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Cited by 356

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Interpreting the Mechanisms of Continuous Renal Replacement Therapy in Sepsis: The Peak Concentration Hypothesis

Ronco, Claudio, Tetta, Ciro, Mariano, Filippo, Wratten, Mary Lou, Bonello, Monica, Bordoni, Valeria, Cardona, Ximena, Inguaggiato, Paola, Pilotto, Lidia, D’Intini, Vince, Bellomo, Rinaldo·2003·Artificial Organs
DOI 10.1046/j.1525-1594.2003.07289.x
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Abstract

Abstract: Severe sepsis and septic shock are the primary causes of multiple organ dysfunction syndrome (MODS), which is the most frequent cause of death in intensive care unit patients. Many water‐soluble mediators with pro‐ and anti‐inflammatory action such as TNF, IL‐6, IL‐8, and IL‐10 play a strategic role in septic syndrome. In intensive care medicine, blocking any one mediator has not led to a measurable outcome improvement in patients with sepsis. CRRT is a continuously acting therapy, which removes in a nonselective way pro‐ and anti‐inflammatory mediators; “the peak concentration hypothesis” is the concept of cutting peaks of soluble mediators through continuous hemofiltration. Furthermore, there is evidence of increased efficacy of high‐volume hemofiltration compared to conventional CVVH, and other blood purification techniques that utilize large‐pore membranes or sorbent plasmafiltration are conceptually interesting.

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Metadata

Authors
Ronco, C., Tetta, C., Mariano, F., Wratten, M. L., Bonello, M., Bordoni, V., Cardona, X., Inguaggiato, P., Pilotto, L., D’Intini, V., & Bellomo, R.
Venue
Artificial Organs
Publisher
Wiley
Published
2003-08-28
Volume
27
Issue
9
Pages
792-801
ISSN
  • 0160-564X (ISSN-L)
  • 1525-1594
DOI
10.1046/j.1525-1594.2003.07289.x
OpenAlex
W2096458783
Cited by
356
References
61
FWCI
6.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Interpreting the Mechanisms of Continuous Renal Replacement Therapy in Sepsis: The Peak Concentration Hypothesis. https://app.cochat.ai/papers/10.1046/j.1525-1594.2003.07289.x
The paper
Ronco, C., Tetta, C., Mariano, F., Wratten, M. L., Bonello, M., Bordoni, V., Cardona, X., Inguaggiato, P., Pilotto, L., D’Intini, V., & Bellomo, R. (2003). Interpreting the Mechanisms of Continuous Renal Replacement Therapy in Sepsis: The Peak Concentration Hypothesis. Artificial Organs. https://doi.org/10.1046/j.1525-1594.2003.07289.x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.