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The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia
Open accessAbstract
Cardiovascular disease is the leading cause of mortality in uremic patients. In large cross-sectional studies of dialysis patients, traditional cardiovascular risk factors such as hypertension and hypercholesterolemia have been found to have low predictive power, while markers of inflammation and malnutrition are highly correlated with cardiovascular mortality. However, the pathophysiology of the disease process that links uremia, inflammation, and malnutrition with increased cardiovascular complications is not well understood. We hereby propose the hypothesis that increased oxidative stress and its sequalae is a major contributor to increased atherosclerosis and cardiovascular morbidity and mortality found in uremia. This hypothesis is based on studies that conclusively demonstrate an increased oxidative burden in uremic patients, before and particularly after renal replacement therapies, as evidenced by higher concentrations of multiple biomarkers of oxidative stress. This hypothesis also provides a framework to explain the link that activated phagocytes provide between oxidative stress and inflammation (from infectious and non-infections causes) and the synergistic role that malnutrition (as reflected by low concentrations of albumin and/or antioxidants) contributes to the increased burden of cardiovascular disease in uremia. We further propose that retained uremic solutes such as beta-2 microglobulin, advanced glycosylated end products (AGE), cysteine, and homocysteine, which are substrates for oxidative injury, further contribute to the pro-atherogenic milieu of uremia. Dialytic therapy, which acts to reduce the concentration of oxidized substrates, improves the redox balance. However, processes related to dialytic therapy, such as the prolonged use of catheters for vascular access and the use of bioincompatible dialysis membranes, can contribute to a pro-inflammatory and pro-oxidative state and thus to a pro-atherogenic state. Anti-oxidative therapeutic strategies for patients with uremia are in their very early stages; nonetheless, early studies demonstrate the potential for significant efficacy in reducing cardiovascular complications.
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“The uncoupling of endothelial nitric oxide synthase (eNOS), oxidative stress mechanism is involved in uremia, a condition when the kidney does not work properly and waste products instead of urine are excreted into the bloodstream (Himmelfarb et al. 2002).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Himmelfarb et al. 2002
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Cites
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Clinical epidemiology of cardiovascular disease in chronic renal disease
Rn, F., Parfrey, P. S., & Sarnak, M. J. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9820470 · Cited by 3,960
Klahr, S., Levey, A. S., Beck, G. J., Caggiula, A. W., Hunsicker, L., Kusek, J. W., & Striker, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301301 · Cited by 2,328
Dietary Protein Intake and the Progressive Nature of Kidney Disease:
Epstein, F. H., Brenner, B. M., Meyer, T. W., & Hostetter, T. H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209093071104 · Cited by 2,067
Advanced oxidation protein products as a novel marker of oxidative stress in uremia
Witko‐Sarsat, V., Friedlander, M. A., Capeillère‐Blandin, C., Nguyen‐Khoa, T., Nguyen, A., Zingraff, J., Jungers, P., & Descamps‐Latscha, B. (1996) · Kidney International · doi:10.1038/ki.1996.186 · Cited by 2,000
Lowrie, E. G., & Lew, N. L. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70364-5 · Cited by 1,965
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898
Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
Stenvinkel, P., Heimbürger, O., Paultre, F., Diczfalusy, U., Wang, T., Berglund, L., & Jogestrand, T. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00422.x · Cited by 1,767
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Research works printed but not linked: 1
- Bloembergen, 1995, The relationship of dialysis membrane and cause-specific mortality in chronic hemodialysis patients, J Am Soc Nephrol, 6, 521
Cited by
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Items 601–700 of 1,000
Tepel, M. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg201 · Cited by 21
Consensus clinical recommendations for the management of plasma lipid disorders in the Middle East
Sayed, N., Waili, K. A., Alawadi, F., Al-Ghamdi, S. M. G., Almahmeed, W. A., Alnouri, F., Rukhaimi, M. A., Al‐Rasadi, K., Awan, Z. A., Farghaly, M., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.09.081 · Cited by 22
End-stage renal failure is associated with impaired coronary microvascular function
Nelson, A. J., Dundon, B. K., Worthley, S. G., Richardson, J. D., Puri, R., Wong, D. T. L., Coates, P. T., Faull, R., & Worthley, M. I. (2019) · Coronary Artery Disease · doi:10.1097/mca.0000000000000727 · Cited by 21
Sphingosine-1-phosphate: From insipid lipid to a key regulator
Spiegel, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.x120.012838 · Cited by 21
ApoA-1 Mimetic Peptide Reverses Uremia-Induced Upregulation of Pro-Atherogenic Pathways in the Aorta
Vaziri, N. D., Bai, Y., Yuan, J. J., Said, H. L., Sigala, W., & Ni, Z. (2010) · American Journal of Nephrology · doi:10.1159/000316479 · Cited by 21
Decreased Hypoxia-Inducible Factor-1α in Gastrocnemius Muscle in Rats with Chronic Kidney Disease
Flisiński, M., Brymora, A., Bartłomiejczyk, I., Wiśniewska, E., Gołda, R., Stefańska, A., Pączek, L., & Manitius, J. (2012) · Kidney & Blood Pressure Research · doi:10.1159/000339706 · Cited by 21
Inflammation in Uremic Patients: What Is the Link?
