Cited by 124Cardiac electrophysiology and arrhythmiasCardiac Arrhythmias and TreatmentsIon channel regulation and function

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Prolonged Atrial Action Potential Durations and Polymorphic Atrial Tachyarrhythmias in Patients with Long QT Syndrome

KIRCHHOF, PAULUS, ECKARDT, LARS, FRANZ, MICHAEL R., MÖNNIG, GEROLD, LOH, PETER, WEDEKIND, HORST, SCHULZE‐BAHR, ERIC, BREITHARDT, GÜNTER, HAVERKAMP, WILHELM·2003·Journal of Cardiovascular Electrophysiology

DOI 10.1046/j.1540-8167.2003.03165.x

Open this paper in CoChat — free account

Abstract

UNLABELLED: Atrial APD and Polymorphic AT in LQTS. INTRODUCTION: Prolongation of the QT interval and torsades de pointes tachycardias due to altered expression or function of repolarizing ion channels are the hallmark of congenital long QT syndrome (LQTS). The same ion channels also contribute to atrial repolarization, and familial atrial fibrillation may be associated with a mutated KVLQT1 gene. We therefore assessed atrial action potential characteristics and atrial arrhythmias in LQTS patients. METHODS AND RESULTS: Monophasic action potentials (MAPs) were simultaneously recorded from the right atrial appendage and the inferolateral right atrium in 10 patients with LQTS (8 with identifiable genotype) and compared to 7 control patients. Atrial arrhythmias also were compared to MAPs recorded in patients with persistent (n = 10) and induced (n = 4) atrial fibrillation. Atrial action potential durations (APD) and effective refractory periods (ERP) were prolonged in LQTS patients at cycle lengths of 300 to 500 msec (APD prolongation 30-41 msec; ERP prolongation 26-52 msec; all P < 0.05). Short episodes of polymorphic atrial tachyarrhythmias (polyAT, duration 4-175 sec) occurred spontaneously or during pauses after pacing in 5 of 10 LQTS patients, but not in controls (P < 0.05). P waves showed undulating axis during polyAT. Cycle lengths of polyAT were longer than during persistent and induced atrial fibrillation. Afterdepolarizations preceded polyAT in 2 patients. The electrical restitution curve was shifted to longer APD in LQTS patients and to even longer APD in LQTS patients with polyAT. CONCLUSION: This group of LQTS patients has altered atrial electrophysiology: action potentials are prolonged, and polyAT occurs. PolyAT appears to be a specific arrhythmia of LQTS reminiscent of an atrial form of "torsades de pointes".

Integrity signals

Registry

Crossref · 10.1046/j.1540-8167.2003.03165.x

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.
Haïssaguerre, M., Jaïs, P., Shah, D. C., Takahashi, A., Hocini, M., Quiniou, G., Garrigue, S., Mouroux, A. L., Métayer, P. L., & Clémenty, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809033391003 · Cited by 8,040
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
Curran, M. E., Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D., & Keating, M. T. (1995) · Cell · doi:10.1016/0092-8674(95)90358-5 · Cited by 2,253
New ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481
Spectrum of Mutations in Long-QT Syndrome Genes
Splawski, I., Shen, J., Timothy, K. W., Lehmann, M. H., Priori, S. G., Robinson, J. L., Moss, A. J., Schwartz, P. J., Towbin, J. A., Vincent, G. M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.10.1178 · Cited by 1,231
Diagnostic criteria for the long QT syndrome. An update.
Schwartz, P. J., Moss, A. J., Vincent, G. M., & Crampton, R. S. (1993) · Circulation · doi:10.1161/01.cir.88.2.782 · Cited by 1,172
KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation
Chen, Y.-H., Xu, S.-J., Bendahhou, S., Wang, X.-L., Wang, Y., Xu, W.-Y., Jin, H., Sun, H., Su, X.-Y., Zhuang, Q.-N., et al. (2003) · Science · doi:10.1126/science.1077771 · Cited by 989
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M. E., et al. (2003) · Nature · doi:10.1038/nature01335 · Cited by 957
Influence of the Genotype on the Clinical Course of the Long-QT Syndrome
Zaręba, W., Moss, A. J., Schwartz, P. J., Vincent, G. M., Robinson, J. L., Priori, S. G., Benhorin, J., Locati, E. H., Towbin, J. A., Keating, M. T., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810013391404 · Cited by 749
Pathophysiology and Prevention of Atrial Fibrillation
Allessie, M. A., Boyden, P. A., Camm, A. J., Kléber, A. G., Lab, M. J., Legato, M. J., Rosen, M. R., Schwartz, P. J., Spooner, P. M., Wagoner, D. R. V., et al. (2001) · Circulation · doi:10.1161/01.cir.103.5.769 · Cited by 724

