The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Renal catabolism of advanced glycation end products: The fate of pentosidine
Open accessAbstract
Advanced glycation end products (AGEs) generated through the Maillard reaction significantly alter protein characteristics. Their accumulation has been incriminated in tissue injury associated with aging, diabetes, and renal failure. However, little is known about their clearance from the body. The present study delineates the catabolic pathway of a well-defined AGE product, pentosidine. Synthesized pentosidine given intravenously in rats with normal renal function was rapidly eliminated from the circulation through glomerular filtration, but was undetectable in the urine by chemical analysis. Immunohistochemistry with anti-pentosidine antibody disclosed that pentosidine accumulated transiently in the proximal renal tubule one hour after its administration, but had disappeared from the kidney at 24 hours. After an intravenous load of radiolabeled pentosidine, radioactivity peaked in the kidney at one hour and subsequently decreased, whereas it rose progressively in the urine. Over 80% of the radioactivity was recovered in the 72-hour collected urine. However, only 20% of urine radioactivity was associated with intact pentosidine chemically or immunochemically. In gentamicin-treated rats with tubular dysfunction, up to 30% of the pentosidine load was recovered as intact pentosidine in the urine. The present study suggests that free pentosidine (and possibly other AGEs) is filtered by renal glomeruli, reabsorbed in the proximal tubule where it is degraded or modified, and eventually excreted in the urine. Kidney thus plays a key role in pentosidine disposal.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The increase in abdominal fat mass is associated with a chronic elevation of the circulating concentrations of inflammatory mediators including several acute-phase inflammatory proteins such as CRP (46,47) , proand anti-inflammatory cytokines, adhesion molecules and pro-thrombotic molecules (22,47 -49) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [48]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,545
Yan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305
Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix
Sell, D. R., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88225-8 · Cited by 1,082
Advanced Glycosylation End Products in Patients with Diabetic Nephropathy
Makita, Z., Radoff, S., Rayfield, E. J., Yang, Z. H., Skolnik, E. Y., DELANEY, V. B., Friedman, E. A., Cerami, A., & Vlassara, H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109193251202 · Cited by 922
Ahmed, M. U., Thorpe, S. R., & Baynes, J. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89188-3 · Cited by 864
Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
Dyer, D. G., Dunn, J. A., Thorpe, S. R., Bailie, K., Lyons, T. J., McCance, D. R., & Baynes, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116481 · Cited by 770
Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling
Vlassara, H., Brownlee, M., Manogue, K. R., Dinarello, C. A., & Pasagian, A. (1988) · Science · doi:10.1126/science.3259727 · Cited by 597
Wells‐Knecht, K. J., Zyzak, D. V., Litchfield, J., Thorpe, S. R., & Baynes, J. (1995) · Biochemistry · doi:10.1021/bi00011a027 · Cited by 594
Cited by
Sorted by citations
Items 201–227 of 227
Diabetic glomerulopathy-natural history, intervention and prediction of complications
Perrin, N. (2008) · Figshare
MELLITUSBAN ÉS VESEBETEGSÉGBEN
Wittmann, I. (2013)
Assessing and Modifying Bone Quality in Chronic Kidney Disease
Newman, C. L. (2015) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2104
"Diabetic retinopathy; from glycation to clinical aspects"
Fosmark, D. S. (2008) · NORA - Norwegian Open Research Archives
