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The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia
Open accessAbstract
Cardiovascular disease is the leading cause of mortality in uremic patients. In large cross-sectional studies of dialysis patients, traditional cardiovascular risk factors such as hypertension and hypercholesterolemia have been found to have low predictive power, while markers of inflammation and malnutrition are highly correlated with cardiovascular mortality. However, the pathophysiology of the disease process that links uremia, inflammation, and malnutrition with increased cardiovascular complications is not well understood. We hereby propose the hypothesis that increased oxidative stress and its sequalae is a major contributor to increased atherosclerosis and cardiovascular morbidity and mortality found in uremia. This hypothesis is based on studies that conclusively demonstrate an increased oxidative burden in uremic patients, before and particularly after renal replacement therapies, as evidenced by higher concentrations of multiple biomarkers of oxidative stress. This hypothesis also provides a framework to explain the link that activated phagocytes provide between oxidative stress and inflammation (from infectious and non-infections causes) and the synergistic role that malnutrition (as reflected by low concentrations of albumin and/or antioxidants) contributes to the increased burden of cardiovascular disease in uremia. We further propose that retained uremic solutes such as beta-2 microglobulin, advanced glycosylated end products (AGE), cysteine, and homocysteine, which are substrates for oxidative injury, further contribute to the pro-atherogenic milieu of uremia. Dialytic therapy, which acts to reduce the concentration of oxidized substrates, improves the redox balance. However, processes related to dialytic therapy, such as the prolonged use of catheters for vascular access and the use of bioincompatible dialysis membranes, can contribute to a pro-inflammatory and pro-oxidative state and thus to a pro-atherogenic state. Anti-oxidative therapeutic strategies for patients with uremia are in their very early stages; nonetheless, early studies demonstrate the potential for significant efficacy in reducing cardiovascular complications.
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“The uncoupling of endothelial nitric oxide synthase (eNOS), oxidative stress mechanism is involved in uremia, a condition when the kidney does not work properly and waste products instead of urine are excreted into the bloodstream (Himmelfarb et al. 2002).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Himmelfarb et al. 2002
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Cites
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Clinical epidemiology of cardiovascular disease in chronic renal disease
Rn, F., Parfrey, P. S., & Sarnak, M. J. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9820470 · Cited by 3,960
Klahr, S., Levey, A. S., Beck, G. J., Caggiula, A. W., Hunsicker, L., Kusek, J. W., & Striker, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301301 · Cited by 2,328
Dietary Protein Intake and the Progressive Nature of Kidney Disease:
Epstein, F. H., Brenner, B. M., Meyer, T. W., & Hostetter, T. H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209093071104 · Cited by 2,067
Advanced oxidation protein products as a novel marker of oxidative stress in uremia
Witko‐Sarsat, V., Friedlander, M. A., Capeillère‐Blandin, C., Nguyen‐Khoa, T., Nguyen, A., Zingraff, J., Jungers, P., & Descamps‐Latscha, B. (1996) · Kidney International · doi:10.1038/ki.1996.186 · Cited by 2,000
Lowrie, E. G., & Lew, N. L. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)70364-5 · Cited by 1,965
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898
Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
Stenvinkel, P., Heimbürger, O., Paultre, F., Diczfalusy, U., Wang, T., Berglund, L., & Jogestrand, T. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00422.x · Cited by 1,767
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Research works printed but not linked: 1
