Cited by 442Blood Coagulation and Thrombosis MechanismsBlood properties and coagulationPlatelet Disorders and Treatments

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Inflammation and thrombosis

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Esmon, C.T.·2003·Journal of Thrombosis and Haemostasis

DOI 10.1046/j.1538-7836.2003.00261.x

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Abstract

Systemic inflammation is a potent prothrombotic stimulus. Inflammatory mechanisms upregulate procoagulant factors, downregulate natural anticoagulants and inhibit fibrinolytic activity. In addition to modulating plasma coagulation mechanisms, inflammatory mediators appear to increase platelet reactivity. In vivo, however, natural anticoagulants not only prevent thrombosis, but they also dampen inflammatory activity. Some insights into the evolution and linkages between inflammatory mechanisms and the coagulation/anticoagulation mechanisms have become evident from recent structural studies. This review will summarize the interactions between inflammation and coagulation.

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See all 442

Authors: Esmon, C. T.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Esmon, C.T.
Venue: Journal of Thrombosis and Haemostasis
Publisher: Elsevier BV
Published: 2003-07
Volume: 1
Issue: 7
Pages: 1343-1348
ISSN: 1538-7836 (ISSN-L)
DOI: 10.1046/j.1538-7836.2003.00261.x
OpenAlex: W2024773717
Cited by: 442
References: 75
Citations by year: 2026: 17 · 2025: 22 · 2024: 22 · 2023: 23 · 2022: 16 · 2021: 22 · 2020: 29 · 2019: 15 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 15 · 2014: 5 · 2013: 18 · 2012: 23
FWCI: 3.73
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7104 d)
Locations: Journal of Thrombosis and Haemostasis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Hematology › Blood properties and coagulation
Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords: systemic inflammation, thrombosis, procoagulant factors, natural anticoagulants, fibrinolysis, platelet reactivity, coagulation, inflammatory mediators
MeSH terms: Animals, Anticoagulants, Antithrombins, Endothelium, Vascular, Humans, Inflammation, Lipoproteins, Models, Biological, Protein C, Thrombin, Thrombosis, Down-Regulation

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