Lipoprotein glomerulopathy: significance of lipoprotein and ultrastructural features
Open accessAbstract
Background Lipoprotein glomerulopathy (LPG) is a unique disease characterized by intraglomerular lipoprotein thrombi and type III hyperlipoproteinemia. Recently, we have demonstrated that LPG is associated with inherited apolipoprotein E (apoE) variants including apoE Sendai. On the other hand electron microscopy shows that intraglomerular lipoprotein thrombi consist of lipid granules of various sizes. To elucidate the relationship between the peculiar histology and abnormal lipid metabolism related to apoE Sendai, we studied lipoprotein profiles and ultrastructural features. Methods The subjects were 11 patients with LPG. Four patients were nephrotic, and two others became nephrotic within six months following the biopsy. Eight patients underwent apoE gene analysis and showed apoE Sendai. The other three were presumed to have apoE Sendai because this mutation was demonstrated in their kindreds. Under electron microscopy, diameters of more than 1000 lipid granules were measured in several glomeruli, and a mean value was calculated in each case. Lipoprotein profiles were analyzed by the ultracentrifugation methods. Results The mean diameter of intraglomerular lipid granules correlated inversely with the levels of plasma triglyceride (TG; rs = -0.73, P Conclusion These results suggest that the size of lipid granules in LPG may become smaller under the influence of hypertriglyceridemia and particularly elevated plasma VLDL and HDL-TG, which may lead to heavy proteinuria.
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LPG patients present elevated apoE serum levels and often an abnormal lipid profile compared with control subjects.
“LPG patients present elevated apoE serum levels and often an abnormal lipid profi le compared with control subjects (24)(25)(26).”
From Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice (2014) · cites this paper as [25]
LPG patients carrying apoE Sendai may show a lipoprotein profile ranging from near normal to one that resembles type III hyperlipoproteinemia.
“LPG patients carrying apoE Sendai may show a lipoprotein profi le ranging from near normal to one that resembles type III hyperlipoproteinemia (24)(25)(26).”
From Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice (2014) · cites this paper as [25]
Our post-treatment biopsy findings provide evidence to support the hypothesis that precursors of lipoprotein thrombi assemble in the mesangium and/or subendothelium and then build up in the glomerular capillaries.
“Our post-treatment biopsy findings provide evidence to support this hypothesis.”
From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [42]
The subendothelial material contains precursors to lipoprotein thrombi.
“supporting the hypothesis that this subendothelial material contains precursors to lipoprotein thrombi.”
From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [42]
Cites
Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia
Saito, T., Sato, H., Kudo, K.-I., Oikawa, S.-I., Shibata, T., Hara, Y., Yoshinaga, K., & Sakaguchi, H. (1989) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(89)80134-9 · Cited by 148 · see citing works
Self-citationAbnormal Lipoprotein and Apolipoprotein Pattern in Lipoprotein Glomerulopathy
Oikawa, S., Suzuki, N., Sakuma, E., Saito, T., Namai, K., Kotake, H., Fujii, Y., & Toyota, T. (1991) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80649-4 · Cited by 60 · see citing works
Self-citationSaito, T., Sato, H., Oikawa, S., Kudo, K., Kurihara, I., Nakayama, K., Abe, K., Yoshinaga, K., & Sakaguchi, H. (1993) · American Journal of Nephrology · doi:10.1159/000168591 · Cited by 57 · see citing works
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Apolipoprotein E–related glomerular disorders
Saito, T., Matsunaga, A., Fukunaga, M., Nagahama, K., Hara, S., & Muso, E. (2020) · Kidney International · doi:10.1016/j.kint.2019.10.031 · Cited by 77 · see citing works
Self-citationArai, T., Yamashita, S., Yamane, M., Manabe, N., Matsuzaki, T., Kiriyama, K., Kanayama, Y., Himeno, S., & Matsuzawa, Y. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00194-1 · Cited by 43 · see citing works
Tsimihodimos, V., & Elisaf, M. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328345ebb0 · Cited by 33 · see citing works
Fukunaga, M., Nagahama, K., Aoki, M., Shimizu, A., Hara, S., Matsunaga, A., Muso, E., & Saito, T. (2018) · Case Reports in Nephrology and Dialysis · doi:10.1159/000487919 · Cited by 14 · see citing works
Self-citationTavori, H., Fan, D., Giunzioni, I., Zhu, L., Linton, M. F., Fogo, A. B., & Fazio, S. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m049874 · Cited by 10 · see citing works
Lipoprotein Glomerulopathy, First Case Report from Canada
Ting, J. A., McRae, S. A., Schwartz, D., Barbour, S. J., & Riazy, M. (2022) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s364890 · Cited by 7 · see citing works
- Authors
- Saito, T., Oikawa, S., Sato, H., Sato, T., Ito, S., & Sasaki, J.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Saito, Takao
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 56
- Pages
- S37-S41
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2065455829
- Cited by
- 37
- References
- 3
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 3 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- lipoprotein glomerulopathy, type III hyperlipoproteinemia, hypertriglyceridemia, VLDL, HDL triglycerides, nephrotic syndrome, proteinuria, glomerular ultrastructure, lipoprotein profile
- MeSH terms
- Adolescent, Adult, Apolipoproteins B, Apolipoproteins E, Child, Female, Histocytochemistry, Humans, Kidney Diseases, Kidney Glomerulus, Lipids, Lipoproteins, Male, Microscopy, Electron, Middle Aged
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