Galle, J., Seibold, S., & Wanner, C. (2003) · Kidney & Blood Pressure Research · doi:10.1159/000070986 · Cited by 21
Georgopoulou, G. A., Papasotiriou, M., Bosgana, P., de Lastic, A.-L., Koufou, E., Papachristou, E. C., Goumenos, D. S., Davlouros, P. A., Kourea, E. P., Zolota, V., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12020368 · Cited by 23
Soomro, Q. H., & Charytan, D. M. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000686 · Cited by 21
Association of the serum albumin level with prognosis in chronic kidney disease patients
Song, H., Wei, C., Hu, H., & Wan, Q. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03140-5 · Cited by 20
Tissue Sodium Accumulation Induces Organ Inflammation and Injury in Chronic Kidney Disease
Ito, Y., Sun, T., Tanaka, H., Yamaguchi, M., Kinashi, H., Sakata, F., Kunoki, S., Sakai, Y., & Ishimoto, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098329 · Cited by 22
Watral, J., Formanowicz, D., Perek, B., Kostka-Jeziorny, K., Podkowińska, A., Tykarski, A., & Łuczak, M. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1229648 · Cited by 20
Pawlak, K., Pawlak, D., & Myśliwiec, M. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.02.004 · Cited by 20
Liu, S., Zhang, D., Guo, W., Cui, W., & Liu, W. (2012) · Hemodialysis International · doi:10.1111/j.1542-4758.2012.00700.x · Cited by 20
Miyamoto, T., Qureshi, A. R., Yamamoto, T., Nakashima, A., Lindholm, B., Stenvinkel, P., Alvestrand, A., & Axelsson, J. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq697 · Cited by 21
Self-citationPleiotropic Effects of Sevelamer Beyond Phosphate Binding in End-Stage Renal Disease Patients
Lin, Y., Chien, C., Kan, W., Chen, Y., Chu, T., Hung, K., Tsai, T., Wu, K., & Wu, M. (2011) · Clinical Drug Investigation · doi:10.2165/11539120-000000000-00000 · Cited by 20
Jiang, H., Li, J., Yu, K., Yang, H., Min, X., Chen, H., & Wu, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-09591-6 · Cited by 19
Nakayama, M., Itami, N., Suzuki, H., Hamada, H., Osaka, N., Yamamoto, R., Tsunoda, K., Nakano, H., Watanabe, K., Zhu, W.-J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184535 · Cited by 20
Kanbay, M., Yerlikaya, A., Sag, A. A., Ortíz, A., Kuwabara, M., Covic, A. C., Więcek, A., Stenvinkel, P., & Afşar, B. (2019) · Clinical Kidney Journal · doi:10.1093/ckj/sfz106 · Cited by 21
Self-citationPravda, M. S., Cohen‐Hagai, K., Topaz, G., Pravda, N. S., Makhoul, N., Shuvy, M., Benchetrit, S., Assali, A., & Pereg, D. (2020) · American Journal of Nephrology · doi:10.1159/000508836 · Cited by 20
Lin, C., Chen, S., Sung, C., Lin, C., Lin, S., Cheng, S., Wang, I., Huang, W.-S., & Kao, C. (2015) · Medicine · doi:10.1097/md.0000000000001164 · Cited by 20
Reno-cerebrovascular disease: linking the nephron and neuron
