Brugada syndrome and supraventricular tachyarrhythmias: a novel association?
Open accessAbstract
Brugada Syndrome and Supraventricular Tachyarrhythmias. Introduction: The Brugada syndrome is a distinct form of idiopathic ventricular fibrillation characterized by a unique ECG pattern consisting of a right bundle branch block‐like aspect and ST segment elevation in leads V 1 to V 3. As a high induction rate of ventricular tachyarrhythmias has been reported in Brugada syndrome, we hypothesized that this also may be true for supraventricular tachycardias in these patients. Methods and Results: Between January 1995 and December 2000, we identified 35 consecutive patients with Brugada syndrome; 26 had a history of cardiac arrest or syncope and 9 were asymptomatic. All patients underwent electrophysiologic study, including an atrial and ventricular stimulation protocol. Ten patients (29%) were found to have supraventricular tachyarrhythmias (SVT) in addition to the Brugada syndrome. These 10 patients presented with aborted sudden cardiac death (n = 3) and/or a family history of sudden cardiac death (n = 4), syncope (n = 4), or primarily with a Brugada typical ECG, a positive family history, and palpitations (n = 2). Eight of them underwent genetic testing, but only 1 had a mutation in the SCN5A gene. In 6 patients, an AV nodal reentrant tachycardia was easily and reproducibly inducible. Two patients had clinical documented and inducible episodes of an atrial tachycardia (1 in addition to an AV nodal reentrant tachycardia). One patient had paroxysmal atrial fibrillation alternating with sinus rhythm, and 2 patients with accessory pathways were identified. Conclusion: This is the first description of an association of the Brugada syndrome with SVT. Thus, the arrhythmogenic substrate in Brugada syndrome may not be restricted to the ventricular level. Palpitations in this syndrome should raise the possibility of SVT. Conversely, in patients with SVT and aborted sudden cardiac death or syncope not related to SVT, the Brugada syndrome should be considered a possible additional electrophysiologic abnormality.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AF prevalence in Brugada syndrome is 10-20%.
“Brugada syndrome SCN5A GPDIL SCN1B CACNA1C CACNB2b others INa INa INa ICa ICa others 10-20% 851-855”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [851]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Still being checked.
Research works printed but not linked: 17
- Brugada P, Brugada J: Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Car- diol 1992;20:1391-1396.
- Alings M, Wilde A: "Brugada" syndrome: Clinical data and suggested pathophysiological mechanism. Circulation 1999;99:666-673.
- Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz LR, Wang Z, Antzelevitch C, O' Brien RE, Schulze BE, Keating MT, Towbin JA, Wang Q: Genetic basis and molecular mechanism for idiopathic ven- tricular brillation. Nature 1998;392:293-296.
- Antzelevitch C: The Brugada syndrome: Ionic basis and arrhythmia mechanisms. J Cardiovasc Electrophysiol 2001;12:268-272.
- Brugada J, Brugada P, Brugada R: The syndrome of right bundle branch block ST segment elevation in V1 to V3 and sudden death: The Brugada syndrome. Europace 1999;1:156-166.
- Eckardt L, Kirchhof P, Johna R, Haverkamp W, Breithardt G, Borg- grefe M: WPW syndrome associated with Brugada syndrome. PACE 2001; (In press).
- Kakishita M, Kurita T, Matsuo K, Taguchi A, Suyama K, Shimizu W, Aihara N, Kamakura S, Yamamoto F, Kobayashi J, Kosakai, Ohe T: Mode of onset of ventricular brillation in patients with Brugada syndrome detected by implantable cardioverter de brillator therapy. J Am Coll Cardiol 2000;36:1646-1653.
- Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR: The Brugada syndrome: Clinical, electrophysiologic and genetic as- pects. J Am Coll Cardiol 1999;33:5-15.
- Kirchhof P, Eckardt L, Mo ¨nnig G, Johna R, Loh P, Schulze-Bahr E, Breithardt G, Borggrefe M, Haverkamp W: A patient with "atrial torsades de pointes." J Cardiovasc Electrophysiol 2000;11:806-811.
- Priori SG, Napolitano C, Gasparini M, Pappone C, Della BP, Brignole M, Giordano U, Giovannini T, Menozzi C, Bloise R, Crotti L, Terreni L, Schwartz PJ: Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families. Circulation 2000;102:2509-2515.