- Bloembergen, 1995, The relationship of dialysis membrane and cause-specific mortality in chronic hemodialysis patients, J Am Soc Nephrol, 6, 521
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Huang, M., Zheng, L., Xu, H., Tang, D., Lin, L., Zhang, J., Li, C., Wang, W., Yuan, Q., Tao, L., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.12.006 · Cited by 93
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McMenamin, M. E., Himmelfarb, J., & Nolin, T. D. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.05.046 · Cited by 90
Self-citationModification of cardiovascular risk in hemodialysis patients: An evidence‐based review
Johnson, D. W., Craven, A., & Isbel, N. M. (2007) · Hemodialysis International · doi:10.1111/j.1542-4758.2007.00146.x · Cited by 89
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Kon, V., Linton, M. F., & Fazio, S. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.157 · Cited by 89
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Wang, D., Strandgaard, S., Børresen, M. L., Luo, Z., Connors, S. G., Yan, Q., & Wilcox, C. S. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.09.020 · Cited by 88
Oh, H. J., Nam, B. Y., Lee, M. J., Kim, C. H., Koo, H. M., Doh, F. M., Han, J. H., Kim, E. J., Han, J. S., Park, J. T., et al. (2014) · Peritoneal Dialysis International · doi:10.3747/pdi.2013.00150 · Cited by 86
Agarwal, R. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00289.2005 · Cited by 84
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Self-citationStockler‐Pinto, M. B., Mafra, D., Moraes, C., Lobo, J. C., Boaventura, G. T., Farage, N. E., da Silva, W. S., Cozzolino, S. M. F., & Malm, O. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-9904-z · Cited by 83
Ovbiagele, B. I., Wing, J. J., Menon, R. S., Burgess, R. E., Gibbons, M. C., Sobotka, I., German, L., Shara, N. M., Fernandez, S. J., Jayam‐Trouth, A., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.001958 · Cited by 85
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Lim, C. S., & Vaziri, N. D. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00580.x · Cited by 80
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Diepeveen, S. H. A., VERHOEVEN, G. W. H. E., van der Palen, J. A. M., Dikkeschei, L. D., van Tits, L. J., Kolsters, G., Offerman, J. J. G., Bilo, H. J. G., & Stalenhoef, A. F. H. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01484.x · Cited by 80
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Secondary Hyperparathyroidism: Pathogenesis and Latest Treatment
Mizobuchi, M., Ogata, E., & Koiwa, F. (2018) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12772 · Cited by 79
Juni, R. P., Al‐Shama, R., Kuster, D. W. D., van der Velden, J., Hamer, H. M., Vervloet, M. G., Eringa, E. C., Koolwijk, P., & van Hinsbergh, V. W. M. (2020) · Kidney International · doi:10.1016/j.kint.2020.12.013 · Cited by 79
Chariyavilaskul, P., Dhaun, N., Melville, V., Blackwell, S., Talwar, D. K., Liebman, B., Asai, T., Pollock, J. S., Goddard, J. G., & Webb, D. J. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.01.045 · Cited by 79
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Koç, M., Richards, H. B., Bihorac, A., Ross, E. A., Schold, J. D., & Segal, M. S. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00173.x · Cited by 79
Liu, C., Gidlund, E., Witasp, A., Qureshi, A. R., Söderberg, M. P., Thorell, A., Nader, G. A., Barany, P. F., Stenvinkel, P., & von Walden, F. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00202.2019 · Cited by 83
Self-citationSiracusa, C., Carabetta, N., Morano, M. B., Manica, M., Strangio, A., Sabatino, J., Leo, I., Castagna, A., Cianflone, E., Torella, D., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313096 · Cited by 87
Yao, Q., Lindholm, B., & Stenvinkel, P. (2004) · Hemodialysis International · doi:10.1111/j.1492-7535.2004.01085.x · Cited by 78
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Self-citationBro, S., Moeller, F., Andersen, C. B., Ølgaard, K., & Nielsen, L. B. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000128371.33195.7b · Cited by 78
