Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.

Melamed, Samuel; Shirom, Arie; Toker, Sharon; Berliner, Shlomo; Shapira, Itzhak

doi:10.1037/0033-2909.132.3.327

Cited by 943Stress and Burnout ResearchOccupational Health and BurnoutWorkplace Health and Well-being

Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.

Melamed, Samuel, Shirom, Arie, Toker, Sharon, Berliner, Shlomo, Shapira, Itzhak·2006·Psychological Bulletin

DOI 10.1037/0033-2909.132.3.327

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Abstract

Burnout is characterized by emotional exhaustion, physical fatigue, and cognitive weariness, resulting from prolonged exposure to work-related stress. The authors review the accumulated evidence suggesting that burnout and the related concept of vital exhaustion are associated with increased risk of cardiovascular disease and cardiovascular-related events. The authors present evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor health behaviors. The association of burnout and vital exhaustion with these disease mediators suggests that their impact on health may be more extensive than currently indicated.

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Authors: Melamed, S., Shirom, A., Toker, S., Berliner, S., & Shapira, I.
Affiliations: Tel Aviv University (IL)
Tel Aviv Sourasky Medical Center (IL)
ORCID: Toker, Sharon
Venue: Psychological Bulletin
Publisher: American Psychological Association (APA)
Published: 2006
Volume: 132
Issue: 3
Pages: 327-353
ISSN: 0033-2909 (ISSN-L)
1939-1455
DOI: 10.1037/0033-2909.132.3.327
OpenAlex: W2062679887
Semantic Scholar: b3c222f37c85c1a78d7743b9720ca4407af2e1d7
Cited by: 943
References: 370
Citations by year: 2026: 30 · 2025: 46 · 2024: 46 · 2023: 53 · 2022: 39 · 2021: 58 · 2020: 54 · 2019: 52 · 2018: 45 · 2017: 66 · 2016: 40 · 2015: 53 · 2014: 51 · 2013: 50 · 2012: 65
FWCI: 4.74
Type: journal article
Language: en
Open access: closed
Locations: Psychological Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: Israel Science Foundation (962/02-1)
Government of Israel
Topics: Social Sciences › Psychology › Social Psychology › Stress and Burnout Research
Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Burnout
Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
Keywords: burnout, vital exhaustion, cardiovascular disease, occupational stress, emotional exhaustion, metabolic syndrome, hypothalamic-pituitary-adrenal axis, sympathetic activation, sleep disorders, systemic inflammation, coagulation, fibrinolysis, health behavior, causal pathways
MeSH terms: Burnout, Professional, Cardiovascular Diseases, Depression, Humans, Research Design

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Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.

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