Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study

Willoughby, John O.; Pope, Kenneth J.; Eaton, Vaughn

doi:10.1046/j.1528-1157.2003.58102.x-i1

Cited by 80Epilepsy research and treatmentSmoking Behavior and CessationVagus Nerve Stimulation Research

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Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study

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Willoughby, John O., Pope, Kenneth J., Eaton, Vaughn·2003·Epilepsia

DOI 10.1046/j.1528-1157.2003.58102.x-i1

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Abstract

Summary: Purpose: To test nicotine patch treatment for a patient with a defined mutation for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) whose seizures were refractory to standard antiepileptic therapy. Methods: Open and double‐blind trials of nicotine patches in an “n‐of‐one” study. The double‐blind trial comprised periods during which either placebo or nicotine patches were each used for three periods of 2 weeks, randomized in a double‐blind manner. Results: In an open study, nicotine patches reduced seizures from 1.65 ± 2.36 to 0.01 ± 0.0 seizures per day (p < 0.0001). In a double‐blinded placebo‐controlled phase, the average frequency of seizures on nicotine versus placebo was 0 ± 0 versus 0.56 ± 1.14 seizures per day (p < 0.0001). Conclusions: Nicotine patches may be of benefit to some individuals with ADNFLE.

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ADNFLE has at least six missense alleles in the α4 or β2 subunits.
“autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), which has at least six missense alleles in the α4 or β2 subunits (27–29).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [28]

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A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy
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Nicotine patches — Do they influence seizure number, stay durations or seizure rate during video EEG telemetry?
Parikh, M. S., Haltiner, A. M., de Menezes, M. S., Caylor, L. M., Sepkuty, J. P., Simon, E. A., Schoenfeld, J. L., & Doherty, M. J. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.12.007 · Cited by 5
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Nicotine as an antiepileptic agent in ADNFLE: an\n N-of-one study
Pope, K. J., Willoughby, J. O., & Eaton, V. (2003) · Flinders Academic Commons (Flinders University)
Self-citation
Resolution of epileptic encephalopathy following treatment with transdermal nicotine
Zerem, A., Nishri, D., Yosef, Y., Blumkin, L., Lev, D., Leshinsky‐Silver, E., Kivity, S., & Lerman‐Sagie, T. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03715.x · Cited by 11
Tobacco habits in nocturnal frontal lobe epilepsy
Naldi, I., Bisulli, F., Vignatelli, L., Licchetta, L., Pittau, F., Vito, L. D., Mostacci, B., Menghi, V., Provini, F., Montagna, P., et al. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.10.014 · Cited by 14

Authors: Willoughby, J. O., Pope, K. J., & Eaton, V.
Affiliations: Flinders University (AU)
ORCID: Willoughby, John O.
Pope, Kenneth J.
Eaton, Vaughn
Venue: Epilepsia
Publisher: Wiley
Published: 2003-08-12
Volume: 44
Issue: 9
Pages: 1238-1240
ISSN: 0013-9580 (ISSN-L)
1528-1167
DOI: 10.1046/j.1528-1157.2003.58102.x-i1
OpenAlex: W1985571774
Cited by: 80
References: 6
Citations by year: 2026: 2 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 8 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 5
FWCI: 1.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Epilepsia (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: nicotine, nicotine patch, autosomal dominant nocturnal frontal lobe epilepsy, drug-resistant epilepsy, anticonvulsant therapy, seizure frequency, open-label extension
MeSH terms: Administration, Cutaneous, Adult, Anticonvulsants, Double-Blind Method, Female, Humans, Mutation, Nicotine, Epilepsy, Frontal Lobe

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Nicotine as an Antiepileptic Agent in ADNFLE: An N‐of‐One Study

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