Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,102

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

Suffredini, Anthony F., Fromm, Robert E., Parker, Margaret M., Brenner, Matthew, Kovacs, Joseph A., Wesley, Robert A., Parrillo, Joseph E.·1989·New England Journal of Medicine
DOI 10.1056/nejm198908033210503
Open this paper in CoChat — free account

Abstract

Marked abnormalities in cardiovascular function accompany septic shock, and bacterial endotoxin is believed to be one of the principal mediators of these abnormalities. To evaluate the cardiovascular effects of endotoxemia in humans, we measured hemodynamic variables in nine normal subjects given an intravenous bolus dose of endotoxin (Escherichia coli, 4 ng per kilogram of body weight) and in six normal subjects given a bolus dose of saline, before and three hours after administration. All the subjects then underwent volume loading with normal saline (mean, 2217 ml) during the fourth and fifth hours after administration of the bolus, and the measurements were repeated. Three hours after the administration of endotoxin and before volume loading, the cardiac index had increased by 53 percent and the heart rate by 36 percent (both changes were significant; P less than or equal to 0.008), and the systemic vascular-resistance index had decreased by 46 percent (P = 0.004). After volume loading (five hours after the administration of endotoxin), the left ventricular ejection fraction decreased by 1 percent of the base-line value in the subjects given endotoxin, but increased by 14 percent in the controls (P = 0.008). The left ventricular end-diastolic and end-systolic volume indexes increased by 18 percent (P = 0.07) and 24 percent (P = 0.042), respectively. Left ventricular performance, as measured by the ratio of the peak systolic pressure to the end-systolic volume index, was depressed (a decrease of 0.90 in the subjects given endotoxin vs. an increase of 0.76 in the controls; P = 0.024). We conclude that the administration of endotoxin to normal subjects causes a depression of left ventricular function that is independent of changes in left ventricular volume or vascular resistance. The changes in function are similar to those observed in septic shock and suggest that endotoxin is a major mediator of the cardiovascular dysfunction in this condition.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejm198908033210503

