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Inflammation and thrombosis
Open accessAbstract
Systemic inflammation is a potent prothrombotic stimulus. Inflammatory mechanisms upregulate procoagulant factors, downregulate natural anticoagulants and inhibit fibrinolytic activity. In addition to modulating plasma coagulation mechanisms, inflammatory mediators appear to increase platelet reactivity. In vivo, however, natural anticoagulants not only prevent thrombosis, but they also dampen inflammatory activity. Some insights into the evolution and linkages between inflammatory mechanisms and the coagulation/anticoagulation mechanisms have become evident from recent structural studies. This review will summarize the interactions between inflammation and coagulation.
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From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [75]
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Metadata
- Authors
- Esmon, C. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Esmon, C.T.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 1
- Issue
- 7
- Pages
- 1343-1348
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W2024773717
- Cited by
- 442
- References
- 75
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 22 · 2023: 23 · 2022: 16 · 2021: 22 · 2020: 29 · 2019: 15 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 15 · 2014: 5 · 2013: 18 · 2012: 23
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- systemic inflammation, thrombosis, procoagulant factors, natural anticoagulants, fibrinolysis, platelet reactivity, coagulation, inflammatory mediators
- MeSH terms
- Animals, Anticoagulants, Antithrombins, Endothelium, Vascular, Humans, Inflammation, Lipoproteins, Models, Biological, Protein C, Thrombin, Thrombosis, Down-Regulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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