Cited by 257Skin Protection and Agingmelanin and skin pigmentationDNA Repair Mechanisms

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Supranuclear Melanin Caps Reduce Ultraviolet Induced DNA Photoproducts in Human Epidermis

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Kobayashi, Nobuhiko, Nakagawa, Akemi, Muramatsu, Tsutomu, Yamashina, Yukio, Shirai, Toshihiko, Hashimoto, Mitsumasa W., Ishigaki, Yasuhito, Ohnishi, Takeo, Mori, Toshio·1998·Journal of Investigative Dermatology

DOI 10.1046/j.1523-1747.1998.00178.x

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Abstract

Melanin can form supranuclear caps in human epidermis, suggesting that intracellular melanin reduces ultraviolet transmission to underlying cell nuclei and inhibits the formation of ultraviolet induced DNA photoproducts. The purpose of this study was to determine the photoprotective effect of epidermal melanin. We irradiated normal human skin explants with ultraviolet B and determined the formation of cyclobutane pyrimidine dimers and (6-4)photoproducts in individual epidermal cells by indirect immunofluorescence and by laser cytometry using monoclonal antibodies specific for cyclobutane dimers or for (6-4)photoproducts. We found that epidermal cells with supranuclear melanin caps had significantly less DNA photoproducts (both types) than epidermal cells without supranuclear melanin caps. Moreover, the protection factor against both types of photolesions correlated with melanin concentration in epidermal cells. These results indicate that melanin reduces ultraviolet induced DNA photoproducts in human epidermis in a concentration dependent manner.

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Authors: Kobayashi, N., Nakagawa, A., Muramatsu, T., Yamashina, Y., Shirai, T., Hashimoto, M. W., Ishigaki, Y., Ohnishi, T., & Mori, T.
Affiliations: Nara Medical University (JP)
Kyoto University (JP)
Kanazawa University (JP)
Corresponding author: Mori, Toshio
ORCID: Kobayashi, Nobuhiko
Ishigaki, Yasuhito
Mori, Toshio
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 1998-05
Volume: 110
Issue: 5
Pages: 806-810
ISSN: 0022-202X (ISSN-L)
DOI: 10.1046/j.1523-1747.1998.00178.x
OpenAlex: W1979276428
Cited by: 257
References: 34
Citations by year: 2026: 6 · 2025: 18 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 11 · 2017: 11 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 9
FWCI: 11.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6452 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: Japanese Dermatological Association
Ministry of Education, Culture, Sports, Science and Technology
Cosmetology Research Foundation
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: melanin, UV-B radiation, DNA photoproducts, cyclobutane pyrimidine dimers, 6-4 photoproducts, photoprotection, human epidermis, skin explants, melanin content
MeSH terms: Aged, DNA, Epidermis, Humans, Male, Melanins, Pyrimidine Dimers, Reference Values, Skin, Ultraviolet Rays

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Supranuclear Melanin Caps Reduce Ultraviolet Induced DNA Photoproducts in Human Epidermis

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