Show all 34 references

Research works printed but not linked: 1

Liem LB, 1988, Distinctive features of ventricular fibrillation and ventricular tachycardia detected by monophasic action potential recording in human subjects, J Electrophysiol, 2, 484

Sorted by citations

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403
Self-citation
Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
Self-citation
EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 791
EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · EP Europace · doi:10.1093/europace/euw161 · Cited by 805
Outcome parameters for trials in atrial fibrillation: executive summary: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork (AFNET) and the European Heart Rhythm Association (EHRA)
Kirchhof, P. F., Auricchio, A., Bax, J. J., Crijns, H. J. G. M., Camm, A. J., Diener, H., Goette, A., Hindricks, G., Hohnloser, S., KAPPENBERGER, L. J., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm358 · Cited by 382
Self-citation
Outcome parameters for trials in atrial fibrillation: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association
Kirchhof, P., Auricchio, A., Bax, J., Crijns, H., Camm, J., Diener, H.-C., Goette, A., Hindricks, G., Hohnloser, S., Kappenberger, L., et al. (2007) · Europace · doi:10.1093/europace/eum191 · Cited by 293
Self-citation
Altered Na+Currents in Atrial Fibrillation
Sossalla, S. T., Kallmeyer, B., Wagner, S., Mazur, M. J., Maurer, U., Toischer, K., Schmitto, J. D., Seipelt, R. G., Schöndube, F. A., Hasenfuss, G. P., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.055 · Cited by 272
Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options—a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
Kirchhof, P. F., Lip, G. Y. H., Gelder, I. C. V., Bax, J. J., Hylek, E. M., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Brandes, A., et al. (2011) · EP Europace · doi:10.1093/europace/eur241 · Cited by 247
Self-citation
Electrophysiologic basis for the antiarrhythmic actions of ranolazine
Antzelevitch, C. N., Burashnikov, A., Sicouri, S., & Belardinelli, L. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.03.045 · Cited by 237
Prevalence of early-onset atrial fibrillation in congenital long QT syndrome
Johnson, J. N., Tester, D. J., Perry, J., Salisbury, B. A., Reed, C. R., & Ackerman, M. J. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.02.007 · Cited by 179
Role of potassium currents in cardiac arrhythmias
Ravens, U., & Cerbai, E. (2008) · EP Europace · doi:10.1093/europace/eun193 · Cited by 165
Congenital Long QT Syndrome
Krahn, A. D., Laksman, Z., Sy, R. W., Postema, P. G., Ackerman, M. J., Wilde, A. A. M., & Han, H. (2022) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2022.02.017 · Cited by 160
EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.05.002 · Cited by 149
Management of Atrial Fibrillation in Patients With Structural Heart Disease
Darby, A. E., & Dimarco, J. (2012) · Circulation · doi:10.1161/circulationaha.111.019935 · Cited by 141
Late‐Phase 3 EAD. A Unique Mechanism Contributing to Initiation of Atrial Fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2006) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2006.00336.x · Cited by 130
J-Shaped Association Between QTc Interval Duration and the Risk of Atrial Fibrillation
Nielsen, J. B., Graff, C., Pietersen, A. H., Lind, B., Struijk, J. J., OLESEN, M. S., Haunsø, S., Gerds, T. A., Svendsen, J. H., Køber, L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.032 · Cited by 124
QTc Interval Prolongation in Patients on Long-Term Methadone Maintenance Therapy
Maremmani, I., Pacini, M., Cesaroni, C., Lovrečić, M., Perugi, G., & Tagliamonte, A. (2004) · European Addiction Research · doi:10.1159/000081416 · Cited by 116
Congenital and Acquired Long QT Syndrome
Chiang, C. (2004) · Cardiology in Review · doi:10.1097/01.crd.0000123842.42287.cf · Cited by 112
Early and comprehensive management of atrial fibrillation: Proceedings from the 2nd AFNET/EHRA consensus conference on atrial fibrillation entitled 'research perspectives in atrial fibrillation'
Kirchhof, P. F., Bax, J. J., Blomstrom-Lundquist, C., Calkins, H., Camm, A. J., Cappato, R., Cosío, F. G., Crijns, H. J. G. M., Diener, H., Goette, A., et al. (2009) · EP Europace · doi:10.1093/europace/eup124 · Cited by 112
Self-citation
The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG)
Sinner, M. F., Pfeufer, A., Akyol, M., Beckmann, B.-M., Hinterseer, M., Wacker, A., Perz, S., Sauter, W., Illig, T., Näbauer, M., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehm619 · Cited by 107
