Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

Sodium/Calcium Exchange: Its Physiological Implications

Blaustein, M. P., & Lederer, W. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.3.763 · Cited by 1,736 · see citing works

Excitation-Contraction Coupling and Cardiac Contractile Force

Bers, D. M., & Zhu, Y. (2010) · Journal of Cardiovascular Disease Research · doi:10.1016/s0975-3583(10)11011-0 · Cited by 1,606 · see citing works

Excitation-Contraction Coupling and Cardiac Contractile Force

Bers, D. M. (2001) · Developments in cardiovascular medicine · doi:10.1007/978-94-010-0658-3 · Cited by 1,543 · see citing works

Molecular and Cellular Mechanisms of Cardiac Arrhythmias

Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,003 · see citing works

Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.

Bennett, V., & Baines, A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 993 · see citing works

Excitation-Contraction Coupling and Cardiac Contractile Force

Bers, D. M. (1993) · Developments in cardiovascular medicine · doi:10.1007/978-94-017-1512-6 · Cited by 777 · see citing works

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

Gomez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758 · see citing works

Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.

Kass, R. S., Lederer, W. J., Tsien, R. W., & Weingart, R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012416 · Cited by 633 · see citing works

AnkyrinG Is Required for Clustering of Voltage-gated Na Channels at Axon Initial Segments and for Normal Action Potential Firing

Zhou, D., Lambert, S., Malen, P. L., Carpenter, S., Boland, L. M., & Bennett, V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1295 · Cited by 568 · see citing works

Sodium-Calcium Exchange: A Molecular Perspective

Philipson, K. D., & Nicoll, D. A. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.111 · Cited by 540 · see citing works

Measurement of heart rate and Q-T interval in the conscious mouse

Mitchell, G. F., Jeron, A., & Koren, G. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.3.h747 · Cited by 539 · see citing works

Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

Jenkins, S. M., & Bennett, V. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200109026 · Cited by 446 · see citing works

Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a

Papadatos, G., Wallerstein, P. M. R., Head, C., Ratcliff, R. A., Brady, P. A., Benndorf, K., Saumarez, R. C., Trezise, A. E. O., Huang, C. L.-H., Vandenberg, J. I., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082121299 · Cited by 386 · see citing works

Mapping of a gene for long QT syndrome to chromosome 4q25-27.

Schott, J., Charpentier, F., Peltier, S., Foley, P., Drouin, E., Bouhour, J. B., Donnelly, P., Vergnaud, G., Bachner, L., & Moisan, J. (1995) · Europe PMC (PubMed Central) · Cited by 353 · see citing works

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange– Nielsen Syndrome

Casimiro, M. C., Knollmann, B. C., Ebert, S. N., Vary, J. C., Greene, A. E., Franz, M. R., Grinberg, A., Huang, S. P., & Pfeifer, K. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041398998 · Cited by 260 · see citing works

In Vivo Cardiac Electrophysiology Studies in the Mouse

Berul, C. I., Aronovitz, M. J., Wang, P. J., & Mendelsohn, M. E. (1996) · Circulation · doi:10.1161/01.cir.94.10.2641 · Cited by 229 · see citing works

Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia

Marks, A. R., Priori, S. G., Memmi, M., KONTULA, K. K., & Laitinen-Forsblom, P. J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.10031 · Cited by 205 · see citing works

Afterdepolarizations and triggered activity

Fozzard, H. A. (1992) · Steinkopff eBooks · doi:10.1007/978-3-642-72477-0_10 · Cited by 200 · see citing works

Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons

Scotland, P., Zhou, D., Benveniste, H., & Bennett, V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1305 · Cited by 185 · see citing works

The Na + -Ca 2+ Exchanger Is Essential for the Action of Cardiac Glycosides

Reuter, H., Henderson, S. A., Han, T.-Y., Ross, R. S., Goldhaber, J. I., & Philipson, K. D. (2002) · Circulation Research · doi:10.1161/hh0302.104562 · Cited by 179 · see citing works

Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel

London, B., Jeron, A., Zhou, J., Buckett, P. D., Han, X., Mitchell, G. F., & Koren, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2926 · Cited by 173 · see citing works

Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance

Santana, L. F., Gomez, A. M., & Lederer, W. J. (1998) · Science · doi:10.1126/science.279.5353.1027 · Cited by 166 · see citing works

The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells.

