Cited by 227Advanced Glycation End Products researchChronic Kidney Disease and DiabetesDialysis and Renal Disease Management

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Renal catabolism of advanced glycation end products: The fate of pentosidine

Open access

Miyata, Toshio, Ueda, Yasuhiko, Horie, Katsunori, Nangaku, Masaomi, Tanaka, Shuichi, de Strihou, Charles van Ypersele, Kurokawa, Kiyoshi·1998·Kidney International

DOI 10.1046/j.1523-1755.1998.00756.x

Open this paper in CoChat — free account Open PDF

Abstract

Advanced glycation end products (AGEs) generated through the Maillard reaction significantly alter protein characteristics. Their accumulation has been incriminated in tissue injury associated with aging, diabetes, and renal failure. However, little is known about their clearance from the body. The present study delineates the catabolic pathway of a well-defined AGE product, pentosidine. Synthesized pentosidine given intravenously in rats with normal renal function was rapidly eliminated from the circulation through glomerular filtration, but was undetectable in the urine by chemical analysis. Immunohistochemistry with anti-pentosidine antibody disclosed that pentosidine accumulated transiently in the proximal renal tubule one hour after its administration, but had disappeared from the kidney at 24 hours. After an intravenous load of radiolabeled pentosidine, radioactivity peaked in the kidney at one hour and subsequently decreased, whereas it rose progressively in the urine. Over 80% of the radioactivity was recovered in the 72-hour collected urine. However, only 20% of urine radioactivity was associated with intact pentosidine chemically or immunochemically. In gentamicin-treated rats with tubular dysfunction, up to 30% of the pentosidine load was recovered as intact pentosidine in the urine. The present study suggests that free pentosidine (and possibly other AGEs) is filtered by renal glomeruli, reabsorbed in the proximal tubule where it is degraded or modified, and eventually excreted in the urine. Kidney thus plays a key role in pentosidine disposal.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.1523-1755.1998.00756.x

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,545
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
Yan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305
Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix
Sell, D. R., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88225-8 · Cited by 1,082
Advanced Glycosylation End Products in Patients with Diabetic Nephropathy
Makita, Z., Radoff, S., Rayfield, E. J., Yang, Z. H., Skolnik, E. Y., DELANEY, V. B., Friedman, E. A., Cerami, A., & Vlassara, H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109193251202 · Cited by 922
Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.
Ahmed, M. U., Thorpe, S. R., & Baynes, J. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89188-3 · Cited by 864
Accumulation of Maillard reaction products in skin collagen in diabetes and aging.
Dyer, D. G., Dunn, J. A., Thorpe, S. R., Bailie, K., Lyons, T. J., McCance, D. R., & Baynes, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116481 · Cited by 770
Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling
Vlassara, H., Brownlee, M., Manogue, K. R., Dinarello, C. A., & Pasagian, A. (1988) · Science · doi:10.1126/science.3259727 · Cited by 597
Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose
Wells‐Knecht, K. J., Zyzak, D. V., Litchfield, J., Thorpe, S. R., & Baynes, J. (1995) · Biochemistry · doi:10.1021/bi00011a027 · Cited by 594

