Relevance of Oxidative Pathways in the Pathophysiology of Chronic Kidney Disease

Himmelfarb, Jonathan

doi:10.1016/j.ccl.2005.03.005

Cited by 81Dialysis and Renal Disease ManagementAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Relevance of Oxidative Pathways in the Pathophysiology of Chronic Kidney Disease

Himmelfarb, Jonathan·2005·Cardiology Clinics

DOI 10.1016/j.ccl.2005.03.005

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Abstract

Patients with uremia (whether requiring renal replacement therapy or not) have a greatly increased cardiovascular risk that cannot be explained entirely by traditional cardiovascular risk factors. An increase in oxidative stress has been proposed as a nontraditional cardiovascular risk factor in this patient population. Using a wide variety of different biomarkers of increased oxidative stress status, numerous laboratories around the world have now unequivocally demonstrated that uremia is a state of increased oxidative stress. Recent data also suggest linkages between oxidative stress inflammation, endothelial dysfunction, and malnutrition in the uremic population. These factors are probably synergistic in their effects on atherogenecity and risk of a cardiovascular event. The pathophysiology of increased oxidative stress in uremia is multifactorial, but the retention of oxidized solute by the loss of kidney function is probably a major contributor. Uremic oxidative stress can be characterized biologically by an increase in lipid per oxidation products and reactive aldehyde groups as well as by increased retention of oxidized thiols. Two recently published studies have suggested that antioxidative therapy may be particularly promising in reducing cardiovascular events in this patient population.Further definitive studies of antioxidant use are greatly needed.

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Direct involvement of oxidative stress in pathophysiology of kidney diseases involves impaired renal function.
“Direct involvement of oxidative stress in the pathophysiology of kidney diseases involves impaired renal function (Himmelfarb 2005).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Himmelfarb 2005

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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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Authors: Himmelfarb, J.
Affiliations: Maine Medical Center (US)
Corresponding author: Himmelfarb, Jonathan
ORCID: Himmelfarb, Jonathan
Venue: Cardiology Clinics
Publisher: Elsevier BV
Published: 2005-08
Volume: 23
Issue: 3
Pages: 319-330
ISSN: 0733-8651 (ISSN-L)
DOI: 10.1016/j.ccl.2005.03.005
OpenAlex: W2118265549
Cited by: 81
References: 101
Citations by year: 2026: 2 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 3
FWCI: 0.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cardiology Clinics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: chronic kidney disease, uremia, oxidative stress, cardiovascular risk, oxidative stress biomarkers, lipid peroxidation, endothelial dysfunction, inflammation, malnutrition, atherogenesis, antioxidant therapy, renal replacement therapy
MeSH terms: Acute-Phase Reaction, Antioxidants, Chronic Disease, Endothelium, Vascular, Renal Dialysis, Humans, Kidney Diseases, Oxidative Stress, Malnutrition, Atherosclerosis

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Relevance of Oxidative Pathways in the Pathophysiology of Chronic Kidney Disease

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