The QT interval and risk of incident atrial fibrillation
Mandyam, M. C., Soliman, E. Z., Alonso, Á., Dewland, T. A., Heckbert, S. R., Vittinghoff, E., Cummings, S. R., Ellinor, P. T., CHAITMAN, B. R., Stocke, K. S., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.07.023 · Cited by 105
Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization
Ehrlich, J. R., Zicha, S., Coutu, P., Hébert, T. E., & Nattel, S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.03.007 · Cited by 103
Selective Molecular Potassium Channel Blockade Prevents Atrial Fibrillation
Amit, G., Kikuchi, K., Greener, I. D., Yang, L., Novack, V., & Donahue, J. K. (2010) · Circulation · doi:10.1161/circulationaha.109.911156 · Cited by 102
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population
Nielsen, J. C., Lin, Y., Figueiredo, M. J. D. O., Shamloo, A. S., Alfie, A., Bovéda, S., Dagres, N., Toro, D. D., Eckhardt, L. L., Ellenbogen, K. A., et al. (2020) · Journal of Arrhythmia · doi:10.1002/joa3.12338 · Cited by 106
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population
Nielsen, J. C., Lin, Y.-J., de Oliveira Figueiredo, M. J., Sepehri Shamloo, A., Alfie, A., Boveda, S., Dagres, N., Di Toro, D., Eckhardt, L. L., Ellenbogen, K., et al. (2020) · EP Europace · doi:10.1093/europace/euaa065 · Cited by 98
Self-citation
Impact of Genetic Discoveries on the Classification of Lone Atrial Fibrillation
Roberts, J. D., & Gollob, M. H. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.005 · Cited by 97
A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation
Benito, B., Brugada, R., Perich, R. M., Lizotte, É., Juan Cinca, A., Mont, L., Berruezo, A., Tolosana, J. M., Freixa, X., Brugada, P., et al. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.07.013 · Cited by 91
Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation
Yang, T., Yang, P., Roden, D. M., & Darbar, D. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.05.032 · Cited by 82
Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model
Lemoine, M. D., Duverger, J. E., Naud, P., Chartier, D., Qi, X. Y., Comtois, P., Fabritz, L., Kirchhof, P. F., & Nattel, S. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr166 · Cited by 82
Self-citation
Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation
Fatini, C. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl087 · Cited by 79
HDAC (Histone Deacetylase) Inhibitor Valproic Acid Attenuates Atrial Remodeling and Delays the Onset of Atrial Fibrillation in Mice
Scholz, B., Schulte, J. S., Hamer, S., Himmler, K., Pluteanu, F., Seidl, M. D., Stein, J., Wardelmann, E., Hammer, E., Völker, U., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.118.007071 · Cited by 78
Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice
Farkas, A. S., & Nattel, S. (2010) · Drugs · doi:10.2165/11535230-000000000-00000 · Cited by 74
Atrial Arrhythmias in long-QT syndrome under daily life conditions: a nested case control study
ZELLERHOFF, S., PISTULLI, R., MÖNNIG, G., HINTERSEER, M., BECKMANN, B., KÖBE, J., STEINBECK, G., KÄÄB, S., HAVERKAMP, W., FABRITZ, L., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01339.x · Cited by 71
Self-citation
Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect ofIKrandIKur/Itoblock
Burashnikov, A., Mannava, S., & Antzelevitch, C. N. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01242.2003 · Cited by 68
Multiple flavonoid-binding sites within multidrug resistance protein MRP1
Chang, X. B., Maitrejean, M., Barron, D., Riordan, J. R., Trompier, D., Baubichon-Cortay, H., & Pietro, A. D. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3177-6 · Cited by 63
Atrial Fibrillation
Camm, A. J., Savelieva, I., Ho, S. Y., Lindsay, B. D., Nattel, S., & Shinagawa, K. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4377-0285-9.00044-2 · Cited by 60
New Directions in Antiarrhythmic Drug Therapy for Atrial Fibrillation
Heijman, J., Voigt, N., & Dobrev, D. (2012) · Future Cardiology · doi:10.2217/fca.12.78 · Cited by 58
EHRA White Paper: knowledge gaps in arrhythmia management—status 2019
Goette, A., Auricchio, A., Boriani, G., Braunschweig, F., Brugada, J., Burri, H., Camm, A. J., Crijns, H. J. G. M., Dagres, N., Deharo, J., et al. (2019) · EP Europace · doi:10.1093/europace/euz055 · Cited by 57
Targeted point mutagenesis of mouse Kcnq1: phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans
Casimiro, M. C., Knollmann, B. C., Yamoah, E. N., Nie, L., Vary, J. C., Sirenko, S., Greene, A. E., Grinberg, A., Huang, S. P., Ebert, S. N., et al. (2004) · Genomics · doi:10.1016/j.ygeno.2004.06.007 · Cited by 53