Show all 26 references

Sorted by citations

Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
Goh, S.-Y., & Cooper, M. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1817 · Cited by 987
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?
Gilbert, R. E., & Cooper, M. E. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00721.x · Cited by 638
The Microinflammatory State in Uremia
Kaysen, G. A. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1271549 · Cited by 471
Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.
Horie, K., Miyata, T., Maeda, K., Miyata, S., Sugiyama, S., Sakai, H., van Ypersole de Strihou, C., Monnier, V. M., Witztum, J. L., & Kurokawa, K. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119853 · Cited by 433
A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease
Zhang, Q., Ames, J. M., Smith, R. D., Baynes, J. W., & Metz, T. O. (2009) · Journal of Proteome Research · doi:10.1021/pr800858h · Cited by 421
Advanced Glycation end Products, Oxidative Stress and Diabetic Nephropathy
Yamagishi, S., & Matsui, T. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.2.11148 · Cited by 399
Advanced glycation end products and the kidney
Bohlender, J. M., Franke, S., Stein, G., & Wolf, G. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00398.2004 · Cited by 389
AGE, RAGE, and ROS in Diabetic Nephropathy
Tan, A. L. Y., Forbes, J. M., & Cooper, M. E. (2007) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2007.01.006 · Cited by 371
Role of advanced glycation end products in cardiovascular disease
Hegab, Z. (2012) · World Journal of Cardiology · doi:10.4330/wjc.v4.i4.90 · Cited by 361
The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases
Shen, C., Lu, C., Wu, C.-H., Li, K., Kuo, Y., Hsieh, S., & Yu, C. (2020) · Molecules · doi:10.3390/molecules25235591 · Cited by 316
Advanced glycation end products: A nephrologist's perspective
Raj, D. S., Choudhury, D., Welbourne, T., & Levi, M. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70189-2 · Cited by 288
Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases
Reddy, V. P., & Beyaz, A. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.05.016 · Cited by 269
Advanced glycation End-products (AGEs): an emerging concern for processed food industries
Sharma, C., Kaur, A., Thind, S. S., Singh, B., & Raina, S. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-1851-y · Cited by 254
Immunohistochemical Evidence for an Increased Oxidative Stress and Carbonyl Modification of Proteins in Diabetic Glomerular Lesions
SUZUKI, D., Miyata, T., Saotome, N., Horie, K., Inagi, R., Yasuda, Y., Uchida, K., Izuhara, Y., Yagame, M., Sakai, H., et al. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v104822 · Cited by 255
Uremic Toxicity of Advanced Glycation End Products in CKD
Stinghen, A. E. M., Massy, Z. A., Vlassara, H., Striker, G. E., & Boullier, A. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101047 · Cited by 243
Treatment of Diabetic Kidney Disease: Current and Future
Yamazaki, T., Mimura, I., Tanaka, T., & Nangaku, M. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0217 · Cited by 246
Importance of measuring products of non-enzymatic glycation of proteins
Lapolla, A., Traldi, P., & Fedele, D. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.09.007 · Cited by 236
Advanced glycation end‐products and the kidney
Busch, M., Franke, S., Rüster, C., & Wolf, G. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02317.x · Cited by 228
Dietary advanced glycation end‐products: Perspectives linking food processing with health implications
Zhang, Q., Wang, Y., & Fu, L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12593 · Cited by 239
Unlocking the biology of RAGE in diabetic microvascular complications
Manigrasso, M. B., Juranek, J., Ramasamy, R., & Schmidt, A. M. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.08.002 · Cited by 209
Advanced glycation end products and mortality in hemodialysis patients
Schwedler, S. B., Metzger, T., Schinzel, R., & Wanner, C. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00423.x · Cited by 195
Diabetic neuropathy - a continuing enigma
Sugimoto, K., Murakawa, Y., & Sima, A. A. F. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(200011/12)16:6 · Cited by 188
Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product
Miyata, T., Ueda, Y., Yamada, Y., Izuhara, Y., Wada, T., Jadoul, M. Y., Saitō, A., Kurokawa, K., & de Strihou, C. V. Y. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v9122349 · Cited by 188
Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products
Fernando, D. H., Forbes, J. M., Angus, P. W., & Herath, C. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205037 · Cited by 184
The Mechanism of Hyperglycemia-Induced Renal Cell Injury in Diabetic Nephropathy Disease: An Update
Wu, T., Ding, L., Andoh, V., Zhang, J., & Chen, L. (2023) · Life · doi:10.3390/life13020539 · Cited by 208
Diabetic Nephropathy: Where Hemodynamics Meets Metabolism
Forbes, J. M., Fukami, K., & Cooper, M. E. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-949721 · Cited by 185
Studies on Absorption and Elimination of Dietary Maillard Reaction Products
FÖRSTER, A., KÜHNE, Y., & HENLE, T. O. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.054 · Cited by 180
Dietary Advanced Glycosylation End-Products (dAGEs) and Melanoidins Formed through the Maillard Reaction: Physiological Consequences of their Intake
Delgado‐Andrade, C., & Fogliano, V. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012441 · Cited by 177
Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging
