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A Bilayered Living Skin Construct (Apligraf) Accelerates Complete Closure of Hard‐to‐Heal Venous Ulcers
Abstract
The efficacy of a bilayered, living skin construct (APLIGRAF®[Graftskin]) was evaluated in patients (n = 120) with hard‐ to‐heal venous leg ulcers of greater than 1 year's duration. The study was prospective, randomized, and controlled. Patients received Graftskin plus compression therapy, or standard compression therapy (active control). Patients were evaluated for frequency and time to complete (100%) wound closure. Treatment with Graftskin was significantly more effective than active control in the percentage of patients healed by 6 months (47% vs. 19%; p < 0.005) and the median time to complete wound closure (p < 0.005). Analysis with multivariate regression methods, adjusting for factors generally thought to influence wound healing (duration, baseline area, depth, location, fibrinous wound bed, and infection), showed that patients treated with Graftskin were twice as likely to achieve complete wound closure by 6 months (p < 0.005), and over 60% more effective in achieving wound closure than active control (p < 0.01). These data indicate that Graftskin is an effective treatment for venous ulcers of greater than 1 year's duration.
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“Apligraf exhibited a broader range of healing (49–181 days), with one study demonstrating the longest healing time [33].”
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Cited by
Broughton, G., Janis, J. E., & Attinger, C. E. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000222562.60260.f9 · Cited by 917
Falanga, V., Iwamoto, S., Chartier, M., Yufit, T., Butmarc, J., Kouttab, N., Shrayer, D., & Carson, P. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0278 · Cited by 783
Self-citationWound healing and treating wounds
Morton, L. M., & Phillips, T. J. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.08.068 · Cited by 475
Collagen—emerging collagen based therapies hit the patient
Abou Neel, E. A., Bozec, L., Knowles, J. C., Syed, O., Mudera, V., Day, R., & Hyun, J. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.010 · Cited by 296
Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options
Debels, H., Hamdi, M., Abberton, K., & Morrison, W. (2015) · Plastic and Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000000219 · Cited by 227
Metadata
- Authors
- Falanga, V., & Sabolinski, M.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 1999-09
- Volume
- 7
- Issue
- 4
- Pages
- 201-207
- ISSN
- 1067-1927
- 1524-475X
- Cited by
- 326
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: A Bilayered Living Skin Construct (Apligraf) Accelerates Complete Closure of Hard‐to‐Heal Venous Ulcers. https://app.cochat.ai/papers/10.1046/j.1524-475x.1999.00201.x
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- Falanga, V., & Sabolinski, M. (1999). A Bilayered Living Skin Construct (Apligraf) Accelerates Complete Closure of Hard‐to‐Heal Venous Ulcers. Wound Repair and Regeneration. https://doi.org/10.1046/j.1524-475x.1999.00201.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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