Bourguignon, L., Jin, H., Iida, N., Brandt, N. R., & Zhang, S. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53175-6 · Cited by 165 · see citing works

Calcium Sparks and Excitation–Contraction Coupling in Phospholamban‐Deficient Mouse Ventricular Myocytes

Santana, L. F., Kranias, E. G., & Lederer, W. J. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.021bi.x · Cited by 142 · see citing works

Ankyrin-B Is Required for Intracellular Sorting of Structurally Diverse Ca2+ Homeostasis Proteins

Tuvia, S., Buhusi, M., Davis, L., Reedy, M., & Bennett, V. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.995 · Cited by 127 · see citing works

Molecular biology and the prolonged QT syndromes

Towbin, J. A., & Vatta, M. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00715-4 · Cited by 113 · see citing works

The Ankyrin-B C-terminal Domain Determines Activity of Ankyrin-B/G Chimeras in Rescue of Abnormal Inositol 1,4,5-Trisphosphate and Ryanodine Receptor Distribution in Ankyrin-B (−/−) Neonatal Cardiomyocytes

Mohler, P. J., Gramolini, A. O., & Bennett, V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110958200 · Cited by 113 · see citing works

Dynamic modulation of excitation‐contraction coupling by protein phosphatases in rat ventricular myocytes.

duBell, W. H., Lederer, W. J., & Rogers, T. B. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021423 · Cited by 86 · see citing works

Ankyrins

Mohler, P. J., Gramolini, A. O., & Bennett, V. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1565 · Cited by 71 · see citing works

Transgenic mice overexpressing human KvLQT1 dominant-negative isoform Part II: Pharmacological profile

Lande, G. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00232-2 · Cited by 37 · see citing works

Heterozygous VMAT2 knockout mice display prolonged QT intervals: possible contributions to sudden death

Itokawa, K., Sora, I., Schindler, C. W., Itokawa, M., Takahashi, N., & Uhl, G. R. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00194-1 · Cited by 27 · see citing works

Plasminogen activator inhibitor-1 in cardiovascular cells: rapid induction after injecting mice with kainate or adrenergic agents

Venugopal, B. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00271-6 · Cited by 25 · see citing works

Differential effects of adrenaline and noradrenaline on the hepatic expression of immediate early genes in mice

Im, Y., Won, J., Suh, H., Huh, S., Kim, Y., & Song, D. ‐. (1998) · Journal of Autonomic Pharmacology · doi:10.1046/j.1365-2680.1998.1830149.x · Cited by 15 · see citing works

Immunologicalization and Structural Configuration of Membrane and Cytoskeletal Proteins Involved in Excitation-Contraction Coupling of Cardiac Muscle

Frank, J. S., & Garfinkel, A. (1997) · Elsevier eBooks · doi:10.1016/b978-012436570-4/50003-0 · Cited by 2 · see citing works

Drug-induced prolongation of the QT interval

Roden, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032426 · Cited by 1,965 · see citing works

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Myerburg, R. J., Quiñones, M. A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.010 · Cited by 1,963 · see citing works

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten‐Jacobs, L. C. A., Giese, A., van der Laan, S. W., Grétarsdóttir, S., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0058-3 · Cited by 1,566 · see citing works

Inositol Trisphosphate Receptor Ca²⁺Release Channels

Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188 · see citing works

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): <i>Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society</i>

Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178233 · Cited by 1,080 · see citing works

Molecular Physiology of Cardiac Repolarization

Nerbonne, J. M., & Kass, R. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00002.2005 · Cited by 1,054 · see citing works

FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death

Wehrens, X. H. T., Lehnart, S. E., Huang, F., Vest, J. A., Reiken, S. R., Mohler, P. J., Sun, J., Guatimosim, S., Song, L., Rosemblit, N., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00434-3 · Cited by 760 · see citing works

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Moss, A. J., Myerburg, R. J., et al. (2006) · EP Europace · doi:10.1093/europace/eul108 · Cited by 735 · see citing works

Sudden Cardiac Death Prediction and Prevention

Fishman, G. I., Chugh, S. S., Dimarco, J., Albert, C. M., Anderson, M. E., Bonow, R. O., Buxton, A. E., Chen, P., Estes, M., Jouven, X., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.976092 · Cited by 609 · see citing works

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing

Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2005.01.020 · Cited by 560 · see citing works

Mutant Caveolin-3 Induces Persistent Late Sodium Current and Is Associated With Long-QT Syndrome

Vatta, M., Ackerman, M. J., Ye, B., Makielski, J. C., Ughanze, E. E., Taylor, E. W., Tester, D. J., Balijepalli, R. C., Foell, J. D., Li, Z., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.635268 · Cited by 554 · see citing works

Recent advances in the molecular pathophysiology of atrial fibrillation

Wakili, R., Voigt, N., Kääb, S., Dobrev, D., & Nattel, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46315 · Cited by 543 · see citing works

Mechanisms of sudden cardiac death

Rubart, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26381 · Cited by 503 · see citing works

Protection from Cardiac Arrhythmia Through Ryanodine Receptor-Stabilizing Protein Calstabin2