Vlassara, H., Torreggiani, M., Post, J. B., Zheng, F., Uribarri, J., & Striker, G. E. (2009) · Kidney International · doi:10.1038/ki.2009.401 · Cited by 161
Activation of tubular epithelial cells in diabetic nephropathy.
Morcos, M., Sayed, A., Bierhaus, A., Yard, B., Waldherr, R., Merz, W., Kloeting, I., Schleicher, E., Mentz, S., el Baki, R. F. A., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3532 · Cited by 180
New insights into the metabolic and molecular basis for diabetic neuropathy
Sima, A. A. F. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3084-x · Cited by 155
Mechanisms for the formation of glycoxidation products in end-stage renal disease
Weiss, M. F., Erhard, P., Kader-Attia, F. A., Wu, Y. C., DeOreo, P. B., Araki, A., Glomb, M. A., & Monnier, V. M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00117.x · Cited by 155
Autoxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?
Miyata, T., Fu, M.-X., Kurokawa, K., de Strihou, C. V. Y., Thorpe, S. R., & Baynes, J. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00093.x · Cited by 151
Urinary biomarkers involved in type 2 diabetes: a review
Matheson, A., Willcox, M. D. P., Flanagan, J., & Walsh, B. J. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1068 · Cited by 150
RAGE signaling regulates the progression of diabetic complications
Taguchi, K., & Fukami, K. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1128872 · Cited by 144
Increased oxidative stress in mouse kidneys with unilateral ureteral obstruction
Kawada, N., Moriyama, T., Ando, A., Fukunaga, M., Miyata, T., Kurokawa, K., Imai, E., & Hori, M. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00612.x · Cited by 140
Plasma Pentosidine Is Associated with Inflammation and Malnutrition in End-Stage Renal Disease Patients Starting on Dialysis Therapy
Suliman, M. E., Heimbürger, O., Barany, P. F., Anderstam, B., Pecoits‐Filho, R., Ayala, E. R., Qureshi, A. R., Fehrman‐Ekholm, I., Lindholm, B., & Stenvinkel, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000067413.32377.cf · Cited by 138
Health effects of dietary Maillard reaction products: the results of ICARE and other studies
Tessier, F. J., & Birlouez‐Aragon, I. (2010) · Amino Acids · doi:10.1007/s00726-010-0776-z · Cited by 136
High Serum Level of Pentosidine, an Advanced Glycation End Product (AGE), is a Risk Factor of Patients with Heart Failure
Koyama, Y., Takeishi, Y., Arimoto, T., Niizeki, T., Shishido, T., Takahashi, H., Nozaki, N., Hirono, O., Tsunoda, Y., Nitobe, J., et al. (2007) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.11.009 · Cited by 133
Regional Arterial Stiffness in Patients with Type 2 Diabetes and Chronic Kidney Disease
Kimoto, E., Shoji, T., Shinohara, K., Hatsuda, S., Mori, K., Fukumoto, S., Koyama, H., Emoto, M., Okuno, Y., & Nishizawà, Y. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005101038 · Cited by 130
Advanced glycation and lipidoxidation of the peritoneal membrane: Respective roles of serum and peritoneal fluid reactive carbonyl compounds
Miyata, T., Horie, K., Ueda, Y., Fujita, Y., Izuhara, Y., Hirano, H., Uchida, K., Saitō, A., de Strihou, C. V. Y., & Kurokawa, K. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00182.x · Cited by 128
Glycation as the glucose link to diabetic complications.
Gugliucci, A. (2000) · PubMed · Cited by 127
Advanced glycated end-products (AGE) during haemodialysis treatment: discrepant results with different methodologies reflecting the heterogeneity of AGE compounds
Henle, T., Deppisch, R. M., Beck, W., Hergesell, O., Hänsch, G. M., & Ritz, E. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.8.1968 · Cited by 125
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy
Tan, A. L. Y., Sourris, K. C., Harcourt, B. E., Thallas‐Bonke, V., Penfold, S. A., Andrikopoulos, S., Thomas, M. C., O’Brien, R. C., Bierhaus, A., Cooper, M. E., et al. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00591.2009 · Cited by 125
Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules
Takahashi, A., Takabatake, Y., Kimura, T., Maejima, I., Namba, T., Yamamoto, T., Matsuda, J., Minami, S., Kaimori, J.-Y., Matsui, I., et al. (2017) · Diabetes · doi:10.2337/db16-0397 · Cited by 122
Inflammation and nutrition in renal insufficiency
Kalantar‐Zadeh, K., Stenvinkel, P., Pillon, L., & Kopple, J. D. (2003) · Advances in Renal Replacement Therapy · doi:10.1053/j.arrt.2003.08.008 · Cited by 120
Apoptosis in ischemic renal injury: Roles of GTP depletion and p53
Dagher, P. C. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.761_7.x · Cited by 118
Low-GDP fluid (Gambrosol trio(R)) attenuates decline of residual renal function in PD patients: a prospective randomized study
Haag–Weber, M., Kramer, R., Haake, R., Islam, M. S., Prischl, F. C., Haug, U., Nabut, J. L., Deppisch, R. M., & on behalf of the DIUREST Study Group (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq087 · Cited by 111
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?
Fotheringham, A. K., Gallo, L. A., Borg, D. J., & Forbes, J. M. (2022) · Nutrients · doi:10.3390/nu14132675 · Cited by 116
Comparison of Free and Bound Advanced Glycation End Products in Food: A Review on the Possible Influence on Human Health
Zhao, D., Sheng, B., Wu, Y., Li, H., Xu, D., Nian, Y., Mao, S., Li, C., Xu, X., & Zhou, G. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05891 · Cited by 107
Increased accumulation of the glycoxidation product Nε-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody
Schalkwijk, C. G., Baidoshvili, A., Stehouwer, C. D. A., van Hinsbergh, V. W. M., & Niessen, H. W. M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2003.07.002 · Cited by 107
