The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Heart Rate and Heart Rate Variability Changes in the Intracarotid Sodium Amobarbital Test
Open accessAbstract
PURPOSE: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used. METHODS: The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated. RESULTS: Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA. CONCLUSIONS: The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The stress response is mediated by subcortical areas in the brain, i.e. the so called limbic structures, including the amygdala, and it is normally under continuous ('tonic') inhibition by the prefrontal cortex (PFC; Ahern et al., 2001), more specifically by the ventromedial PFC (vmPFC; Motzkin et al., 2015).”
From Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity (2017) · cites this paper as Ahern et al., 2001
In the citing paper
“the stress response is a default response”
From Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity (2017) · cites this paper as Ahern et al., 2001
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
A model of neurovisceral integration in emotion regulation and dysregulation
Thayer, J. F., & Lane, R. D. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00338-4 · Cited by 3,092
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance
Wada, J., & Rasmussen, T. (1960) · Journal of neurosurgery · doi:10.3171/jns.1960.17.2.0266 · Cited by 1,576
The Central Autonomic Network: Functional Organization, Dysfunction, and Perspective
BENARROCH, E. E. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62272-1 · Cited by 1,534
Katirji, M. B. (1993) · Neurology · doi:10.1212/wnl.43.11.2429 · Cited by 590
Gender- and age-related differences in heart rate dynamics: Are women more complex than men?
Ryan, S. M., Goldberger, A. L., Pincus, S. M., Mietus, J. E., & Lipsitz, L. A. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90177-5 · Cited by 454
Hypoarousal in patients with the neglect syndrome and emotional indifference
Heilman, K. M., Schwartz, H. D., & Watson, R. T. (1978) · Neurology · doi:10.1212/wnl.28.3.229 · Cited by 411
Cortical Modulation of theCardiovascular System
Verberne, A. J. M., & Owens, N. C. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00056-7 · Cited by 351
Parental investment theory and gender differences in the evolution of inhibition mechanisms.
Bjorklund, D. F., & Kipp, K. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.120.2.163 · Cited by 348
ELECTROCARDIOGRAPHIC ACCOMPANIMENTS OF TEMPORAL LOBE EPILEPTIC SEIZURES
Blumhardt, L. D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91328-0 · Cited by 285
Unilateral cerebral inactivation produces differential left/right heart rate responses
ZAMRINI, E. Y., Meador, K. J., Loring, D. W., Nichols, F. T., Lee, G. P., Figueroa, R. E., & Thompson, W. O. (1990) · Neurology · doi:10.1212/wnl.40.9.1408 · Cited by 252
Frontal-subcortical circuits: the anatomic basis of executive, social and motivated behaviors
Masterman, D. L., & Cummings, J. L. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100203 · Cited by 244
Sudden Unexpected Death Associated with Seizures: Analysis of 66 Cases
Leestma, J. E., Kalelkar, M. B., Teas, S. S., Jay, G. W., & Hughes, J. R. (1984) · Epilepsia · doi:10.1111/j.1528-1157.1984.tb04159.x · Cited by 222
Roberts, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.252 · Cited by 213
Cerebral Hemispheric Lateralization in Cardiac Autonomic Control
Yoon, B.-W., Morillo, C. A., Cechetto, D. F., & Hachinski, V. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550180055012 · Cited by 188
Reduced Heart Rate Variability After Right-Sided Stroke
Naver, H., Blomstrand, C., & Wallin, B. G. (1996) · Stroke · doi:10.1161/01.str.27.2.247 · Cited by 175
Asymmetry of Sympathetic Consequences of Experimental Stroke
Hachinski, V. C., Oppenheimer, S. M., Wilson, J. X., Guiraudon, C., & Cechetto, D. F. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530310039010 · Cited by 156
Massetani, R., Strata, G., Galli, R., Gori, S., Gneri, C., Limbruno, U., Santo, D. D., Mariani, M., & Murri, L. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01129.x · Cited by 144
Supraventricular tachycardia in patients with right hemisphere strokes.
Lane, R. D., Wallace, J. D., Petrosky, P. P., SCHWARTZ, G. E. R., & Gradman, A. H. (1992) · Stroke · doi:10.1161/01.str.23.3.362 · Cited by 134
Accentuated antagonism in the control of human heart rate
Uijtdehaage, S. H. J., & Thayer, J. F. (2000) · Clinical Autonomic Research · doi:10.1007/bf02278013 · Cited by 129
Amobarbital Effects and Lateralized Brain Function: The Wada Test
Loring, D. W. (1991) · Medical Entomology and Zoology · Cited by 124
Forebrain parasympathetic control of heart activity: retrograde transneuronal viral labeling in rats
Horst, G. J. T., & Postema, F. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.6.h2926 · Cited by 115
Verberne, A. J. M. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.4.r713 · Cited by 109
Fitness and Gender-Related Differences in Heart Period Variability
Rossy, L. A., & Thayer, J. F. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199811000-00022 · Cited by 106
Amobarbital Effects and Lateralized Brain Function
Loring, D. W., Meador, K. J., Lee, G. P., & King, D. W. (1992) · Springer eBooks · doi:10.1007/978-1-4612-2874-5 · Cited by 106
Lack of heart rate changes during an attention‐demanding task after right hemisphere lesions
Yokoyama, K., Jennings, R., Ackles, P. K., Hood, P., & Boller, F. (1987) · Neurology · doi:10.1212/wnl.37.4.624 · Cited by 93
Neural mechanisms involved in cardiovascular control during affective behaviour
Spyer, K. M. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90111-2 · Cited by 89
Neural control of cardiac function.