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability
Blana, A., Kaese, S., Fortmueller, L., Laakmann, S., Damke, D., van Bragt, K. A., Eckstein, J., Piccini, I., Kirchhefer, U., Nattel, S., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.08.016 · Cited by 52
Self-citation
Role of Late Sodium Channel Current Block in the Management of Atrial Fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6421-1 · Cited by 49
Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure
Schmidt, C., Wiedmann, F., Kallenberger, S. M., Büscher, A., Schulte, J. S., Scholz, B., Müller, F. U., Voigt, N., Zafeiriou, M.-P., Ehrlich, J. R., et al. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.05.004 · Cited by 51
Atrial fibrillation in young patients
Gourraud, J., Khairy, P., Abadir, S., Tadros, R., Cadrin‐Tourigny, J., Macle, L., Dyrda, K., Mondesert, B. A., Dubuc, M., Guerra, P. G., et al. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2018.1490644 · Cited by 50
TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control
Lugenbiel, P., Wenz, F., Syren, P., Geschwill, P., Govorov, K., Seyler, C., Frank, D., Schweizer, P. A., Franke, J., Weis, T., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0597-7 · Cited by 48
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta‐analysis
Zhang, N., Gong, M., Tse, G., Zhang, Z., Meng, L., Yan, B. P., Zhang, L., Wu, G., Xia, Y., Xin‐Yan, G., et al. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13292 · Cited by 48
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population
Nielsen, J. C., Lin, Y., Figueiredo, M. J. D. O., Shamloo, A. S., Alfie, A., Bovéda, S., Dagres, N., Toro, D. D., Eckhardt, L. L., Ellenbogen, K. A., et al. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.05.004 · Cited by 42
Self-citation
Atrial fibrillation in inherited cardiac channelopathies: From mechanisms to management.
Enriquez, A., Antzelevitch, C., Bismah, V., & Baranchuk, A. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.06.008 · Cited by 38
Ranolazine: An Old Drug with Emerging Potential; Lessons from Pre-Clinical and Clinical Investigations for Possible Repositioning
Rouhana, S., Virsolvy, A., Farès, N., Richard, S., & Thireau, J. (2021) · Pharmaceuticals · doi:10.3390/ph15010031 · Cited by 40
Targeted pharmacological reversal of electrical remodeling after cardioversion—Rationale and design of the Flecainide Short-Long (Flec-SL) trial
Kirchhof, P. F., Fetsch, T., Hanrath, P., Meinertz, T., Steinbeck, G., Lehmacher, W., & BREITHARDT, G. E. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.07.020 · Cited by 34
Self-citation
IKs Gain‐ and Loss‐of‐Function in Early‐Onset Lone Atrial Fibrillation
Steffensen, A. B., Refsgaard, L., Andersen, M. N., Vallet, C., Mujezinovic, A., Haunsø, S., Svendsen, J. H., Olesen, S., OLESEN, M. S., & Schmitt, N. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12666 · Cited by 32
Frontal QRS-T Angle and the Risk of Atrial Fibrillation in the Elderly
Jogu, H. R., O’Neal, W. T., Broughton, S. T., Shah, A. J., Zhang, Z., & Soliman, E. Z. (2016) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12388 · Cited by 31
Hypocalcaemia, long QT interval and atrial arrhythmias
Nijjer, S. S., Ghosh, A. K., & Dubrey, S. W. (2010) · BMJ Case Reports · doi:10.1136/bcr.08.2009.2216 · Cited by 29
Novel pharmacological targets for the rhythm control management of atrial fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.08.002 · Cited by 31
Prolonged QTc Interval Predicts Poststroke Paroxysmal Atrial Fibrillation
Hoshino, T., Nagao, T., Shiga, T., Maruyama, K., Toi, S., Mizuno, S., Ishizuka, K., Shimizu, S., Uchiyama, S., & Kitagawa, K. (2014) · Stroke · doi:10.1161/strokeaha.114.006612 · Cited by 26
Paediatric/young versus adult patients with long QT syndrome
Lee, S., Zhou, J., Jeevaratnam, K., Wong, W. T., Wong, I. C. K., Mak, C. M., Mok, N. S., Liu, T., Zhang, Q., & Tse, G. (2021) · Open Heart · doi:10.1136/openhrt-2021-001671 · Cited by 27
Electrophysiological effects of flecainide and sotalol in the human atrium during persistent atrial fibrillation
Kirchhof, P. F., Engelen, M. A., Franz, M. R., Ribbing, M., Wasmer, K., BREITHARDT, G. E., Haverkamp, W., & Eckardt, L. (2005) · Basic Research in Cardiology · doi:10.1007/s00395-005-0513-4 · Cited by 26
Self-citation
Electrocardiographic Predictors of Incident Atrial Fibrillation
Nguyen, K. T., Vittinghoff, E., Dewland, T. A., Mandyam, M. C., Stein, P. K., Soliman, E. Z., Heckbert, S. R., & Marcus, G. M. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.06.008 · Cited by 25
Action potential shortening rescues atrial calcium alternans
Kanaporis, G., Kalik, Z. M., & Blatter, L. A. (2018) · The Journal of Physiology · doi:10.1113/jp277188 · Cited by 23
Ion channels, long QT syndrome and arrhythmogenesis in ageing
Jeevaratnam, K., Chadda, K. R., Salvage, S. C., Valli, H., Ahmad, S., Grace, A. A., & Huang, C. L.-H. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12721 · Cited by 20
Characterization of the Genetic Program Linked to the Development of Atrial Fibrillation in CREM-IbΔC-X Mice
Seidl, M. D., Stein, J., Hamer, S., Pluteanu, F., Scholz, B., Wardelmann, E., Huge, A., Witten, A., Stoll, M., Hammer, E., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005075 · Cited by 20
Electrocardiographic Predictors of Atrial Fibrillation
Chousou, P. A., Chattopadhyay, R. K., Tsampasian, V., Vassiliou, V. S., & Pugh, P. J. (2023) · Medical Sciences · doi:10.3390/medsci11020030 · Cited by 25
Atrial arrhythmogenesis in wild-type and Scn5a+/Δ murine hearts modelling LQT3 syndrome
Dautova, Y., Zhang, Y., Sabir, I. N., Grace, A. A., & Huang, C. L.-H. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0633-z · Cited by 19
The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease
Weigl, I., Geschwill, P., Reiss, M., Bruehl, C., Draguhn, A., Koenen, M., Sedaghat‐Hamedani, F., Meder, B., Thomas, D., Katus, H. A., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.150 · Cited by 19
Human Induced Pluripotent Stem Cell as a Disease Modeling and Drug Development Platform—A Cardiac Perspective
Bekhite, M. M., & Schulze, P. C. (2021) · Cells · doi:10.3390/cells10123483 · Cited by 21
Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome
Yaman, M. M. E., Perry, J. C., Makielski, J. C., & Ackerman, M. J. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.10.029 · Cited by 16
Atrial Remodeling and Novel Pharmacological Strategies for Antiarrhythmic Therapy in Atrial Fibrillation
Jost, N., Kohajda, Z., Kristóf, A., Husti, Z., Juhász, V., Kiss, L., Varró, A., Virág, L., & Baczkó, I. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711796642373 · Cited by 16
Effect of Electrode Position on the Outcome of Cardioversion
Kirchhof, P. F., Borggrefe, M., & BREITHARDT, G. E. (2003) · Cardiac Electrophysiology Review · doi:10.1023/b:cepr.0000012399.96959.ab · Cited by 16
Self-citation
Atrial Arrhythmias in the Inherited Long QT Syndrome:
Vincent, G. M. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.03365.x · Cited by 14
Genetic Polymorphism of KCNH2 Confers Predisposition of Acquired Atrial Fibrillation in Chinese
WANG, Q., WANG, X., Chen, X., YU, J., Wang, J., Sun, J., Lu, S.-B., SHEN, M., Lu, M., Li, Y., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01494.x · Cited by 14
The QT Interval as a Noninvasive Marker of Atrial Refractoriness
Nguyen, K. T., Gladstone, R. A., Dukes, J. W., Nazer, B., Vittinghoff, E., Badhwar, N., Vedantham, V., Gerstenfeld, E. P., Lee, B. K., Lee, R. J., et al. (2016) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12962 · Cited by 13
Paediatric/young versus adult patients with congenital long QT syndrome or catecholaminergic polymorphic ventricular tachycardia
Lee, S., Zhou, J., Jeevaratnam, K., Lakhani, I., Wong, W. T., Wong, I. C. K., Mak, C. M., Mok, N. S., Liu, T., Zhang, Q., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab724.1870 · Cited by 12
The German Competence Network on Atrial Fibrillation (AFNET)
Breithardt, G., Dobrev, D., Doll, N., Goette, A., Hoffmann, B. A., Kirchhof, P. F., Köster, I., Kück, K., Leute, A., Meinertz, T., et al. (2008) · Herz · doi:10.1007/s00059-008-3177-2 · Cited by 12
Self-citation
The association of QT interval components with atrial fibrillation
Patel, N. N., O’Neal, W. T., Whalen, S. P., & Soliman, E. Z. (2017) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12467 · Cited by 11
Atrial Fibrillation in Inherited Channelopathies
Al-Azzam, B., & Darbar, D. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.10.004 · Cited by 11
Frontal plane QRS-T angle may be a predictor for post-coronary artery bypass graft surgery atrial fibrillation
Kuyumcu, M. S., Uysal, D., Özbay, M. B., Aydın, O., & İbrişim, E. (2020) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.66.12.1673 · Cited by 9
Electrocardiographic intervals associated with incident atrial fibrillation: Dissecting the QT interval
Roberts, J. D., Soliman, E. Z., Alonso, Á., Vittinghoff, E., Chen, L. Y., Loehr, L. R., & Marcus, G. M. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.02.005 · Cited by 8
Pauses after burst pacing provoke afterdepolarizations and torsades de pointes in a patient with long QT syndrome
