The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Antiepileptogenesis and Seizure Prevention Trials with Antiepileptic Drugs: Meta‐Analysis of Controlled Trials
Open accessAbstract
Summary: Purpose: To synthesize evidence concerning the effect of antiepileptic drugs (AEDs) for seizure prevention and to contrast their effectiveness for provoked versus unprovoked seizures. Methods: Medline, Embase, and The Cochrane Clinical Trials Register were the primary sources of trials, but all trials found were included. Minimal requirements: seizure‐prevention outcome given as fraction of cases; AED or control assigned by random or quasi‐random mechanism. Single abstracter. Aggregate relative risk and heterogeneity evaluated using Mantel–Haenszel analyses; random effects model used if heterogeneity was significant. Results: Forty‐seven trials evaluated seven drugs or combinations for preventing seizures associated with fever, alcohol, malaria, perinatal asphyxia, contrast media, tumors, craniotomy, and traumatic brain injury. Effective: Phenobarbital for recurrence of febrile seizures [relative risk (RR), 0.51; 95% confidence interval (CI), 0.32–0.82) and cerebral malaria (RR, 0.36; CI, 0.23–0.56). Diazepam for contrast media–associated seizures (RR, 0.10; CI, 0.01–0.79). Phenytoin for provoked seizures after craniotomy or traumatic brain injury (craniotomy: RR, 0.42; CI, 0.25–0.71; TBI: RR, 0.33; CI, 0.19–0.59). Carbamazepine for provoked seizures after traumatic brain injury (RR, 0.39; CI, 0.17–0.92). Lorazepam for alcohol‐related seizures (RR, 0.12; CI, 0.04–0.40). More than 25% reduction ruled out valproate for unprovoked seizures after traumatic brain injury (RR, 1.28; CI, 0.76–2.16), and carbamazepine for unprovoked seizures after craniotomy (RR, 1.30; CI, 0.75–2.25). Conclusions: Effective or promising results predominate for provoked (acute, symptomatic) seizures. For unprovoked (epileptic) seizures, no drug has been shown to be effective, and some have had a clinically important effect ruled out.
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Cites
A population-based study of seizures after traumatic brain injuries
Annegers, J. F., Hauser, W. A., Coan, S. P., & Rocca, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801013380104 · Cited by 1,090
A Randomized, Double-Blind Study of Phenytoin for the Prevention of Post-Traumatic Seizures
Temkin, N. R., Dikmen, S. S., Wilensky, A. J., Keihm, J., Chabal, S., & Winn, H. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230801 · Cited by 994
Self-citationGlantz, M. J., Cole, B. F., Forsyth, P. A., Recht, L. D., Wen, P. Y., Chamberlain, M. C., Grossman, S. A., & Cairncross, J. G. (2000) · Neurology · doi:10.1212/wnl.54.10.1886 · Cited by 858
Guidelines for the Management of Severe Head Injury: What we Know and What we Think we Know
Chesnut, R. M. (1997) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199705001-00004 · Cited by 798
Guidelines for the management of severe head injury
BULLOCK, R., CHESNUT, R. M., CLIFTON, G., GHAJAR, J., MARION, D. W., NARAYAN, R. K., NEWELL, D. W., PITTS, L. H., ROSNER, M. J., & WILBERGER, J. W. (1996) · European Journal of Emergency Medicine · doi:10.1097/00063110-199606000-00010 · Cited by 684
Phenobarbital for Febrile Seizures — Effects on Intelligence and on Seizure Recurrence
Farwell, J. R., Lee, Y. J., Hirtz, D. G., Sulzbacher, S. I., Ellenberg, J. H., & Nelson, K. B. (1990) · New England Journal of Medicine · doi:10.1056/nejm199002083220604 · Cited by 561
Seizures after head trauma: A population study
Annegers, J. F., Grabow, J. D., Groover, R. V., Laws, E. R., Elveback, L. R., & Kurland, L. T. (1980) · Neurology · doi:10.1212/wnl.30.7.683 · Cited by 550
Salazar, A. M., Jabbari, B., Vance, S. C., Grafman, J., Amin, D., & Dillon, J. D. (1985) · Neurology · doi:10.1212/wnl.35.10.1406 · Cited by 470
Valproate therapy for prevention of posttraumatic seizures: a randomized trial
Temkin, N. R., Dikmen, S. S., Anderson, G. D., Wilensky, A. J., Holmes, M. D., Cohen, W., Newell, D. W., Nelson, P., Awan, A., & Winn, H. R. (1999) · Journal of Neurosurgery · doi:10.3171/jns.1999.91.4.0593 · Cited by 360
Self-citationNew visions in the pharmacology of anticonvulsion
Löscher, W. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01514-8 · Cited by 269
Cited by
Guerrini, R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68182-8 · Cited by 848
Marson, A., Jacoby, A., Johnson, A., Kim, L., Gamble, C., & Chadwick, D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66694-9 · Cited by 438
Christensen, J., Pedersen, M. G., Pedersen, C. B., Sidenius, P., Olsen, J., & Vestergaard, M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60214-2 · Cited by 379
Gorter, J. A., van Vliet, E. A., Aronica, E., Breit, T., Rauwerda, H., Lopes da Silva, F. H., & Wadman, W. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-06.2006 · Cited by 316
Huang, Y., Doherty, J. J., & Dingledine, R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08422.2002 · Cited by 259
Metadata
- Authors
- Temkin, N. R.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2001-04-20
- Volume
- 42
- Issue
- 4
- Pages
- 515-524
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2091406481
- Cited by
- 448
- References
- 50
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