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 40

  1. Kreger, 1980, Am J Med, 68, 344, 10.1016/0002-9343(80)90102-3 · DOI · Paper page
  2. Bone, 1987, N Engl J Med, 317, 653, 10.1056/NEJM198709103171101 · DOI · Paper page
  3. The Veterans Administration Systemic Sepsis Cooperative Study Group, 1987, N Engl J Med, 317, 659, 10.1056/NEJM198709103171102 · DOI · Paper page
  4. Parker, 1987, Crit Care Med, 15, 923, 10.1097/00003246-198710000-00006 · DOI · Paper page
  5. van Deventer, 1988, Lancet, 1, 605, 10.1016/S0140-6736(88)91412-2 · DOI · Paper page
  6. Ziegler, 1982, N Engl J Med, 307, 1225, 10.1056/NEJM198211113072001 · DOI · Paper page
  7. Baumgartner, 1985, Lancet, 2, 59, 10.1016/S0140-6736(85)90176-X · DOI · Paper page
  8. Beutler, 1987, N Engl J Med, 316, 379, 10.1056/NEJM198702123160705 · DOI · Paper page
  9. Rackow, 1987, Circ Shock, 22, 11
  10. Parker, 1984, Ann Intern Med, 100, 483, 10.7326/0003-4819-100-4-483 · DOI · Paper page
  11. Ellrodt, 1985, Am Heart J, 110, 402, 10.1016/0002-8703(85)90163-2 · DOI · Paper page
  12. Parker, 1989, J Crit Care, 4, 19, 10.1016/0883-9441(89)90087-7 · DOI
  13. Wichterman, 1980, J Surg Res, 29, 189, 10.1016/0022-4804(80)90037-2 · DOI · Paper page
  14. Gilbert, 1960, Physiol Rev, 40, 245, 10.1152/physrev.1960.40.2.245 · DOI · Paper page
  15. Bradley, 1945, J Clin Invest, 24, 749, 10.1172/JCI101660 · DOI
  16. Moser, 1963, J Clin Invest, 42, 626, 10.1172/JCI104753 · DOI
  17. Hochstein, 1983, J Biol Stand, 11, 251, 10.1016/S0092-1157(83)80013-4 · DOI
  18. Elin, 1981, J Infect Dis, 144, 329, 10.1093/infdis/144.4.329 · DOI
  19. Bonow, 1982, Circulation, 66, 1159, 10.1161/01.CIR.66.6.1159 · doi:10.1161/01.cir.66.6.1159
  20. Espevik, 1986, J Immunol Methods, 95, 99, 10.1016/0022-1759(86)90322-4 · DOI · Paper page
  21. Waage, 1987, Lancet, 1, 355, 10.1016/S0140-6736(87)91728-4 · DOI · Paper page
  22. Mosmann, 1983, J Immunol Methods, 65, 55, 10.1016/0022-1759(83)90303-4 · DOI · Paper page
  23. Hollander M, Wolfe DA. Nonparametric statistical methods. New York: John Wiley, 1973:27–33, 67–74.
  24. van Zwet, 1967, Ann Math Stat, 38, 659, 10.1214/aoms/1177698861 · DOI
  25. Braunwald E, ed. Heart disease: a textbook of cardiovascular medicine. 3rd ed. Vol. 1. Philadelphia: W.B. Saunders, 1988:449–70.
  26. Carabello, 1984, Circulation, 69, 1058, 10.1161/01.CIR.69.5.1058 · DOI
  27. Ognibene, 1988, Chest, 93, 903, 10.1378/chest.93.5.903 · DOI · Paper page
  28. Natanson, 1986, J Clin Invest, 78, 259, 10.1172/JCI112559 · DOI · Paper page
  29. Calvin, 1981, Crit Care Med, 9, 437, 10.1097/00003246-198106000-00001 · DOI
  30. Cunnion, 1986, Circulation, 73, 637, 10.1161/01.CIR.73.4.637 · DOI · Paper page
  31. Dhainaut, 1987, Circulation, 75, 533, 10.1161/01.CIR.75.3.533 · DOI · Paper page
  32. Lang, 1988, Ann Intern Med, 108, 524, 10.7326/0003-4819-108-4-524 · DOI · Paper page
  33. Cho, 1972, Proc Soc Exp Biol Med, 141, 705, 10.3181/00379727-141-36856 · doi:10.3181/00379727-141-36856
  34. Brenner, 1987, Clin Res, 35, 785A
  35. Parrillo, 1985, J Clin Invest, 76, 1539, 10.1172/JCI112135 · DOI · Paper page
  36. Reilly, 1989, Chest, 95, 1072, 10.1378/chest.95.5.1072 · DOI · Paper page
  37. Natanson, 1989, J Exp Med, 169, 823, 10.1084/jem.169.3.823 · DOI · Paper page
  38. Moore, 1966, Ann Thorac Surg, 2, 446, 10.1016/S0003-4975(10)66601-5 · doi:10.1016/s0003-4975(10)66601-5
  39. Cooper, 1962, J Thorac Cardiovasc Surg, 44, 667, 10.1016/S0022-5223(19)32931-9 · doi:10.1016/s0022-5223(19)32931-9
  40. Tonnesen, 1987, J Appl Physiol, 62, 1596, 10.1152/jappl.1987.62.4.1596 · doi:10.1152/jappl.1987.62.4.1596

Cited by

See all 1,102

Metadata

Authors
Suffredini, A. F., Fromm, R. E., Parker, M. M., Brenner, M., Kovacs, J. A., Wesley, R. A., & Parrillo, J. E.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1989-08-03
Volume
321
Issue
5
Pages
280-287
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198908033210503
OpenAlex
W2319070317
Cited by
1,102
References
1
FWCI
29.20
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The Cardiovascular Response of Normal Humans to the Administration of Endotoxin. https://app.cochat.ai/papers/10.1056/nejm198908033210503
The paper
Suffredini, A. F., Fromm, R. E., Parker, M. M., Brenner, M., Kovacs, J. A., Wesley, R. A., & Parrillo, J. E. (1989). The Cardiovascular Response of Normal Humans to the Administration of Endotoxin. New England Journal of Medicine. https://doi.org/10.1056/nejm198908033210503

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.