Evidence against dietary advanced glycation endproducts being a risk to human health
Ames, J. M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600304 · Cited by 104
Nϵ-(carboxymethyl)lysine levels in patients with type 2 diabetes: Role of renal function
Wagner, Z., Wittmann, I., Mazák, I., Schinzel, R., Heidland, A., Kientsch-Engel, R., & Nagy, J. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.27695 · Cited by 104
Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis
Pavelká, K., Forejtová, Š., Olejarová, M., Gatterová, J., Šenolt, L., Špaček, P., BRAUN, M. A., Hulejová, M., Stovícková, J., & Pavelková, A. (2004) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2004.01.001 · Cited by 103
Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-Based Therapeutics
Kokil, G. R., Veedu, R. N., Ramm, G. A., Prins, J. B., & Parekh, H. S. (2015) · Chemical Reviews · doi:10.1021/cr5002832 · Cited by 100
Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat
Alderson, N. L., Chachich, M. E., Frizzell, N., Canning, P., Metz, T., Januszewski, A. S., Youssef, N., Stitt, A. W., Baynes, J., & Thorpe, S. R. (2004) · Diabetologia · doi:10.1007/s00125-004-1474-8 · Cited by 97
The fate of dietary advanced glycation end products in the body: from oral intake to excretion
Liang, Z., Chen, X., Li, L., Li, B., & Yang, Z. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1693958 · Cited by 97
Determinants of Progression of Aortic Stiffness in Hemodialysis Patients
Utescu, M. S., Couture, V., Mac‐Way, F., Serres, S. A. D., Marquis, K., Larivière, R., Desmeules, S., Lebel, M., Boutouyrie, P., & Agharazii, M. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01200 · Cited by 93
Coming full circle in diabetes mellitus: from complications to initiation
Harcourt, B. E., Penfold, S. A., & Forbes, J. M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.236 · Cited by 91
Accumulation of Advanced Glycation End Products, Measured as Skin Autofluorescence, in Renal Disease
Hartog, J. W. L., de Vries, A. P. J., Lutgers, H. L., Meerwaldt, R., Huisman, R. M., van Son, W. J., de Jong, P. E., & Smit, A. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.037 · Cited by 89
Susceptibility of LDL and its subfractions to glycation
Soran, H., & Durrington, P. N. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328348a43f · Cited by 91
Kidney, heart and brain: three organs targeted by ageing and glycation
Frimat, M., Daroux, M., Litke, R., Nevière, R., Tessier, F. J., & Boulanger, E. (2017) · Clinical Science · doi:10.1042/cs20160823 · Cited by 88
The pathobiology of diabetic vascular complications—cardiovascular and kidney disease
Gray, S. P., & Jandeleit-Dahm, K. A. M. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1146-1 · Cited by 85
Measurement of pentosidine in human plasma protein by a single-column high-performance liquid chromatography method with fluorescence detection
Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.01.022 · Cited by 78
Dietary Advanced Glycation End Products and Cardiometabolic Risk
Luévano‐Contreras, C., Gómez-Ojeda, A., Macías-Cervantes, M. H., & Garay‐Sevilla, M. E. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0891-2 · Cited by 83
Increased Urinary Levels of Pentosidine, Pyrraline and Acrolein Adduct in Type 2 Diabetes.
Daimon, M., Sugiyama, K., Kameda, W., SAITOH, T., Oizumi, T., Hirata, A., Yamaguchi, H., Ohnuma, H., Igarashi, M., & Kato, T. (2003) · Endocrine Journal · doi:10.1507/endocrj.50.61 · Cited by 75
Studies of renal injury III: Lipid-induced nephropathy in type II diabetes
Dominguez, J. H., Tang, N., Xu, W., Evan, A. P., Siakotos, A. N., Agarwal, R., Walsh, J., Deeg, M. A., Pratt, J. H., March, K. L., et al. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00814.x · Cited by 75
Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding
Youssef, S., Nguyen, D. T., Soulis, T., Panagiotopoulos, S., Jerums, G., & Cooper, M. E. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055003907.x · Cited by 74
AGE/RAGE signaling-mediated endoplasmic reticulum stress and future prospects in non-coding RNA therapeutics for diabetic nephropathy
Pathomthongtaweechai, N., & Chutipongtanate, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110655 · Cited by 72
Advanced Glycation End Products and Their Circulating Receptors and Level of Kidney Function in Older Community-Dwelling Women
Semba, R. D., Ferrucci, L., Fink, J. C., Sun, K., Beck, J., Dalal, M., Guralnik, J. M., & Fried, L. P. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.06.018 · Cited by 75
Influence of hemodialysis membrane type on pentosidine plasma level, a marker of “carbonyl stress”
Jadoul, M. Y., Ueda, Y., Yasuda, Y., Saitō, A., Robert, A. R., Ishida, N., Kurokawa, K., de Strihou, C. V. Y., & Miyata, T. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00468.x · Cited by 72
Food advanced glycation end products as potential endocrine disruptors: An emerging threat to contemporary and future generation
Ravichandran, G., Lakshmanan, D. K., Raju, K., Elangovan, A., Nambirajan, G., Devanesan, A. A., & Thilagar, S. (2019) · Environment International · doi:10.1016/j.envint.2018.12.032 · Cited by 70
Low-molecular-weight AGEs are associated with GFR and anemia in patients with type 2 diabetes
Thomas, M. C., Tsalamandris, C., MacIsaac, R. J., Medley, T. L., Kingwell, B. A., Cooper, M. E., Jerums, G., & Alberti, D. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00868.x · Cited by 70
Glucose and Blood Pressure-Dependent Pathways–The Progression of Diabetic Kidney Disease
