Cited by 541Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

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Inflammatory Events Are Involved in Acne Lesion Initiation

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Jeremy, Anthony H.T., Holland, Diana B., Roberts, Susan G., Thomson, Kathryn F., Cunliffe, William J.·2003·Journal of Investigative Dermatology

DOI 10.1046/j.1523-1747.2003.12321.x

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Abstract

The earliest subclinical acne "lesion" is a microcomedone, of which hyperproliferation of the follicular epithelium is a characteristic feature. Inflammatory cells have been observed at the periphery of these "lesions". This study investigated whether inflammatory events occur pre or post hyperproliferative changes. Cellular, vascular, and proliferative markers were examined by immunohistochemical techniques on biopsies of clinically normal follicles from uninvolved skin and early inflamed lesions from acne patients. Control follicles were obtained from non-acne subjects. Follicles from uninvolved skin exhibited no microcomedonal features. Proliferation in the epithelium was comparable to controls and was significantly lower than in inflamed lesions. Numbers of CD3+, CD4+ T cells were elevated in the perifollicular and papillary dermis although levels were not equivalent to those in papules. The number of macrophages was also greatly increased and similar to those in papules. There were no changes in blood vessel numbers or vascular intercellular adhesion molecule 1 expression but E-selectin expression was increased to levels found in papules and vascular adhesion molecule 1 levels were upregulated. Levels of the pro-inflammatory cytokine interleukin-1 were also upregulated perifollicularly. Moreover, aberrant integrin expression was demonstrated in the epidermis around these uninvolved follicles and inflamed lesions whereas the basement membrane was still intact. These results provide novel evidence for vascular endothelial cell activation and involvement of inflammatory responses in the very earliest stages of acne lesion development.

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Exploring potential biomarkers for acne based on WGCNA and machine learning algorithms (Preprint)Preprint
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Authors: Jeremy, A. H. T., Holland, D. B., Roberts, S. G., Thomson, K. F., & Cunliffe, W. J.
Affiliations: Leeds General Infirmary (GB)
Corresponding author: Holland, Diana B.
ORCID: Cunliffe, William J.
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2003-07
Volume: 121
Issue: 1
Pages: 20-27
ISSN: 0022-202X (ISSN-L)
DOI: 10.1046/j.1523-1747.2003.12321.x
OpenAlex: W2062768474
Cited by: 541
References: 34
Citations by year: 2026: 13 · 2025: 30 · 2024: 52 · 2023: 28 · 2022: 20 · 2021: 28 · 2020: 26 · 2019: 32 · 2018: 29 · 2017: 24 · 2016: 23 · 2015: 19 · 2014: 35 · 2013: 27 · 2012: 17
FWCI: 16.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4537 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: acne, microcomedones, inflammation, T cells, macrophages, endothelial activation, E-selectin, VCAM-1, interleukin-1, integrins, basement membrane, follicular epithelium, vascular adhesion molecules
MeSH terms: CD68 Molecule, Acne Vulgaris, Adolescent, Adult, Blood Vessels, Cell Differentiation, Cell Division, HLA-DR Antigens, Humans, Immunohistochemistry, Immunologic Memory, Interleukin-1, Laminin, Langerhans Cells, Macrophages, Neutrophils, Antigens, Differentiation, Myelomonocytic, Biomarkers, CD4-Positive T-Lymphocytes, Keratinocytes, Antigens, CD, CD3 Complex, Receptors, Interleukin-1, Leukocyte Common Antigens, CD8-Positive T-Lymphocytes, Hair Follicle, Antigens, CD1, Collagen Type IV, Integrin alpha6, Receptors, Interleukin-1 Type II

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Inflammatory Events Are Involved in Acne Lesion Initiation

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