Lee, M., & Ovbiagele, B. I. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.204 · Cited by 19
Schreier, S. M., Steinkellner, H., Jirovetz, L., Hermann, M., Exner, M., Gmeiner, B. M. K., Kapiotis, S., & Laggner, H. (2011) · Biochimie · doi:10.1016/j.biochi.2011.01.007 · Cited by 20
Precision of Biomarkers to Define Chronic Inflammation in CKD
LaClair, R. E., O’Neal, K., Ofner, S., Sosa, M. J., Labarrere, C. A., & Moe, S. M. (2008) · American Journal of Nephrology · doi:10.1159/000135692 · Cited by 20
Naeini, A. E., Moeinzadeh, F., Vahdat, S., Ahmadi, A., Hedayati, Z. P., & Shahzeidi, S. (2017) · Journal of Research in Pharmacy Practice · doi:10.4103/2279-042x.200994 · Cited by 20
Genomic damage in chronic renal failure—potential therapeutic interventions
Stopper, H., Schupp, N., Klassen, A., Šebeková, K., & Heidland, A. (2005) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2004.09.017 · Cited by 20
Avcı, E., Cevher, Ş. C., Çakır, E., Kurt, Y., Akgül, E. Ö., & Bilgi, C. (2008) · Renal Failure · doi:10.1080/08860220802249009 · Cited by 19
Lorenzen, J. M., David, S., Richter, A., de Groot, K., Kielstein, J. T., Haller, H. G., Thum, T., & Fliser, D. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq758 · Cited by 19
Colombo, G., Reggiani, F., Cucchiari, D., Portinaro, N. M., Giustarini, D., Rossi, R., Garavaglia, M. L., Saino, N., Milzani, A., Badalamenti, S., et al. (2017) · BBA Clinical · doi:10.1016/j.bbacli.2016.12.004 · Cited by 19
Fanti, P., Giustarini, D., Rossi, R., Cunningham, S. E. D., Folli, F. B., Khazim, K., Cornell, J. E., Matteucci, E., & Bansal, S. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2015.06.003 · Cited by 19
Uremic cardiomyopathy: role of circulating digitalis like substances
Behram, M. (2005) · Frontiers in bioscience · doi:10.2741/1679 · Cited by 19
Incidence and Risk Factors of Coronary Artery Disease in Patients on Chronic Hemodialysis
Soubassi, L. P., Papadakis, E. D., Theodoropoulos, I., Poulos, G., Chaniotis, D. I., Tsapakidis, I. P., Zerefos, S. N., Douli, M., Chiras, T. C., Kouvelis, A., et al. (2007) · The International Journal of Artificial Organs · doi:10.1177/039139880703000311 · Cited by 19
Lichtenberg, S., Korzets, A., Zingerman, B. V., Green, H., Erman, A., Gafter, U., & Rozen‐Zvi, B. (2015) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000411 · Cited by 19
Pathophysiological and clinical aspects of malnutrition in chronic renal failure
Caimi, G., Carollo, C., & Presti, R. L. (2005) · Nutrition Research Reviews · doi:10.1079/nrr200599 · Cited by 19
Nutritional Management of Maintenance Hemodialysis Patients
Kalantar‐Zadeh, K., & Kopple, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391934-2.00032-1 · Cited by 19
Editorials: Antioxidant Therapy in Uremia: Evidence‐Based Medicine?