Patel, D. M., Bose, M., & Cooper, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062218 · Cited by 65
Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy
Chabroux, S., Canouï‐Poitrine, F., Reffet, S., Joncour-Mills, G., Morélon, E., Colin, C., & Thivolet, C. H. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.11.003 · Cited by 61
Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy
Weiss, M. F., Rodby, R. A., Justice, A. C., Hricik, D. E., & the Collaborative Study Group (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00982.x · Cited by 61
C-peptide and diabetic neuropathy
Sima, A. A. F. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.9.1471 · Cited by 60
Differences in kinetics and dynamics of endogenous versus exogenous advanced glycation end products (AGEs) and their precursors
van Dongen, K. C. W., Kappetein, L., Estruch, I. M., Belzer, C., Beekmann, K., & Rietjens, I. M. C. M. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112987 · Cited by 63
Advanced glycosylation end products in skin, serum, saliva and urine and its association with complications of patients with Type 2 diabetes mellitus
Garay‐Sevilla, M. E., Regalado, J. C., Malacara, J. M., Nava, L. E., Wróbel, K., Castro-Rivas, A., & Wróbel, K. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345377 · Cited by 58
Serum Carboxymethyl-Lysine, a Dominant Advanced Glycation End Product, Is Associated With Chronic Kidney Disease: The Baltimore Longitudinal Study of Aging
Semba, R. D., Fink, J. C., Sun, K., Windham, B. G., & Ferrucci, L. (2009) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2009.08.001 · Cited by 58
Advanced Glycation End Products in End-Stage Renal Disease and Their Removal
Schinzel, R., Münch, G. W., Heidland, A., & Šebeková, K. (2001) · The Nephron journals/Nephron journals · doi:10.1159/000045934 · Cited by 57
Advanced Glycation End Products in Clinical Nephrology
Kalousová, M., Zima, T., Tesař, V., Štípek, S., & Sulková, S. (2003) · Kidney & Blood Pressure Research · doi:10.1159/000075533 · Cited by 55
Advanced glycation end product signaling and metabolic complications: Dietary approach
Khan, M. I., Ashfaq, F., Alsayegh, A. A., Hamouda, A., Khatoon, F., Altamimi, T. N. A., Alhodieb, F. S., & Beg, M. M. A. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i7.995 · Cited by 59
Contribution of extracellular matrix components to the stiffness of skeletal muscle contractures in patients with cerebral palsy
Smith, L., Pichika, R., Meza, R. C., Gillies, A. R., Baliki, M. N., Chambers, H. G., & Lieber, R. L. (2019) · Connective Tissue Research · doi:10.1080/03008207.2019.1694011 · Cited by 51
Elevated serum levels of AGEs, sRAGE, and pentosidine in Tunisian patients with severity of diabetic retinopathy
Kerkeni, M., Saïdi, A., Bouzidi, H., Yahya, S. B., & Hammami, M. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.07.006 · Cited by 50
Advanced glycation end products and oxidative stress are increased in chronic allograft nephropathy
Raj, D. S., Lim, G., Levi, M., Qualls, C., & Jain, S. K. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.09.021 · Cited by 50
Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney
Do, M. H., Hur, J., Choi, J., Kim, M. K., Kim, M. J., Kim, Y., & Ha, S. K. (2018) · Nutrients · doi:10.3390/nu10030265 · Cited by 49
Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome
Willemsen, S., Hartog, J. W. L., Heiner-Fokkema, M. R., van Veldhuisen, D. J., & Voors, A. A. (2011) · Heart Failure Reviews · doi:10.1007/s10741-010-9225-z · Cited by 48
Effects of glutamine supplementation on oxidative stress-related gene expression and antioxidant properties in rats with streptozotocin-induced type 2 diabetes
Tsai, P.-H., Liu, J., Yeh, C.-L., Chiu, W., & Yeh, S. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004168 · Cited by 49
Role of Megalin in Endocytosis of Advanced Glycation End Products
Saito, A., Nagai, R., Tanuma, A., Hama, H., Cho, K., Takeda, T., Yoshida, Y., Toda, T., Shimizu, F., Horiuchi, S., et al. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000062962.51879.f8 · Cited by 48
Significance of Proximal Tubular Metabolism of Advanced Glycation End Products in Kidney Diseases
SAITO, A., TAKEDA, T., SATO, K., HAMA, H., TANUMA, A., KASEDA, R., SUZUKI, Y., & GEJYO, F. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.072 · Cited by 48
Carboxymethyl-lysine, an advanced glycation end product, and decline of renal function in older community-dwelling adults
Semba, R. D., Fink, J. C., Sun, K., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0757-0 · Cited by 47
Urinary levels of pentosidine and the risk of fracture in postmenopausal women: the OFELY study
Gineyts, É., Munoz, F., Bertholon, C., Sornay‐Rendu, E., & Chapurlat, R. D. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0939-5 · Cited by 46
Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease
Allen, M. R., Newman, C. L., Chen, N. X., Granke, M., Nyman, J. S., & Moe, S. M. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2978-9 · Cited by 47
Dietary Metabolites and Chronic Kidney Disease
Hasegawa, S., Jao, T., & Inagi, R. (2017) · Nutrients · doi:10.3390/nu9040358 · Cited by 47
Apolipoprotein E2/E5 variants in lipoprotein glomerulopathy recurred in transplanted kidney
MIYATA, T., SUGIYAMA, S., NANGAKU, M., SUZUKI, D., URAGAMI, K.-I., INAGI, R., SAKAI, H., & KUROKAWA, K. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1071590 · Cited by 55
Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease
Hirakawa, Y., Tanaka, T., & Nangaku, M. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12624 · Cited by 43