Kamada, Y., Masuda, T., Kotani, K., Tanaka, S., Nakamura, T., Hamazaki, N., Ito, Y., Moriguchi, I., Kobayashi, N., Okubo, M., et al. (2017) · Renal Replacement Therapy · doi:10.1186/s41100-017-0135-6
Fernando, D. H., Forbes, J. M., Angus, P., & Herath, C. B. (2020) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pamb.1.2020.25
The Interaction of Nutrition with Nuclear Receptors in Obesity and Diabetes
Tovar‐Palacio, C., Noriega, L. G., Torre-Villalvazo, I., Díaz‐Villaseñor, A., & Palacios‐González, B. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160608-00094
Miyata, T., & Kurokawa, K. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391934-2.00007-2
Brown, C. D., Zhao, Z., Thomas, L. L., deGroof, R., & Friedman, E. A. (2002) · Springer eBooks · doi:10.1007/978-94-017-1848-6_12
HEART's Original [臨床研究] 終末糖化産物のーつであるペントシジンは心不全の危険因子である
小山, 容., 竹石, 恭., 有本, 貴., 新関, 武., 宍戸, 哲., 高橋, 大., 野崎, 直., 廣野, 摂., 角田, 裕., 二藤部, 丈., et al. (2007) · 心臓 · doi:10.11281/shinzo1969.39.1_22
Paschalis, E. P. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725272032.793563266
Gao, D. Y., Kraus, M. A., Ronco, C., & Clark, W. R. (2004) · Springer eBooks · doi:10.1007/978-94-007-1031-3_2
Modulação in vitro da barreira epitelial tubular renal mediada pelas junções de oclusão
Mongelli-Sabino, B. M. (2015) · doi:10.47749/t/unicamp.2015.955760
任, 瑶. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.13112464
Tawfik, M. A., El-Sharawy, M. S. T., & Barseem, N. F. (2023) · Menoufia Medical Journal · doi:10.59204/2314-6788.1038
Untargeted Metabolite Profiling Reveals Acute Toxicity of Pentosidine on Adipose Tissue of Rats
Hu, C., Shao, Z., Wu, W., & Wang, J. (2024) · Metabolites · doi:10.3390/metabo14100539
Pentosidine and Bone Properties in Autosomal Dominant Polycystic Kidney Disease
Jankowska, M., Qureshi, A. R., Haarhaus, M. L., Magnusson, P., Dębska-Ślizień, A. M., Barany, P. F., Heimbürger, O., Stenvinkel, P., & Lindholm, B. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14217577
Recherche de biomarqueurs précoces de diagnostic de la néphropathie diabétique
Ameur, R. B. (2011) · theses.fr (ABES) · doi:10.70675/14f1b3fdzcf71z49d9z8fa5z0fb3bd127d7e
Ito, K., Takahashi, K., Tada, K., Maeda, T., Shinohara, Y., Inoue, Y., Satoh, A., Abe, M., Yasuno, T., Arima, H., et al. (2026) · BMC Nephrology · doi:10.1186/s12882-026-05022-9
Sobczyńska, J., Federowicz, J., Galińska, Z., Ziomek, M., Stach, W., Bronowicka-Szydełko, A., & Madziarska, K. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12545-9
Rethinking bone quality after FDA qualification of total hip BMD as a surrogate endpoint
Kawaguchi, H. (2026) · Bone Reports · doi:10.1016/j.bonr.2026.101968
Gutierres, V. O. (2011) · Americanae (AECID Library)
Metadata
- Authors
- Miyata, T., Ueda, Y., Horie, K., Nangaku, M., Tanaka, S., de Strihou, C. V. Y., & Kurokawa, K.
- Affiliations
- Tokai University (JP)
- Corresponding author
- Miyata, Toshio
- ORCID
- Nangaku, Masaomi
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 53
- Issue
- 2
- Pages
- 416-422
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1998110176
- Cited by
- 227
- References
- 26
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 10 · 2018: 4 · 2017: 12 · 2016: 1 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 8
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (96L00303)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- advanced glycation end products, pentosidine, Maillard reaction, glomerular filtration, proximal tubule, tubular reabsorption, urinary excretion, renal clearance, protein glycation
- MeSH terms
- Animals, Anti-Bacterial Agents, Arginine, Chromatography, High Pressure Liquid, Gentamicins, Kidney Diseases, Kidney Glomerulus, Kidney Tubules, Proximal, Lysine, Protein Synthesis Inhibitors, Glycation End Products, Advanced, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