Gordon, C. A., & Himmelfarb, J. (2004) · Seminars in Dialysis · doi:10.1111/j.0894-0959.2004.17357.x · Cited by 19
Self-citationDetermination of parathyroid hormone: from radioimmunoassay to LCMS/MS
Cavalier, E. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-0942 · Cited by 18
Jin, Y.-X., Zhang, S., Xiao, J., Wang, Z., Cui, D., You, L.-L., Kuai, T.-T., Zhang, Y., & Liu, S. (2023) · BMC Nephrology · doi:10.1186/s12882-023-03191-5 · Cited by 18
Conformational Changes of Blood ACE in Chronic Uremia
Petrov, M. N., Shilo, V. Y., Tarasov, A. V., Schwartz, D. E., Garcia, J. G. N., Kost, O. A., & Danilov, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049290 · Cited by 18
Serum Protein Thiol Levels in Patients with Hospital-Acquired Acute Kidney Injury
Qian, J., Fang, J., Zhu, Q., Ma, S., Wang, W., Zheng, Y., Hao, G., Deng, B., Zhao, X., & Ding, F. H. (2015) · Kidney & Blood Pressure Research · doi:10.1159/000368538 · Cited by 18
Safety of intravenous iron in hemodialysis patients
Li, X., Kshirsagar, A. V., & Brookhart, M. A. (2017) · Hemodialysis International · doi:10.1111/hdi.12558 · Cited by 18
Serum heat shock protein 27 levels predict cardiac mortality in hemodialysis patients
Jaroszyński, A., Jaroszyńska, A., Zaborowski, T., Drelich‐Zbroja, A., Zapolski, T., & Dąbrowski, W. (2018) · BMC Nephrology · doi:10.1186/s12882-018-1157-1 · Cited by 18
Bhandari, S. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4958 · Cited by 18
Carbamoylation abrogates the antioxidant potential of hydrogen sulfide
Praschberger, M., Hermann, M., Laggner, C., Jirovetz, L., Exner, M., Kapiotis, S., Gmeiner, B. M. K., & Laggner, H. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.018 · Cited by 18
Progression of Chronic Kidney Disease: Mechanisms and Interventions in Retardation
Balasubramanian, S. (2013) · Apollo Medicine · doi:10.1016/j.apme.2013.01.009 · Cited by 18
Does Dialysis Modality Influence the Oxidative Stress of Uremic Patients?
Căpuşă, C. S., Stoian, I. A.-M., Rus, E., Lixandru, D., Barbulescu, C., & Mircescu, G. (2012) · Kidney & Blood Pressure Research · doi:10.1159/000331560 · Cited by 18
N-Acetylcysteine Improves Arterial Vascular Reactivity in Patients with Chronic Kidney Disease
Wittstock, A., Burkert, M., Zidek, W., Tepel, M., & Scholze, A. (2009) · Nephron Clinical Practice · doi:10.1159/000218107 · Cited by 18
Oxidised LDL/LDL-cholesterol ratio and coronary artery calcification in haemodialysis patients
Asamiya, Y., Yajima, A., Tsuruta, Y., Otsubo, S., & Nitta, K. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.02.001 · Cited by 18
Cholesterol in end-stage renal disease: the good, the bad or the ugly?
Diepeveen, S. H. A., Wetzels, J. F. M., Bilo, H. J. G., van Tits, L. J. H., & Stalenhoef, A. F. H. (2008) · PubMed · Cited by 18
Park, H. S., Kim, C. J., Hwang, B., Kim, T., Koh, Y. S., Park, H., Her, S., Jang, S. W., Park, C., Lee, J. M., et al. (2016) · Scientific Reports · doi:10.1038/srep35774 · Cited by 18
Pawlak, K., Pawlak, D., Brzόsko, S., & Myśliwiec, M. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.07.003 · Cited by 18
Terawaki, H., Matsuyama, Y., Era, S., Matsuo, N., Ikeda, M., Ogura, M., Yokoyama, K., Yamamoto, H., Hosoya, T., & Nakayama, M. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl635 · Cited by 18
Acute effect of haemodialysis on arterial stiffness: membrane bioincompatibility?