- Montoya PT, Brugada P, Smeets J, Talajic M, Della Bella P, Lezaun R, vd Dool A, Wellens HJ, Bayes de Luna A, Oter R, Breithardt G, Borggrefe M, Klein H, Kuck KH, Kunze K, Coumel P, Leclercq JF, Chouty F, Frank R, Fontaine G: Ventricular brillation in the Wolff- Parkinson-White syndrome. Eur Heart J 1991;12:144-150.
- Pietersen AH, Andersen ED, Sandoe E: Atrial brillation in the Wolff- Parkinson-White syndrome. Am J Cardiol 1992;70:38A-43A.
- Leitch JW, Klein GJ, Yee R, Leather RA, Kim YH: Syncope associ- ated with supraventricular tachycardia. An expression of tachycardia rate or vasomotor response? Circulation 1992;85:1064-1071.
- O ¨berg B, Thore ´n P: Increased activity in left ventricular receptors during hemorrhage or occlusion of caval veins in the cat: A possible cause of the vaso-vagal reaction. Acta Physiol Scand 1972;85:164-173.
- Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S: Autonomic and antiarrhythmic drug modulation of ST segment eleva- tion in patients with Brugada syndrome. J Am Coll Cardiol 1996;27: 1061-1070.
- Brugada R, Brugada J, Antzelevitch C, Kirsch GE, Potenza D, Towbin JA, Brugada P: Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation 2000;101:510-515.
- Eckardt et al. Brugada Syndrome and Supraventricular Tachyarrhythmias 685 15408167, 2001, 6, Downloaded from https://onlinelibrary.wiley.com/doi/10.1046/j.1540-8167.2001.00680.x by Mount Vernon Nazarene University, Wiley Online Library on [23/06/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
Cited by
Sorted by citations
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Self-citationPathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273 · see citing works
Self-citationProposed Diagnostic Criteria for the Brugada Syndrome
Wilde, A. A. M., Antzelevitch, C. N., Borggrefe, M. M., Brugada, J., Brugada, R., Brugada, P., Corrado, D., Hauer, R. N. W., Kass, R. S., Nademanee, K., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034169.45752.4a · Cited by 844 · see citing works
Self-citationGoette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 785 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · EP Europace · doi:10.1093/europace/euw161 · Cited by 782 · see citing works
Short QT Syndrome: A Familial Cause of Sudden Death
Gaita, F., Giustetto, C., Bianchi, F., Wolpert, C., Schimpf, R., Riccardi, R., Grossi, S., Richiardi, E., & Borggrefe, M. (2003) · Circulation · doi:10.1161/01.cir.0000085071.28695.c4 · Cited by 708 · see citing works
Self-citationLong-Term Prognosis of Individuals With Right Precordial ST-Segment–Elevation Brugada Syndrome
Eckardt, L., Probst, V., Smits, J. P. P., Schulze‐Bahr, E., Wolpert, C., Schimpf, R., Wichter, T., Boisseau, P., Heinecke, A., BREITHARDT, G. E., et al. (2005) · Circulation · doi:10.1161/01.cir.0000153267.21278.8d · Cited by 447 · see citing works
Self-citationMeregalli, P. G., Wilde, A. A. M., & Tan, H. L. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.03.005 · Cited by 373 · see citing works
Proposed Diagnostic Criteria for the Brugada Syndrome
Wilde, A. A. M. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3382 · Cited by 330 · see citing works
Clinical Aspects and Prognosis of Brugada Syndrome in Children
Probst, V., Denjoy, I., Meregalli, P. G., Amirault, J.-C., Sacher, F., Mansourati, J., Babuty, D., Villain, E., Victor, J., Schott, J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.664219 · Cited by 298 · see citing works
Groenewegen, W. A., Firouzi, M., Bezzina, C. R., Vliex, S., van Langen, I. M., Sandkuijl, L. A., Smits, J. P. P., Hulsbeek, M. M. F., Rook, M. B., Jongsma, H. J., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000050585.07097.d7 · Cited by 277 · see citing works
Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome
Morita, H., Kusano-Fukushima, K., Nagase, S., Fujimoto, Y., Hisamatsu, K., Fujio, H., Haraoka, K., Kobayashi, M., Morita, S. T., Nakamura, K., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02167-8 · Cited by 262 · see citing works
Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation
Watanabe, H., Darbar, D., Kaiser, D. W., Jiramongkolchai, K., Chopra, S. S., Donahue, B. S., Kannankeril, P. J., & Roden, D. M. (2009) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.108.779181 · Cited by 246 · see citing works
Kirchhof, P. F., Lip, G. Y. H., Gelder, I. C. V., Bax, J. J., Hylek, E. M., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Brandes, A., et al. (2011) · EP Europace · doi:10.1093/europace/eur241 · Cited by 242 · see citing works
Self-citationAtrial Fibrillation in Patients With Brugada Syndrome
Kusano, K. F., Taniyama, M., Nakamura, K., Miura, D., Banba, K., Nagase, S., Morita, H., Nishii, N., Watanabe, A., Tada, T., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.060 · Cited by 190 · see citing works
Incidence, clinical implications and prognosis of atrial arrhythmias in brugada syndrome
Bordachar, P. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.01.004 · Cited by 161 · see citing works
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.05.002 · Cited by 148 · see citing works
Fabritz, L., Guasch, E., Antoniades, C. A., Bardinet, I., Benninger, G., Betts, T. R., Brand, E., BREITHARDT, G. E., Suchánková, G., Camm, A. J., et al. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.194 · Cited by 142 · see citing works
Self-citationAtrial fibrillation and Brugada syndrome.
