RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease
Open accessAbstract
Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.
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RAGE detects advanced glycation end-products (AGEs) that arise from non-enzymatic glycation and oxidation of proteins and lipids.
“It detects advanced glycation end-products (AGes) that arise from non-enzymatic glycation and oxidation of proteins and lipids.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [92]
Blockade of RAGE by a soluble competitive inhibitor suppressed diabetes-associated atherosclerosis in mouse models.
“Furthermore, blockade of RAGe by using a soluble competitive inhibitor suppressed diabetes-associated atherosclerosis in mouse models92.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [92]
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- Authors
- Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., & Schmidt, A. M.
- Affiliations
- Columbia University (US)
- Venue
- Cellular and Molecular Life Sciences (CMLS)
- Published
- 2002-07-01
- Volume
- 59
- Issue
- 7
- Pages
- 1117-1128
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11337527
- OpenAlex
- W1979731419
- Cited by
- 304
- References
- 56
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 15 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 20 · 2015: 14 · 2014: 13 · 2013: 14 · 2012: 20
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- receptor for advanced glycation end products, RAGE, immunoglobulin superfamily, advanced glycation end products, amyloid-beta, β-sheet fibrils, S100/calgranulins, amphoterin, diabetes mellitus, inflammation, neurodegenerative diseases, tumors, homeostasis, chronic disease
- MeSH terms
- Receptor for Advanced Glycation End Products, Alzheimer Disease, Amyloidosis, Animals, Arteriosclerosis, Cell Movement, Chronic Disease, Diabetic Angiopathies, Homeostasis, Humans, Immunoglobulins, Inflammation, Neoplasms, Receptors, Immunologic, Signal Transduction, Mice
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