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Rysz, J., Franczyk, B., Ławiński, J., & Gluba-Brzózka, A. (2020) · Antioxidants · doi:10.3390/antiox9111079 · Cited by 75
Hong, C., Zhu, H., Zhou, X., Zhai, X., Li, S., Ma, W., Liu, K., Shirai, K., Sheerah, H. A., & Cao, J. (2023) · Nutrients · doi:10.3390/nu15020461 · Cited by 73
Rodrigues, S. D., Batista, G. B., Ingberman, M., Pecoits‐Filho, R., & Nakao, L. S. (2012) · Blood Purification · doi:10.1159/000342627 · Cited by 75
Kalk, P., Godes, M., Relle, K., Rothkegel, C., Hucke, A., Stasch, J., & Hocher, B. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706792 · Cited by 74
Busch, M., Fleck, C., Wolf, G., & Stein, G. (2006) · Amino Acids · doi:10.1007/s00726-005-0268-8 · Cited by 74
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Trirogoff, M. L., Shintani, A., Himmelfarb, J., & Ikizler, T. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1642 · Cited by 74
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Pupim, L. B., Flakoll, P. J., & Ikizler, T. A. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000128969.86268.c0 · Cited by 73
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Aveles, P. R., Criminácio, C. R., Gonçalves, S., Bignelli, A. T., Claro, L. M., Siqueira, S. S., Nakao, L. S., & Pecoits‐Filho, R. (2010) · Nephron Clinical Practice · doi:10.1159/000318792 · Cited by 72
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Mukai, H., Ledesma, H. M. V., Qureshi, A. R., Lindholm, B., & Stenvinkel, P. (2018) · Seminars in Dialysis · doi:10.1111/sdi.12731 · Cited by 71
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Svensson, M. H. S., Schmidt, E. B., Jørgensen, K. A., & Christensen, J. H. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn180 · Cited by 71
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Rhee, C. M., Kim, S., Gillen, D. L., Oztan, T., Wang, J., Mehrotra, R., Kuttykrishnan, S., Nguyen, D. V., Brunelli, S. M., Kovesdy, C. P., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4311 · Cited by 67
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Samouilidou, E. C., Karpouza, A., Kostopoulos, V., Bakirtzi, T., Pantelias, K., Petras, D. I., Tzanatou-Exarchou, H., & Grapsa, E. J. (2011) · Renal Failure · doi:10.3109/0886022x.2011.641515 · Cited by 63
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Self-citationRivara, M. B., Yeung, C. K., Robinson‐Cohen, C., Phillips, B., RUZINSKI, J. T., Rock, D., Linke, L., Shen, D. D., Ikizler, T. A., & Himmelfarb, J. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.08.041 · Cited by 65
Self-citationLiu, J., Tian, J., Chaudhry, M. A., Maxwell, K., Yan, Y., Wang, X., Shah, P. T., Khawaja, A. A., Martin, R., Robinette, T. J., et al. (2016) · Scientific Reports · doi:10.1038/srep34592 · Cited by 63
Nakayama, M., Sato, T., Sato, H., Yamaguchi, Y., Obara, K., Kurihara, I., Sato, K., Hotta, O., Seino, J., Miyata, M., et al. (2010) · Clinical and Experimental Nephrology · doi:10.1007/s10157-010-0295-y · Cited by 62
Impairments of the biological properties of serum albumin in patients on haemodialysis
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Metadata
- Authors
- Himmelfarb, J., Stenvinkel, P., Ikizler, T. A., & Hakim, R. M.
- Affiliations
- Maine Medical Center (US)
- Corresponding author
- Himmelfarb, Jonathan
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 62
- Issue
- 5
- Pages
- 1524-1538
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W1996978408
- Cited by
- 1,179
- References
- 294
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 29 · 2023: 31 · 2022: 36 · 2021: 51 · 2020: 40 · 2019: 30 · 2018: 43 · 2017: 57 · 2016: 49 · 2015: 57 · 2014: 58 · 2013: 71 · 2012: 68
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- uremia, oxidative stress, cardiovascular disease, atherosclerosis, inflammation, malnutrition, dialysis, uremic solutes, beta2-microglobulin, homocysteine, cysteine, antioxidant therapy, vascular access catheters, cardiovascular mortality
- MeSH terms
- Cardiovascular Diseases, Humans, Uremia, Oxidative Stress
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