Francis, J., & Antzelevitch, C. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.062 · Cited by 121 · see citing works
Benito, B., Brugada, R., Brugada, J., & Brugada, P. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.05.002 · Cited by 115 · see citing works
Eckardt, L. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3256 · Cited by 114 · see citing works
Self-citationKirchhof, P. F., Bax, J. J., Blomstrom-Lundquist, C., Calkins, H., Camm, A. J., Cappato, R., Cosío, F. G., Crijns, H. J. G. M., Diener, H., Goette, A., et al. (2009) · EP Europace · doi:10.1093/europace/eup124 · Cited by 110 · see citing works
Self-citationJunttila, J. M. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.01.011 · Cited by 104 · see citing works
Hasdemir, C., Payzin, S., Kocabas, U., Sahin, H., Yildirim, N., Alp, A., Aydin, M., Pfeiffer, R., Burashnikov, E., Wu, Y., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.03.015 · Cited by 101 · see citing works
Nielsen, J. C., Lin, Y., Figueiredo, M. J. D. O., Shamloo, A. S., Alfie, A., Bovéda, S., Dagres, N., Toro, D. D., Eckhardt, L. L., Ellenbogen, K. A., et al. (2020) · Journal of Arrhythmia · doi:10.1002/joa3.12338 · Cited by 102 · see citing works
Nielsen, J. C., Lin, Y.-J., de Oliveira Figueiredo, M. J., Sepehri Shamloo, A., Alfie, A., Boveda, S., Dagres, N., Di Toro, D., Eckhardt, L. L., Ellenbogen, K., et al. (2020) · EP Europace · doi:10.1093/europace/euaa065 · Cited by 98 · see citing works
Self-citationDrug-Induced Brugada Syndrome in Children
Conte, G., Dewals, W., Sieira, J. A., de Asmundis, C., Ciconte, G., Chierchia, G., Giovanni, G. D., Baltogiannis, G., Saitoh, Y., Moisés Levinstein, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.574 · Cited by 92 · see citing works
Benito, B., Brugada, R., Perich, R. M., Lizotte, É., Juan Cinca, A., Mont, L., Berruezo, A., Tolosana, J. M., Freixa, X., Brugada, P., et al. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.07.013 · Cited by 91 · see citing works
SCN5A Mutation Associated with Cardiac Conduction Defect and Atrial Arrhythmias
Laitinen-Forsblom, P. J., Mäkynen, P. J., Mäkynen, H., Yli‐Mäyry, S., Virtanen, V., KONTULA, K. K., & Aalto‐Setälä, K. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00411.x · Cited by 90 · see citing works
An Introduction to Murine Models of Atrial Fibrillation
Riley, G., Syeda, F., Kirchhof, P. F., & Fabritz, L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00296 · Cited by 74 · see citing works
Self-citationPappone, C., Radinovic, A., Manguso, F., Vicedomini, G., Sala, S., Sacco, F. M., Ciconte, G., Saviano, M., Ferrari, M., Sommariva, E., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp326 · Cited by 64 · see citing works
Singh, M., Morin, D. P., & Link, M. S. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.05.006 · Cited by 66 · see citing works
Clinical predictors of atrial fibrillation in Brugada syndrome
Bigi, M. A. B., Aslani, A., & Shahrzad, S. (2007) · EP Europace · doi:10.1093/europace/eum110 · Cited by 60 · see citing works
Camm, A. J., Savelieva, I., Ho, S. Y., Lindsay, B. D., Nattel, S., & Shinagawa, K. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4377-0285-9.00044-2 · Cited by 60 · see citing works
Everybody has Brugada syndrome until proven otherwise?