Mourad, A. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh443 · Cited by 18
Hyperuricemia Is an Independent Risk Factor for Mortality Only if Chronic Kidney Disease Is Present
Chung, W., Kim, A. J., Ro, H., Chang, J. H., Lee, H. H., & Jung, J. Y. (2013) · American Journal of Nephrology · doi:10.1159/000350534 · Cited by 17
Serum Levels of α-Klotho, Inflammation-Related Cytokines, and Mortality in Hemodialysis Patients
Lisowska, K. A., Storoniak, H., Soroczyńska‐Cybula, M., Maziewski, M., & Dębska-Ślizień, A. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216518 · Cited by 17
Bal, Z., Bal, U. A., Okyay, K., Yılmaz, M., Balcıoğlu, S., Yıldırım, Ö. T., Hasırcı, S. H., Aydınalp, A., Yı́ldı́rı́r, A., Sezer, S., et al. (2015) · International Urology and Nephrology · doi:10.1007/s11255-015-1073-2 · Cited by 17
Henning, B. F., Holzhausen, H., & Tepel, M. (2010) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1744-9987.2010.00844.x · Cited by 17
Oxidative stress biomarkers and chromogranin A in uremic patients: Effects of dialytic treatment
Castoldi, G., Antolini, L., Bombardi, C., Perego, L., Mariani, P., Viganò, M. R., Torti, G., Casati, M., Corti, A., Zerbini, G., et al. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.08.028 · Cited by 17
N‐Acetylcysteine Use for Amelioration of Aminoglycoside‐Induced Ototoxicity in Dialysis Patients
Feldman, L., Sherman, R. A., & Weissgarten, J. (2012) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2012.01090.x · Cited by 17
Wang, C., Wang, Y.-C., Wang, G., Shen, M., Chang, Y.-L., Liou, S.-Y., Chen, H.-C., Lee, A., Chang, K., Chen, W., et al. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0495-9 · Cited by 17
Cystatin C, Other Markers of Kidney Disease, and Incidence of Age-Related Cataract
Klein, R. (2008) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2008.502 · Cited by 17
Approaches to inverse-probability-of-treatment–weighted estimation with concurrent treatments
Ellis, A. R., & Brookhart, M. A. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.03.020 · Cited by 17
Fighting Protein-Energy Wasting in Chronic Kidney Disease: A Challenge of Complexity
Guarnieri, G., & Barazzoni, R. (2011) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2010.10.008 · Cited by 17
F2-Isoprostanes in Kidney Transplant Patients: Relationship With Inflammatory Markers
Lauzurica, R., Pastor, M. C., Bayés, B., Hernández, J., Bonet, J., Llopis, M. A., Carrera, L. B., & Romero, R. (2005) · Transplantation Proceedings · doi:10.1016/j.transproceed.2005.09.106 · Cited by 17
Extracellular Water Expansion: Part of the Malnutrition– Inflammation–Atherosclerosis Syndrome?
Woodrow, G. (2006) · Peritoneal Dialysis International · doi:10.1177/089686080602600508 · Cited by 17
Cardiovascular Risk in Peritoneal Dialysis
Prichard, S. S. (2003) · KARGER eBooks · doi:10.1159/000071427 · Cited by 17
Chen, J., Hamm, L. L., Bundy, J. D., Kumbala, D. R., Bodana, S., Chandra, S., Chen, C.-S., Starcke, C. C., Guo, Y., Schaefer, C. M., et al. (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02020220 · Cited by 16
Morales, J. J., Korucu, B., Pike, M., Lipworth, L. P., Stewart, T. G., Headley, S., Germain, M., Begue, G., Roshanravan, B., Tuttle, K. R., et al. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00270.2021 · Cited by 16
Self-citationZhang, Y., Zhang, A., Wei, L., Ren, K., Wang, Q., Shao, B., Zhao, C., Ren, Z., Bai, J.-X., & Cao, N. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2258228 · Cited by 15
Rossi, S. H., McQuarrie, E. P., Miller, W. H., Mackenzie, R. M., Dymott, J. A., Moreno, M. U., Taurino, C., Miller, A. M., Neisius, U., Berg, G. A., et al. (2013) · BMC Nephrology · doi:10.1186/1471-2369-14-173 · Cited by 16
Granata, S., Gassa, A. D., Bellin, G., Lupo, A., & Zaza, G. (2016) · BioMed Research International · doi:10.1155/2016/9290857 · Cited by 16
TopciuShufta, V., Miftari, R., Haxhibeqiri, V., & Haxhibeqiri, S. (2016) · Medical Archives · doi:10.5455/medarh.2016.70.348-350 · Cited by 16
Satta, H., Iwamoto, T., Kawai, Y., Koguchi, N., Shibata, K., Kobayashi, N., Yoshida, M., & Nakayama, M. (2021) · Renal Replacement Therapy · doi:10.1186/s41100-021-00353-9 · Cited by 16
Adiponectin as a novel indicator of malnutrition and inflammation in hemodialysis patients.