Kirchhof, P. F., Zellerhoff, S., Mönnig, G., & Schulze‐Bahr, E. (2004) · Heart Rhythm · doi:10.1016/j.hrthm.2004.08.016 · Cited by 8
Self-citation
QTc interval predicts outcome of catheter ablation in paroxysmal atrial fibrillation patients with type 2 diabetes mellitus
Ma, N., Wu, X., Ma, C., Liu, N., Bai, R., Du, X., Ruan, Y., & Dong, J. (2016) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-016-1640-5 · Cited by 8
Atrial flutter and fibrillation in the young patient without congenital heart disease
Abadir, S., Fournier, A., Dubuc, M., & Khairy, P. (2013) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2012.11.006 · Cited by 7
Long QT genetics manifesting as atrial fibrillation
Guerrier, K., Czosek, R. J., Spar, D. S., & Anderson, J. B. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.07.012 · Cited by 7
SCN5A mutations in atrial fibrillation
Amin, A. S., & Bhuiyan, Z. A. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.09.012 · Cited by 7
Atrial arrhythmias in inherited arrhythmogenic disorders
Hasdemir, C. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2015.11.007 · Cited by 7
Inward Rectifier K + Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM‐IbΔC‐X
Pluteanu, F., Seidl, M. D., Hamer, S., Scholz, B., & Müller, F. U. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.016144 · Cited by 6
Systems approaches to post-operative atrial fibrillation — Do they help us to better understand the ionic basis of the arrhythmogenic substrate?
Heijman, J., & Dobrev, D. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.06.005 · Cited by 6
Frontal plane QRS‐T angle predicts early recurrence of acute atrial fibrillation after successful pharmacological cardioversion with intravenous amiodarone
Eyüboğlu, M., & Çelik, A. (2021) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13529 · Cited by 5
The year in electrophysiology
Zipes, D. P. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.01.027 · Cited by 5
The Atrial Phenotype of the Inherited Primary Arrhythmia Syndromes
Conte, G., Schotten, U., & Auricchio, A. (2019) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2019.4.2 · Cited by 4
Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel
Wei, M., Wang, P., Zhu, X., Morishima, M., Liu, Y., Zheng, M., Liu, G., Osanai, H., Yoshimura, K., Kume, S., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280656 · Cited by 4
Effect of autonomic influences to induce triggered activity in muscular sleeves extending into the coronary sinus of the canine heart and its suppression by ranolazine
Sicouri, S., Belardinelli, L., & Antzelevitch, C. N. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13770 · Cited by 4
“Atrial torsades de pointes” in the long QT syndrome
Seslar, S. P., Shepard, S. M., & Berul, C. I. (2008) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9328-9 · Cited by 4
A family of hereditary long QT syndrome caused by Q738X HERG mutation
Yasuda, S., Hiramatsu, S.-I., Odashiro, K., Maruyama, T., Tsuji, K., & Horie, M. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.12.053 · Cited by 4
QTc interval prolongation and risk of atrial fibrillation recurrence: a meta-analysis and observational cohort study
Ding, Q., Wang, Z., Lu, L., Song, Z., Ge, M., & Zhou, Q. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1483591 · Cited by 3
Hypocalcemia: A Little Known Cause of Supraventricular Tachyarrhythmia
Khalid, S., Albaba, I., & Neu, K. (2023) · Cureus · doi:10.7759/cureus.38456 · Cited by 3
Endpunkte für Studien bei Patienten mit Vorhofflimmern
Kirchhof, P. F., Goette, A., Hindricks, G., Hohnloser, S., Kück, K., Meinertz, T., Ravens, U., Steinbeck, G., & Breithardt, G. (2007) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-007-0581-x · Cited by 3
Self-citation
Das Kompetenznetz Vorhofflimmern (AFNET)
Leute, A., Kirchhof, P. F., BREITHARDT, G. E., Goette, A., Lewalter, T., Meinertz, T., Oeff, M., Ravens, U., Steinbeck, G., & Weiß, T. (2006) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-006-1096-7 · Cited by 3
Self-citation
[Atrial fibrillation in the long QT syndrome].
Zienciuk‐Krajka, A., Szwoch, M., & Raczak, G. (2009) · PubMed · Cited by 3
Activation of Small Conductance Ca2+-Activated K+ Channels Suppresses Electrical and Calcium Alternans in Atrial Myocytes
Kanaporis, G., & Blatter, L. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083597 · Cited by 2
Do genetics help to better understand the underlying mechanisms of atrial fibrillation?
Dobrev, D. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl076 · Cited by 2

