Cited by 304Advanced Glycation End Products researchGalectins and Cancer BiologyBiomarkers in Disease Mechanisms

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

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Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F. +3 more·2002·Cellular and Molecular Life Sciences (CMLS)

Abstract

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

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Crossref · 10.1007/s00018-002-8491-x

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56 of 56 references verified0 citation errors · 0 not checkable

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  • RAGE detects advanced glycation end-products (AGEs) that arise from non-enzymatic glycation and oxidation of proteins and lipids.

    “It detects advanced glycation end-products (AGes) that arise from non-enzymatic glycation and oxidation of proteins and lipids.”

    From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [92]

  • Blockade of RAGE by a soluble competitive inhibitor suppressed diabetes-associated atherosclerosis in mouse models.

    “Furthermore, blockade of RAGe by using a soluble competitive inhibitor suppressed diabetes-associated atherosclerosis in mouse models92.”

    From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [92]

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Authors
Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., & Schmidt, A. M.
Affiliations
Columbia University (US)
Venue
Cellular and Molecular Life Sciences (CMLS)
Published
2002-07-01
Volume
59
Issue
7
Pages
1117-1128
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W1979731419
Cited by
304
References
56
Citations by year
2026: 1 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 15 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 20 · 2015: 14 · 2014: 13 · 2013: 14 · 2012: 20
FWCI
9.38
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Keywords
receptor for advanced glycation end products, RAGE, immunoglobulin superfamily, advanced glycation end products, amyloid-beta, β-sheet fibrils, S100/calgranulins, amphoterin, diabetes mellitus, inflammation, neurodegenerative diseases, tumors, homeostasis, chronic disease
MeSH terms
Receptor for Advanced Glycation End Products, Alzheimer Disease, Amyloidosis, Animals, Arteriosclerosis, Cell Movement, Chronic Disease, Diabetic Angiopathies, Homeostasis, Humans, Immunoglobulins, Inflammation, Neoplasms, Receptors, Immunologic, Signal Transduction, Mice

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