Viskin, S., Rosso, R., Friedensohn, L., Havakuk, O., & Wilde, A. A. M. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.04.017 · Cited by 56 · see citing works
Sinus Node Function in Patients With Brugada-Type ECG
Morita, H., Fukushima‐Kusano, K., Nagase, S., Miyaji, K., Hiramatsu, S., Banba, K., Nishii, N., Watanabe, A., Kakishita, M., Morita, S. T., et al. (2004) · Circulation Journal · doi:10.1253/circj.68.473 · Cited by 53 · see citing works
Prevention of inappropriate ICD shocks in patients with Brugada syndrome
Veltmann, C., Kuschyk, J., Schimpf, R., Streitner, F., Schoene, N., Borggrefe, M. M., & Wolpert, C. (2009) · Clinical Research in Cardiology · doi:10.1007/s00392-009-0075-4 · Cited by 52 · see citing works
Self-citationPrevalence of Supraventricular Tachyarrhythmias in a Cohort of 115 Patients with Brugada Syndrome
Schimpf, R., Giustetto, C., Eckardt, L., Veltmann, C., Wolpert, C., Gaïta, F., Breithardt, G., & Borggrefe, M. (2008) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2008.00230.x · Cited by 51 · see citing works
Self-citationBrugada, P., Brugada, J., & Brugada, R. (2002) · Cardiac Electrophysiology Review · doi:10.1023/a:1017978903909 · Cited by 47 · see citing works
Darmon, J.-P., Bettouche, S., Deswardt, P., Tiger, F., Ricard, P., Bernasconi, F., & Saoudi, N. C. (2004) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/b:jice.0000048571.19462.54 · Cited by 43 · see citing works
Modelling of short QT syndrome in a heterogeneous model of the human ventricular wall
Weiss, D. L., Seemann, G., Sachse, F. B., & Dössel, O. (2005) · EP Europace · doi:10.1016/j.eupc.2005.04.008 · Cited by 43 · see citing works
Nielsen, J. C., Lin, Y., Figueiredo, M. J. D. O., Shamloo, A. S., Alfie, A., Bovéda, S., Dagres, N., Toro, D. D., Eckhardt, L. L., Ellenbogen, K. A., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.05.004 · Cited by 42 · see citing works
Self-citationBrugada Syndrome – A Review of the Implications for the Anaesthetist
Carey, S. M., & Hocking, G. (2011) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1103900406 · Cited by 40 · see citing works
HISAMATSU, K., KUSANO, K. F., Morita, H., Morita, S. T., Nagase, S., Nakamura, K., Emori, T., Matsubara, H., Mikouchi, H., NISHIZAKI, Y., et al. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.03675.x · Cited by 40 · see citing works
Yamada, T., Watanabe, I., Okumura, Y., Takagi, Y., Okubo, K., Hashimoto, K., Shindo, A., Nakai, T., Kasamaki, Y., & Saito, S. (2006) · Circulation Journal · doi:10.1253/circj.70.1574 · Cited by 39 · see citing works
The Diagnosis, Risk Stratification, and Treatment of Brugada Syndrome
Steinfurt, J., Biermann, J., Bode, C., & Odening, K. E. (2015) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2015.0394 · Cited by 36 · see citing works
Atrial fibrillation in Brugada syndrome: Current perspectives
Vlachos, K., Mascia, G., Martin, C. A., Bazoukis, G., Frontera, A., Cheniti, G., Letsas, K., Efremidis, M., Georgopoulos, S., Gkalapis, C., et al. (2020) · Cardiovascular Electrophysiology · doi:10.1111/jce.14361 · Cited by 30 · see citing works
Leitlinie invasive elektrophysiologische Diagnostik
Willems, S., Eckardt, L., Hoffmann, E., Klemm, H. U., PITSCHNER, H. F., Reithmann, C., Tebbenjohanns, J., & Zrenner, B. (2007) · Clinical Research in Cardiology · doi:10.1007/s00392-007-0572-2 · Cited by 28 · see citing works
Self-citationElectrocardiogram interpretation and class I blocker challenge in Brugada syndrome
Brugada, R., Brugada, P., & Brugada, J. (2006) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2006.05.014 · Cited by 28 · see citing works
Letsas, Κ. P., Sideris, A., Efremidis, M., Pappas, L. K., Gavrielatos, G. D., Filippatos, G. S., & Kardaras, F. G. (2007) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e3280112b21 · Cited by 27 · see citing works