Authors: Miyata, T., Ueda, Y., Horie, K., Nangaku, M., Tanaka, S., de Strihou, C. V. Y., & Kurokawa, K.
Affiliations: Tokai University (JP)
Corresponding author: Miyata, Toshio
ORCID: Nangaku, Masaomi
Venue: Kidney International
Publisher: Elsevier BV
Published: 1998-02
Volume: 53
Issue: 2
Pages: 416-422
ISSN: 0085-2538 (ISSN-L)
DOI: 10.1046/j.1523-1755.1998.00756.x
OpenAlex: W1998110176
Cited by: 227
References: 26
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 10 · 2018: 4 · 2017: 12 · 2016: 1 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 8
FWCI: 5.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6518 d)
Locations: Kidney International (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (96L00303)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords: advanced glycation end products, pentosidine, Maillard reaction, glomerular filtration, proximal tubule, tubular reabsorption, urinary excretion, renal clearance, protein glycation
MeSH terms: Animals, Anti-Bacterial Agents, Arginine, Chromatography, High Pressure Liquid, Gentamicins, Kidney Diseases, Kidney Glomerulus, Kidney Tubules, Proximal, Lysine, Protein Synthesis Inhibitors, Glycation End Products, Advanced, Rats, Wistar, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Renal catabolism of advanced glycation end products: The fate of pentosidine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks