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Enhancement of wound healing by curcumin in animals
Abstract
Tissue repair and wound healing are complex processes that involve inflammation, granulation, and remodeling of the tissue. In this study, we evaluated the in vivo effects of curcumin (difeurloylmethane), a natural product obtained from the rhizomes of Curcuma longa on wound healing in rats and guinea pigs. We observed faster wound closure of punch wounds in curcumin‐treated animals in comparison with untreated controls. Biopsies of the wound showed reepithelialization of the epidermis and increased migration of various cells including myofibroblasts, fibroblasts, and macrophages in the wound bed. Multiple areas within the dermis showed extensive neovascularization, and Masson's Trichrome staining showed greater collagen deposition in curcumin‐treated wounds. Immunohistochemical localization of transforming growth factor‐β1 showed an increase in curcumin‐treated wounds as compared with untreated wounds. In situ hybridization and polymerase chain reaction analysis also showed an increase in the mRNA transcripts of transforming growth factor‐β1 and fibronectin in curcumin‐treated wounds. Because transforming growth factor‐β1 is known to enhance wound healing, it may be possible that transforming growth factor‐β1 plays an important role in the enhancement of wound healing by curcumin.
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Cited by
Multiple biological activities of curcumin: A short review
Maheshwari, R. K., Singh, A. K., Gaddipati, J., & Srimal, R. C. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.007 · Cited by 1,674
Self-citationPLGA based drug delivery systems: promising carriers for wound healing activity
Chereddy, K. K., Vandermeulen, G., & Préat, V. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12404 · Cited by 215
Metadata
- Authors
- Sidhu, G. S., Singh, A. K., Thaloor, D., Banaudha, K. K., Patnaik, G. K., Srimal, R. C., & Maheshwari, R. K.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 1998-03
- Volume
- 6
- Issue
- 2
- Pages
- 167-177
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2048620231
- Cited by
- 372
- References
- 0
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
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