Hermida, J., Jandaud, S., Lemoine, J.-L., Rodriguez‐Lafrasse, C., Delonca, J., Bertrand, C., JARRY, G., Rochette, J., & Rey, J.-L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.03.072 · Cited by 27 · see citing works
Brugada Syndrome: Current Clinical Aspects and Risk Stratification
Ikeda, T. (2002) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2002.tb00172.x · Cited by 27 · see citing works
Zumhagen, S., Veldkamp, M. W., Stallmeyer, B., Baartscheer, A., Eckardt, L., Paul, M., Remme, C. A., Bhuiyan, Z. A., Bezzina, C. R., & Schulze‐Bahr, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067963 · Cited by 26 · see citing works
Self-citationBertomeu‐González, V., Ruiz‐Granell, R., García–Civera, R., Morell‐Cabedo, S., & Ferrero, A. (2006) · EP Europace · doi:10.1093/europace/eul117 · Cited by 26 · see citing works
Clinical Characteristics of Brugada Syndrome in a Korean Population
Park, D., Nam, G., Rhee, K., Han, G.-H., Choi, K., & Kim, Y. (2003) · Circulation Journal · doi:10.1253/circj.67.934 · Cited by 26 · see citing works
Naccarelli, G. V., Antzelevitch, C. N., Wolbrette, D. L., & Luck, J. C. (2002) · Current Opinion in Cardiology · doi:10.1097/00001573-200201000-00003 · Cited by 23 · see citing works
Junttila, J. M., Raatikainen, M. J. P., Perkiömäki, J. S., Hong, K., Brugada, R., & Huikuri, H. V. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl474 · Cited by 22 · see citing works
Acute aortic dissection provoked by sneeze: a case report
Baydın, A. (2005) · Emergency Medicine Journal · doi:10.1136/emj.2004.014829 · Cited by 22 · see citing works
Brugada and Long QT‐3 Syndromes: Two Phenotypes of the Sodium Channel Disease
Khan, I. A., & Nair, C. K. (2004) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2004.93533.x · Cited by 21 · see citing works
Francis, J., & Antzelevitch, C. N. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.03.068 · Cited by 21 · see citing works
T Wave Alternans Does not Assess Arrhythmic Risk in Patients with Brugada Syndrome
Kirchhof, P. F., Eckardt, L., Rolf, S., Esperer, H. D., Paul, M., Wichter, T., Klein, H., BREITHARDT, G. E., & Böcker, D. (2004) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2004.92541.x · Cited by 20 · see citing works
Self-citationUeyama, T., Shimizu, A., 山縣, 俊., Esato, M., Ohmura, M., Yoshiga, Y., Kanemoto, M., Kametani, R., Sawa, A., Suzuki, S., et al. (2006) · Circulation Journal · doi:10.1253/circj.71.57 · Cited by 20 · see citing works
Atrial Fibrillation and Recurrent Ventricular Fibrillation During Hypokalemia in Brugada Syndrome
Notarstefano, P., Pratola, C., Toselli, T., & Ferrari, R. (2005) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2005.00277.x · Cited by 20 · see citing works
Coexistence of atrioventricular accessory pathways and drug‐induced type 1 Brugada pattern
Hasdemir, C., Juang, J. J., Köse, S., Kocabaş, U., Orman, M. N., Payzın, S., Şahin, H., Celen, C., Özcan, E. E., Chen, C. J., et al. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13414 · Cited by 19 · see citing works
BELDNER, S. J., Lin, D., & Marchlinski, F. E. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.07.091 · Cited by 19 · see citing works
Sinus Node Dysfunction Concomitant With Brugada Syndrome
Sumiyoshi, M., Nakazato, Y., Tokano, T., Yasuda, M., Mineda, Y., Nakata, Y., & Daida, H. (2005) · Circulation Journal · doi:10.1253/circj.69.946 · Cited by 18 · see citing works
Predictors of Atrial Tachyarrhythmias in Subjects with Type 1 ECG Pattern of Brugada Syndrome
Letsas, Κ. P., Weber, R., Astheimer, K., Mihas, C. C., Stockinger, J., BLUM, T., Kalusche, D., & Arentz, T. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02311.x · Cited by 16 · see citing works
