Hair Follicle Stem Cells
Open accessAbstract
The workshop on Hair Follicle Stem Cells brought together investigators who have used a variety of approaches to try to understand the biology of follicular epithelial stem cells, and the role that these cells play in regulating the hair cycle. One of the main concepts to emerge from this workshop is that follicular epithelial stem cells are multipotent, capable of giving rise not only to all the cell types of the hair, but also to the epidermis and the sebaceous gland. Furthermore, such multipotent stem cells may represent the ultimate epidermal stem cell. Another example of epithelial stem cell and transit amplifying cell plasticity, was the demonstration that adult corneal epithelium, under the influence of embryonic skin dermis could form an epidermis as well as hair follicles. With regards to the location of follicular epithelial stem cells, immunohistochemical and ultrastructural data was presented, indicating that cells with stem cell attributes were localized to the prominent bulge region of developing human fetal hair follicles. Finally, a new notion was put forth concerning the roles that the bulge-located stem cells and the hair germ cells played with respect to the hair cycle.
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The skin thickness, from the epidermis to subcutaneous tissue, changes with the hair cycle, being the thickest in anagen and thinnest in telogen.
“The skin thickness, from the epidermis to subcutaneous tissue, also changes with the hair cycle, being the thickest in anagen and thinnest in telogen (Fig. 6)9, 31.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [31]
Hair follicles are formed by differentiation of the stem cells in the follicular bulb, called the bulge, where the arrector pili muscle joins.
“Hair follicles are formed by differentiation of the stem cells in the follicular bulb, called the bulge, where the arrector pili muscle joins1, 31.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [31]
Slow-cycling HF stem cells reside in a bulge region of the outer root sheath located proximal to the SG.
“It has been reported that slow-cycling HF stem cells reside in a bulge region of the outer root sheath located proximal to the SG (Cotsarelis et al., 1990; Lavker et al., 2003).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Lavker et al., 2003
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- Authors
- Lavker, R. M., Sun, T.-T., Oshima, H., Barrandon, Y., Akiyama, M., Ferraris, C., Chevalier, G., Favier, B., Jahoda, C. A. B., Dhouailly, D., Panteleyev, A. A., & Christiano, A. M.
- Affiliations
- Northwestern University (US)
- New York University (US)
- St. Marianna University School of Medicine (JP)
- École Normale Supérieure - PSL (FR)
- Hokkaido University (JP)
- Centre National de la Recherche Scientifique (FR)
- Durham University (GB)
- Columbia University (US)
- Corresponding author
- Lavker, Robert M.
- ORCID
- Venue
- Journal of Investigative Dermatology Symposium Proceedings
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 8
- Issue
- 1
- Pages
- 28-38
- ISSN
- 1087-0024 (ISSN-L)
- OpenAlex
- W2000844878
- Cited by
- 169
- References
- 70
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 9 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 10
- FWCI
- 15.86
- Type
- conference paper
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology Symposium Proceedings (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Institutes of Health (5r03ar047403-03)
- U.S. Public Health Service (P30-44534, R01 47338)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R03-AR47403, K01AR002204, KO1-AR02204)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- hair follicle stem cells, hair cycle, multipotency, epidermal stem cells, sebaceous glands, corneal epithelium, stem cell plasticity, transit amplifying cells, bulge, hair germ
- MeSH terms
- Animals, Embryo, Mammalian, Epidermis, Humans, Models, Biological, Skin, Stem Cells, Hair Follicle, Epithelium, Corneal
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