Ekramzadeh, M., Sohrabi, Z., Salehi, M., Ayatollahi, M., Hassanzadeh, J., Geramizadeh, B., & Sagheb, M. M. (2013) · Iranian Journal of Kidney Diseases · Cited by 16
["Malnutrition-inflammation complex syndrome" in chronic hemodialysis].
Young, P., Lombi, F., Finn, B. C., Forrester, M., Campolo-Girard, V., Pomeranz, V., Iriarte, R., Bruetman, J. E., & Trimarchi, H. (2011) · PubMed · Cited by 16
Malondialdehyde can predict survival in hemodialysis patients
Rusu, C. C., Racasan, S., Kacsó, I. M., Moldovan, D. T., Potra, A. R., Pațiu, I. M., Vlăduțiu, D., & Caprioara, M. G. (2015) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-537 · Cited by 16
Masuda, A., Hagiwara, S., Tanimoto, M., Kodama, F., Okumura, K., Nohara, N., Matsumoto, M., Maiguma, M., Omote, K., Io, H., et al. (2012) · Nephron Extra · doi:10.1159/000342258 · Cited by 16
Stack, A. G., Donigiewicz, U., Abdalla, A. A., Weiland, A., Casserly, L. F., Cronin, C. J., Nguyen, H., & Hannigan, A. (2014) · QJM · doi:10.1093/qjmed/hcu057 · Cited by 16
Bossola, M., Tazza, L., Merki, E., Giungi, S., Luciani, G., Miller, E. R., Lin, E. B., Tortorelli, A. P., & Tsimikas, S. (2007) · Blood Purification · doi:10.1159/000112465 · Cited by 16
Krueger, K., Shen, J., Maier, A., Tepel, M., & Scholze, A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7423249 · Cited by 16
A new insight into the treatment of renal anemia with HIF stabilizer
Kuriyama, S., Maruyama, Y., & Honda, H. (2020) · Renal Replacement Therapy · doi:10.1186/s41100-020-00311-x · Cited by 16
Superoxide dismutase type 1 in monocytes of chronic kidney disease patients
Scholze, A., Krueger, K., Diedrich, M., Räth, C., Torges, A., Jankowski, V., Maier, A., Thilo, F., Zidek, W., & Tepel, M. (2010) · Amino Acids · doi:10.1007/s00726-010-0763-4 · Cited by 16
Park, J. S., & Kim, S. B. (2003) · Nephrology · doi:10.1046/j.1440-1797.8.s.8.x · Cited by 16
Pawlak, K., Pawlak, D., & Myśliwiec, M. (2004) · American Journal of Nephrology · doi:10.1159/000082936 · Cited by 16
Oxidative stress in primary glomerular diseases: a comparative study
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Metadata
- Authors
- Himmelfarb, J., Stenvinkel, P., Ikizler, T. A., & Hakim, R. M.
- Affiliations
- Maine Medical Center (US)
- Corresponding author
- Himmelfarb, Jonathan
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 62
- Issue
- 5
- Pages
- 1524-1538
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1996978408
- Cited by
- 1,179
- References
- 294
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 29 · 2023: 31 · 2022: 36 · 2021: 51 · 2020: 40 · 2019: 30 · 2018: 43 · 2017: 57 · 2016: 49 · 2015: 57 · 2014: 58 · 2013: 71 · 2012: 68
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- uremia, oxidative stress, cardiovascular disease, atherosclerosis, inflammation, malnutrition, dialysis, uremic solutes, beta2-microglobulin, homocysteine, cysteine, antioxidant therapy, vascular access catheters, cardiovascular mortality
- MeSH terms
- Cardiovascular Diseases, Humans, Uremia, Oxidative Stress
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