Nakano, Y., Shimizu, W., Ogi, H., Suenari, K., Oda, N., Makita, Y., Kajihara, K., Hirai, Y., Sairaku, A., Tokuyama, T., et al. (2010) · EP Europace · doi:10.1093/europace/eup446 · Cited by 15 · see citing works
Wolff‐Parkinson‐White Syndrome Concomitant with Asymptomatic Brugada Syndrome
Ohkubo, K., Watanabe, I., Okumura, Y., Yamada, T., Hashimoto, K., Masaki, R., Oshikawa, N., Kofune, T., Wakita, R., Takagi, Y., et al. (2004) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2004.00396.x · Cited by 15 · see citing works
Electrocardiographic predictors of Brugada type response during Na channel blockade challenge
Js, H., Denjoy, I., JARRY, G., Jandaud, S., Bertrand, C., & Delonca, J. (2005) · EP Europace · doi:10.1016/j.eupc.2005.05.005 · Cited by 15 · see citing works
Escárcega, R. O., Jiménez-Hernández, M., García-Carrasco, M., Pérez-Alva, J., & Brugada, J. (2009) · Acta Cardiologica · doi:10.2143/ac.64.6.2044745 · Cited by 12 · see citing works
Brugada syndrome, manifested by propafenone induced ST segment elevation
Aksay, E. (2005) · Emergency Medicine Journal · doi:10.1136/emj.2003.013789 · Cited by 14 · see citing works
Incidence of Atrial Tachyarrhythmias in Patients With Early Repolarization Syndrome
Hwang, K. W., Nam, G., Han, J., Kim, Y. G., Choi, H. O., Kim, J., Choi, K., & Kim, Y. (2017) · International Heart Journal · doi:10.1536/ihj.16-104 · Cited by 13 · see citing works
Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes
Zhang, H., Ji, H., Liu, Z., Ji, Y., Xinmin, Y., Ding, G., & Cheng, Z.-J. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1449-1 · Cited by 13 · see citing works
Monomorphic ventricular tachycardia in Brugada syndrome: True-true but related?
Eckhardt, L. L. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.11.039 · Cited by 13 · see citing works
Kofune, M., Watanabe, I., Ohkubo, K., Ashino, S., Okumura, Y., Nagashima, K., Nakai, T., Kasamaki, Y., & Hirayama, A. (2010) · International Heart Journal · doi:10.1536/ihj.51.159 · Cited by 11 · see citing works
Genetics and Sinus Node Dysfunction.
Nof, E., Glikson, M., & Antzelevitch, C. N. (2009) · PubMed Central · doi:10.4022/jafib.151 · Cited by 12 · see citing works
Manifestation of Brugada Syndrome After Pacemaker Implantation in a Patient with Sick Sinus Syndrome
Nakazato, Y., SUZUKI, T., YASUDA, M., & Daida, H. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.04092.x · Cited by 12 · see citing works
Value of 12 Lead Electrocardiogram and Derived Methodologies in the Diagnosis of Brugada Disease
Riera, A. R. P., Ferreira, C., & Schapachnik, E. (2005) · doi:10.1002/9780470994900.ch7 · Cited by 11 · see citing works
Furukawa, Y., Yamada, T., Okuyama, Y., Morita, T., Tanaka, K., Iwasaki, Y., Ueda, H., Okada, T., Kawasaki, M., Kuramoto, Y., et al. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2011.03122.x · Cited by 10 · see citing works
Takahashi, N., Shinohara, T., Hara, M., & Saikawa, T. (2012) · Internal Medicine · doi:10.2169/internalmedicine.51.7353 · Cited by 10 · see citing works
Increased dispersion of atrial repolarization in Brugada syndrome
Choi, K.-J., Kim, J., Kim, S., Nam, G.-B., & Kim, Y. (2011) · EP Europace · doi:10.1093/europace/eur148 · Cited by 10 · see citing works
More than 30 years of Brugada syndrome: a critical appraisal of achievements and open issues
Eckardt, L., & Veltmann, C. (2023) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-023-00983-y · Cited by 9 · see citing works
Self-citationHasdemir, H., Alper, A. T., Güvenç, T. S., Arslan, Y., Aksu, H., Poyraz, E., Nurkalem, Z., ORHAN, A. L., & Çakmak, N. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02997.x · Cited by 9 · see citing works
Brugada Syndrome Unmasked by Accidental Inhalation of Gasoline Vapors
