304 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

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SIRT1 and other sirtuins in metabolism

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

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DNA Repair, Genome Stability, and Aging

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

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Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

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Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

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SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

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Oxidative stress and metabolic syndrome

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

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G-quadruplex structures: in vivo evidence and function

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Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

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Nucleotide Excision Repair in EukaryotesPreprint

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Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

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SLP‐2 is required for stress‐induced mitochondrial hyperfusion

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Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

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On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1Preprint

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Ubiquitin-Dependent And Independent Signals In Selective Autophagy

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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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Bioenergetic role of mitochondrial fusion and fission

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PINK1 is degraded through the N-end rule pathway

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Role of Telomeres and Telomerase in Aging and Cancer

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Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

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PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites

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NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.004 · Cited by 575 · see citing works

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

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Consequences of oxidative stress in age-related macular degeneration

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The dynamic regulation of NAD metabolism in mitochondria

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Chaudhuri, A. R., Hashimoto, Y., Herrador, R., Neelsen, K. J., Fachinetti, D., Bermejo, R., Cocito, A., Costanzo, V., & Lopes, M. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2258 · Cited by 499 · see citing works

Replication fork reversal in eukaryotes: from dead end to dynamic response

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The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

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NAD ⁺ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718819115 · Cited by 472 · see citing works

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

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Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

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Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

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SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

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Investigating mitochondrial redox state using NADH and NADPH autofluorescence

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Nuclear DNA damage signalling to mitochondria in ageing

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The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

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Mitochondrial dysfunction in ataxia-telangiectasia

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Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics

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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in Cockayne syndrome

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PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

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NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

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Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations

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SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

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Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions

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