The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Recombinant human platelet‐derived growth factor‐BB (becaplermin) for healing chronic lower extremity diabetic ulcers: an open‐label clinical evaluation of efficacy
Abstract
Topically applied recombinant human platelet‐derived growth factor‐BB (becaplermin) is a new pharmacologically active therapy for chronic, neuropathic, lower extremity diabetic ulcers. In previous studies, becaplermin gel was administered once daily but dressings were changed twice daily. In the present study of 134 patients with diabetes mellitus and full thickness lower extremity ulcers, dressings were changed only once per day, simplifying the treatment regimen. Efficacy criteria included the percentage of patients achieving complete healing within the 20‐week treatment period, the time to achieve complete healing, the rate of ulcer recurrence during the 6‐month period following healing, and treatment compliance. Complete healing of ulcers was achieved in 57.5% of patients, with a mean time to closure of 63 days and a recurrence rate of 21% at 6 months. Of the potential factors affecting ulcer healing, only drug compliance (p < 0.001), dressing compliance (p < 0.01), the presence of infection (p < 0.01), baseline ulcer area (p < 0.05), and baseline total wound evaluation score (p < 0.05) were significantly associated with healing. Results of this study further confirm the efficacy and safety of becaplermin gel for the treatment of lower extremity diabetic ulcers.
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Smiell, J. M., Wieman, T. J., Steed, D. L., Perry, B. H., Sampson, A. R., & Schwab, B. H. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00335.x · Cited by 454
Self-citationGrotendorst, G. R., Martin, G. R., Pencev, D., Sodek, J., & Harvey, A. K. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112243 · Cited by 275
Cited by
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Activity Patterns of Patients With Diabetic Foot Ulceration
Armstrong, D. G., Lavery, L. A., Kimbriel, H. R., Nixon, B. P., & Boulton, A. J. M. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2595 · Cited by 306
Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., et al. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8491-x · Cited by 304
Diagnosis and Treatment of Diabetic Foot Infections
Lipsky, B. A., Berendt, A. R., Deery, H. G., Embil, J. M., Joseph, W. S., Karchmer, A. W., LeFrock, J. L., Lew, D. P., Mader, J. T., Norden, C., et al. (2006) · Plastic and Reconstructive Surgery · doi:10.1097/01.prs.0000222737.09322.77 · Cited by 221
Self-citationKwon, H., Kim, M., Seo, Y., Moon, Y. S., Lee, H. J., Lee, K., & Lee, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.034 · Cited by 208
Metadata
- Authors
- Embil, J. M., Papp, K., Sibbald, G., Tousignant, J., Smiell, J. M., Wong, B., Lau, C. Y., & THE CANADIAN BECAPLERMIN STUDY GROUP
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2000-06
- Volume
- 8
- Issue
- 3
- Pages
- 162-168
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1993842439
- Cited by
- 161
- References
- 2
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Embil, J. M., Papp, K., Sibbald, G., Tousignant, J., Smiell, J. M., Wong, B., Lau, C. Y., & THE CANADIAN BECAPLERMIN STUDY GROUP. (2000). Recombinant human platelet‐derived growth factor‐BB (becaplermin) for healing chronic lower extremity diabetic ulcers: an open‐label clinical evaluation of efficacy. Wound Repair and Regeneration. https://doi.org/10.1046/j.1524-475x.2000.00162.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