Kranjčec, D., Bergovec, M., Rougier, J., Raguž, M., Pavlović, S., Jespersen, T., Castella, V., Keller, D. I., & Abriel, H. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00857.x · Cited by 9 · see citing works
Kirchhof, P. F., Haas, S. K., Amarenco, P., Turpie, A. G. G., Bach, M., Lambelet, M., Hess, S., & Camm, A. J. (2024) · EP Europace · doi:10.1093/europace/euae183 · Cited by 8 · see citing works
Self-citationTreatment of Anxiety and Depression in a Patient with Brugada Syndrome
Chen, J. J., & Sangha, R. S. (2014) · Case Reports in Psychiatry · doi:10.1155/2014/478397 · Cited by 7 · see citing works
Long QT genetics manifesting as atrial fibrillation
Guerrier, K., Czosek, R. J., Spar, D. S., & Anderson, J. B. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.07.012 · Cited by 7 · see citing works
Clinical observations of supraventricular arrhythmias in patients with brugada syndrome.
Liu, B., Guo, C., Fang, D., & Guo, J.-P. (2015) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Brugada syndrome: Controversies in Risk stratification and Management.
Nunn, L., Bhar-Amato, J., & Lambiase, P. D. (2010) · PubMed Central · Cited by 6 · see citing works
Trans-sternal cardiac injury caused by a hooked needle
Yanar, H. T. (2005) · Emergency Medicine Journal · doi:10.1136/emj.2004.014779 · Cited by 7 · see citing works
Characteristics of subjects with Brugada syndrome type electrocardiogram
Junttila, J. M. (2008) · Cited by 7 · see citing works
Does noninvasive ventilation work in ARDS? A case report and review of the current literature
Malhotra, P. (2005) · Emergency Medicine Journal · doi:10.1136/emj.2003.013995 · Cited by 6 · see citing works
Satish, O. S., Yeh, K.-H., & Wen, M. (2005) · PubMed · Cited by 6 · see citing works
Brugada-like electrocardiographic pattern: A challenge for the clinician
Grande, A., Tomaselli, V., Massarelli, L., Amico, S., Bellanuova, I., & Barbera, A. (2005) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2005.07.010 · Cited by 6 · see citing works
Recent Status in Brugada Syndrome.
Bayrak, F., & Brugada, P. (2022) · Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır · doi:10.5543/tkda.2022.21020 · Cited by 3 · see citing works
Characteristics of patients with Brugada syndrome and monomorphic ventricular tachycardia
Monaco, C., Bénali, K., Fernández, M. C., Bouteiller, X. P., Monte, A. D., Pannone, L., Surget, E., Mascia, G., Notarstefano, P., Menè, R., et al. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.06.025 · Cited by 5 · see citing works
Cardiac amyloidosis and Brugada-like ECG pattern
Bramos, D., Koutras, K., Kollias, G. E., Prappa, E., Letsas, Κ. P., & Sideris, A. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.08.045 · Cited by 5 · see citing works
- Authors
- ECKARDT, L., KIRCHHOF, P., LOH, P., SCHULZE‐BAHR, E., JOHNA, R., WICHTER, T., BREITHARDT, G., HAVERKAMP, W., & BORGGREFE, M.
- Affiliations
- University of Münster (DE)
- Heidelberg University (DE)
- Corresponding author
- ECKARDT, LARS
- HAVERKAMP, WILHELM
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 12
- Issue
- 6
- Pages
- 680-685
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W1986672101
- Cited by
- 159
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- Brugada syndrome, supraventricular tachyarrhythmias, atrioventricular nodal reentrant tachycardia, atrial tachycardia, paroxysmal atrial fibrillation, accessory pathway, sudden cardiac death, syncope, electrophysiological study, arrhythmogenic substrate, SCN5A mutation
- MeSH terms
- Adult, Bundle-Branch Block, Cardiac Pacing, Artificial, Electrocardiography, Female, Heart Arrest, Humans, Male, Middle Aged, Retrospective Studies, Tachycardia, Supraventricular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