Levy, M. N. (1997) · PubMed · Cited by 87
Desmond, M. J. (1996) · Postgraduate Medical Journal · doi:10.1136/pgmj.72.847.319 · Cited by 80
Perseverative Thinking and Health: Neurovisceral Concomitants
Thayer, J. F., & Lane, R. D. (2002) · Psychology and Health · doi:10.1080/08870440290025867 · Cited by 78
Al-Maskati, H. A., & Zbrożyna, A. W. (1989) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(89)90084-2 · Cited by 76
Kennebäck, G., Ericson, M. O., Tomson, T., & Bergfeldt, L. (1997) · Seizure · doi:10.1016/s1059-1311(97)80036-2 · Cited by 74
Horst, G. J. T. (1999) · European Journal of Morphology · doi:10.1076/ejom.37.4.257.4722 · Cited by 65
Postictal heart rate oscillations in partial epilepsy
Al-Aweel, I. C., Krishnamurthy, K. B., Hausdorff, J. M., Mietus, J. E., Ives, J. R., Blum, A. S., Schomer, D. L., & Goldberger, A. L. (1999) · Neurology · doi:10.1212/wnl.53.7.1590 · Cited by 65
Levy, M. N., Yang, T., & Wallick, D. W. (1993) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1993.tb01222.x · Cited by 61
Contralateral EEG Slowing and Amobarbital Distribution in Wada Test: An Intracarotid SPECT Study
Hong, S. B., Kim, K., Seo, D. W., Kim, S. E., Na, D. G., & Byun, H. S. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb00141.x · Cited by 44
Quantitative analysis of the EEG in the intracarotid amobarbital procedure. I. Amplitude analysis
Ahern, G. L., Labiner, D. M., Hutzler, R., Osburn, C. M., Talwar, D., Herring, A. M., Tackenberg, J. N., Weinand, M. E., & Oommen, K. J. (1994) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)90015-9 · Cited by 24
Heart rate does not decrease after right hemispheric amobarbital injection
Jokeit, H., Noerpel, I., Herbord, E., & Ebner, A. (2000) · Neurology · doi:10.1212/wnl.54.12.2347 · Cited by 12
Affective self-report during the intracarotid sodium amobarbital test: Group differences
Ahern, G. L., Herring, A. M., Labiner, D. M., Weinand, M. E., & Hutzler, R. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700666031 · Cited by 8
Emotions and Heart-Activity Control
Horst, G. J. T. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-713-0_2 · Cited by 5
Research works printed but not linked: 4
- Rosen AD, 1982, Hemispheric asymmetry in the control of heart rate., Soc Neurosci Abstr, 8, 917
- Mehta C, 1995, StatXact 3 user manual
- Preston E, 1995, Physiological correlates of vagus nerve innervation in lower vertebrates., Am J Physiol, 268, 1249
- 10.1037//0033-2909.120.2.163 · DOI
Cited by
Sorted by citations
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040
Thayer, J. F., Hansen, A. L., Saus-Rose, E., & Johnsen, B. H. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9101-z · Cited by 1,872
The role of vagal function in the risk for cardiovascular disease and mortality
Thayer, J. F., & Lane, R. D. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.013 · Cited by 1,033
Self-citationHeart rate variability as a transdiagnostic biomarker of psychopathology
Beauchaine, T. P., & Thayer, J. F. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.08.004 · Cited by 870
Neural correlates of heart rate variability during emotion
Lane, R. D., Kateri Mcrae, A., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.056 · Cited by 687
Metadata
- Authors
- Ahern, G. L., Sollers, J. J., Lane, R. D., Labiner, D. M., Herring, A. M., Weinand, M. E., Hutzler, R., & Thayer, J. F.
- Affiliations
- University of Arizona (US)
- National Institute on Aging (US)
- Corresponding author
- Ahern, Geoffrey L.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2001-07-07
- Volume
- 42
- Issue
- 7
- Pages
- 912-921
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1988655270
- Cited by
- 195
- References
- 43
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 17
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- heart rate, heart rate variability, hemispheric lateralization, parasympathetic activity, electrocardiogram
- MeSH terms
- Adolescent, Adult, Aged, Amobarbital, Analysis of Variance, Autonomic Nervous System, Brain, Carotid Artery, Internal, Electrocardiography, Epilepsy, Female, Heart, Heart Rate, Humans, Infusions, Intra-Arterial, Functional Laterality, Male, Middle Aged, Vagus Nerve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