Authors: KIRCHHOF, P., ECKARDT, L., FRANZ, M. R., MÖNNIG, G., LOH, P., WEDEKIND, H., SCHULZE‐BAHR, E., BREITHARDT, G., & HAVERKAMP, W.
Affiliations: University of Münster (DE)
Georgetown University (US)
Corresponding author: KIRCHHOF, PAULUS
ORCID: KIRCHHOF, PAULUS
ECKARDT, LARS
FRANZ, MICHAEL R.
LOH, PETER
SCHULZE‐BAHR, ERIC
BREITHARDT, GÜNTER
HAVERKAMP, WILHELM
Venue: Journal of Cardiovascular Electrophysiology
Publisher: Wiley
Published: 2003-09-19
Volume: 14
Issue: 10
Pages: 1027-1033
ISSN: 1045-3873 (ISSN-L)
1540-8167
DOI: 10.1046/j.1540-8167.2003.03165.x
OpenAlex: W2089858939
Cited by: 124
References: 34
Citations by year: 2026: 3 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 14 · 2015: 1 · 2014: 1 · 2013: 6 · 2012: 4
FWCI: 3.73
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cardiovascular Electrophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: long QT syndrome, atrial action potential duration, atrial fibrillation, atrial repolarization, effective refractory period, KCNQ1, afterdepolarizations, electrical restitution, monophasic action potential, atrial electrophysiology, torsades de pointes
MeSH terms: Action Potentials, Adolescent, Adult, Atrial Fibrillation, Electrocardiography, Female, Heart Atria, Heart Conduction System, Humans, Long QT Syndrome, Male, Middle Aged, Polymorphism, Genetic, Tachycardia, Ectopic Atrial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prolonged Atrial Action Potential Durations and Polymorphic Atrial Tachyarrhythmias in Patients with Long QT Syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks