Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Open accessAbstract
The location of follicular and epidermal stem cells in mammalian skin is a crucial issue in cutaneous biology. We demonstrate that hair follicular stem cells, located in the bulge region, can give rise to several cell types of the hair follicle as well as upper follicular cells. Moreover, we devised a double-label technique to show that upper follicular keratinocytes emigrate into the epidermis in normal newborn mouse skin, and in adult mouse skin in response to a penetrating wound. These findings indicate that the hair follicle represents a major repository of keratinocyte stem cells in mouse skin, and that follicular bulge stem cells are potentially bipotent as they can give rise to not only the hair follicle, but also the epidermis.
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Initiation of a new anagen cycle depends upon activation of a small number of quiescent stem cells that reside in the bulge.
“Initiation of a new anagen cycle depends upon activation of a small number of quiescent stem cells that reside in the bulge, a niche at the follicle base15–19.”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [16]
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- Authors
- Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M.
- Affiliations
- University of Pennsylvania (US)
- New York University (US)
- Corresponding author
- Sun, Tung-Tien
- Lavker, Robert M
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 102
- Issue
- 4
- Pages
- 451-461
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2104058491
- Cited by
- 1,070
- References
- 73
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 16 · 2023: 16 · 2022: 20 · 2021: 16 · 2020: 32 · 2019: 35 · 2018: 20 · 2017: 23 · 2016: 30 · 2015: 41 · 2014: 34 · 2013: 49 · 2012: 49
- FWCI
- 74.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ar042998-04)
- National Eye Institute (EY 06769)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 39753, R01DK039753)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR42998)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- hair follicle stem cells, epidermis, epidermal stem cells, wound healing, skin regeneration, mouse skin
- MeSH terms
- Animals, Epidermis, Mice, Inbred C57BL, Stem Cells, Keratinocytes, Hair Follicle, Mice
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