PLGA based drug delivery systems: promising carriers for wound healing activity
Abstract
Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Current treatment options are limited and require repeated administrations which led to the development of new therapeutics to satisfy the unmet clinical needs. Many potent wound healing agents were discovered but most of them are fragile and/or sensitive to in vivo conditions. Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer approved by food and drug administration and European medicines agency as an excipient for parenteral administrations. It is a well-established drug delivery system in various medical applications. The aim of the current review is to elaborate the applications of PLGA based drug delivery systems carrying different wound healing agents and also present PLGA itself as a wound healing promoter. PLGA carriers encapsulating drugs such as antibiotics, anti-inflammatory drugs, proteins/peptides, and nucleic acids targeting various phases/signaling cycles of wound healing, are discussed with examples. The combined therapeutic effects of PLGA and a loaded drug on wound healing are also mentioned.
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PLGA approved by FDA is characterized by nontoxicity, good biocompatibility and can provide sustained protein release, which is important to elicit potent immune responses.
“PLGA approved by the Food and Drug Administration (FDA) is characterized by nontoxicity, good biocompatibility and can provide sustained protein release, which is important to elicit potent immune responses (Allahyari et al., 2016; Chereddy et al., 2016).”
From Protective efficacy of Toxoplasma gondii GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute Toxoplasma gondii infection in mice (2023) · cites this paper as Chereddy et al., 2016
PLGA has unique biocompatibility, tunable biodegradability, acceptable mechanical properties, and FDA approval for implantable devices.
“Poly (lactic acid-co-glycolic acid) (PLGA) has been employed for implantable devices based on their unique biocompatibility, tunable biodegradability, acceptable mechanical properties, and FDA approval [33].”
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“Poly (lactic acid-co-glycolic acid) (PLGA) has been employed for implantable devices based on their unique biocompatibility, tunable biodegradability, acceptable mechanical properties, and FDA approval [33].”
BackgroundSun, H.-C., Deng, P.-M., Fu, Y., Deng, J.-H., Xie, R.-H., Huang, J., Qi, M., & Shi, T.-Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1209755 · Cited by 27 · see citing works
- Authors
- Chereddy, K. K., Vandermeulen, G., & Préat, V.
- Affiliations
- UCLouvain (BE)
- Catholic University of Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials Brussels Belgium
- ORCID
- Vandermeulen, Gaëlle
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2016-03
- Volume
- 24
- Issue
- 2
- Pages
- 223-236
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W2229086138
- Cited by
- 215
- References
- 100
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 30 · 2023: 32 · 2022: 36 · 2021: 20 · 2020: 23 · 2019: 10 · 2018: 14 · 2017: 11
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- European Commission and Marie Curie Actions (PITN-GA-2011-289454)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- PLGA, poly(lactic-co-glycolic acid), drug delivery systems, wound healing, biodegradable polymers, wound healing agents, antibiotics, anti-inflammatory agents, protein and peptide delivery, nucleic acid delivery
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Anti-Inflammatory Agents, Non-Steroidal, Curcumin, Dose-Response Relationship, Drug, Drug Carriers, Humans, Polyglycolic Acid, Wound Healing, Wounds and Injuries, Drug Delivery Systems, Neovascularization, Physiologic, Lactic Acid, Regenerative Medicine, Nanoparticles
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