Wehrens, X. H. T., Lehnart, S. E., Reiken, S. R., Deng, S., Vest, J. A., Cervantes, D. O., Coromilas, J., Landry, D. W., & Marks, A. R. (2004) · Science · doi:10.1126/science.1094301 · Cited by 482 · see citing works

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

Kozyrev, S. V., Abelson, A.-K., Wojcik, J., Zaghlool, A., Reddy, M., Sánchez, E., Gunnarsson, I., Svenungsson, E., Sturfelt, G. K., Jönsen, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.79 · Cited by 474 · see citing works

Overview of Basic Mechanisms of Cardiac Arrhythmia

Antzelevitch, C. N., & Burashnikov, A. (2011) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2010.10.012 · Cited by 472 · see citing works

Genetic Testing in the Long QT Syndrome

Napolitano, C., Priori, S. G., Schwartz, P. J., Bloise, R., Ronchetti, E., Nastoli, J., Bottelli, G., Cerrone, M., & Leonardi, S. (2005) · JAMA · doi:10.1001/jama.294.23.2975 · Cited by 464 · see citing works

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test

Kapplinger, J. D., Tester, D. J., Salisbury, B. A., Carr, J. L., Harris‐Kerr, C., Pollevick, G. D., Wilde, A. A. M., & Ackerman, M. J. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.05.021 · Cited by 450 · see citing works

Drug-Induced Long QT Syndrome

Kannankeril, P. J., Roden, D. M., & Darbar, D. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003723 · Cited by 441 · see citing works

Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators

Patterson, R. L., Boehning, D. F., & Snyder, S. H. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.161303 · Cited by 438 · see citing works

Mutation in Glycerol-3-Phosphate Dehydrogenase 1–Like Gene ( <i>GPD1-L</i> ) Decreases Cardiac Na ⁺ Current and Causes Inherited Arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.703330 · Cited by 437 · see citing works

The genetic basis of long QT and short QT syndromes: A mutation update

Hedley, P. L., Jørgensen, P., Schlamowitz, S., Wangari, R., Moolman‐Smook, J. C., Brink, P. A., Kanters, J. K., Corfield, V. A., & Christiansen, M. (2009) · Human Mutation · doi:10.1002/humu.21106 · Cited by 422 · see citing works

Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families

Behr, E. R., Dalageorgou, C., Christiansen, M., Syrris, P., Hughes, S., Tome, M., Rowland, E., Jeffery, S., & McKenna, W. J. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn219 · Cited by 417 · see citing works

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

Lehnart, S. E., Mongillo, M., Bellinger, A. M., Lindegger, N., Chen, B.-X., HSUEH, W. H., Reiken, S. R., Wronska, A., Drew, L., Ward, C. W., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35346 · Cited by 413 · see citing works

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases

Wilde, A. A. M., Semsarian, C., Márquez, M. F., Shamloo, A. S., Ackerman, M. J., Ashley, E. A., Sternick, E. B., Barajas-Martínez, H., Behr, E. R., Bezzina, C. R., et al. (2022) · EP Europace · doi:10.1093/europace/euac030 · Cited by 399 · see citing works

Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement

Brugada, J., Blom, N. A., Sarquella‐Brugada, G., Blomström‐Lundqvist, C., Deanfield, J. E., Janoušek, J., Abrams, D. J., Bauersfeld, U., Brugada, R., Drago, F., et al. (2013) · EP Europace · doi:10.1093/europace/eut082 · Cited by 397 · see citing works

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

Wilke, R. A., Lin, D. W., Roden, D. M., Watkins, P. B., Flockhart, D. A., Zineh, I., Giacomini, K. M., & Krauss, R. M. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2423 · Cited by 394 · see citing works

An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome

Adler, A., Novelli, V., Amin, A. S., Abiusi, E., Care, M. E., Nannenberg, E. A., Feilotter, H. E., Amenta, S., Mazzà, D., Bikker, H., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043132 · Cited by 391 · see citing works

Identification of a KCNE2 Gain-of-Function Mutation in Patients with Familial Atrial Fibrillation

Yang, Y., Xia, M., Jin, Q., Bendahhou, S., Shi, J., Chen, Y., Liang, B., Lin, J., Liu, Y., Liu, B., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425342 · Cited by 388 · see citing works

FXYD proteins: new regulators of Na-K-ATPase

Geering, K. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00126.2005 · Cited by 372 · see citing works

Na v 1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Na v 1.5 on the surface of cardiomyocytes

Mohler, P. J., Rivolta, I., Napolitano, C., Lemaillet, G., Lambert, S., Priori, S. G., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403711101 · Cited by 359 · see citing works

Postmortem Long QT Syndrome Genetic Testing for Sudden Unexplained Death in the Young

Tester, D. J., & Ackerman, M. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.010 · Cited by 355 · see citing works

Calcium and Arrhythmogenesis

ter Keurs, H. E. D. J., & Boyden, P. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00011.2006 · Cited by 353 · see citing works

Genetic Testing for Long-QT Syndrome

Kapa, S., Tester, D. J., Salisbury, B. A., Harris‐Kerr, C., Pungliya, M. S., Alders, M. M., Wilde, A. A. M., & Ackerman, M. J. (2009) · Circulation · doi:10.1161/circulationaha.109.863076 · Cited by 345 · see citing works

Drug‐Induced Torsades de Pointes and Implications for Drug Development

Fenichel, R. R., Malík, M., Antzelevitch, C. N., Sanguinetti, M. C., Roden, D. M., Priori, S. G., Ruskin, J. N., Lipicky, R. J., Cantilena, L. R., & Independent Academic Task Force (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.03534.x · Cited by 343 · see citing works

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

Mohler, P. J., Splawski, I., Napolitano, C., Bottelli, G., Sharpe, L. M., Timothy, K. W., Priori, S. G., Keating, M. T., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402546101 · Cited by 323 · see citing works

The WAVE regulatory complex links diverse receptors to the actin cytoskeleton

Chen, B., Brinkmann, K., Chen, Z., Pak, C. W., Liao, Y., Shi, S., Henry, L., Grishin, N. V., Bogdan, S., & Rosen, M. K. (2014) · Cell · doi:10.1016/j.cell.2013.11.048 · Cited by 323 · see citing works

Congenital long QT syndrome

Crotti, L., Celano, G., Dagradi, F., & Schwartz, P. J. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-18 · Cited by 311 · see citing works

The QT syndromes: long and short

Morita, H., Wu, J., & Zipes, D. P. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61307-0 · Cited by 311 · see citing works

Predicting drug–hERG channel interactions that cause acquired long QT syndrome

Sanguinetti, M. C., & Mitcheson, J. S. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.01.003 · Cited by 300 · see citing works

The cytoskeleton, cellular motility and the reductionist agenda

Pollard, T. D. (2003) · Nature · doi:10.1038/nature01598 · Cited by 300 · see citing works

Ethnic Differences in Cardiac Potassium Channel Variants: Implications for Genetic Susceptibility to Sudden Cardiac Death and Genetic Testing for Congenital Long QT Syndrome

Ackerman, M. J., Tester, D. J., Jones, G. S., Will, M. L., Burrow, C. R., & Curran, M. E. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1479 · Cited by 295 · see citing works

Long QT syndrome: from channels to cardiac arrhythmias

Moss, A. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25537 · Cited by 293 · see citing works

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

Hólm, H., Gudbjartsson, D. F., Sulem, P., Másson, G., Helgadottir, H. T., Zanon, C., Magnússon, Ó. Þ., Helgason, A., Saemundsdottir, J., Gylfason, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.781 · Cited by 293 · see citing works

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy

Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M., & Ackerman, M. J. (2008) · Neurology · doi:10.1212/01.wnl.0000335760.02995.ca · Cited by 281 · see citing works

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the State of Genetic Testing for Cardiac Diseases

Wilde, A. A. M., Semsarian, C., Márquez, M. F., Shamloo, A. S., Ackerman, M. J., Ashley, E. A., Sternick, E. B., Barajas-Martínez, H., Behr, E. R., Bezzina, C. R., et al. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2022.03.1225 · Cited by 281 · see citing works

miR-1 Overexpression Enhances Ca 2+ Release and Promotes Cardiac Arrhythmogenesis by Targeting PP2A Regulatory Subunit B56α and Causing CaMKII-Dependent Hyperphosphorylation of RyR2

Terentyev, D. A., Belevych, A. E., Terentyeva, R., Martin, M. M., Malana, G. E., Kuhn, D. E., Abdellatif, M., Feldman, D. S., Elton, T. S., & Györke, S. (2009) · Circulation Research · doi:10.1161/circresaha.108.181651 · Cited by 279 · see citing works

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1 , and KCNE2 in drug-induced long QT syndrome patients

Paulussen, A. D. C., Gilissen, R. A. H. J., Armstrong, M., Doevendans, P. A., Verhasselt, P., Smeets, H. J. M., Schulze‐Bahr, E., Haverkamp, W., Breithardt, G., Cohen, N., et al. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0522-z · Cited by 279 · see citing works

Spectrum and Frequency of Cardiac Channel Defects in Swimming-Triggered Arrhythmia Syndromes

Choi, G. R., Kopplin, L. J., Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2004) · Circulation · doi:10.1161/01.cir.0000144471.98080.ca · Cited by 271 · see citing works

Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias

Ouvrard‐Pascaud, A., Sainte–Marie, Y., Bénitah, J., Perrier, R., Soukaseum, C., Cat, A. N. D., Royer, A., Quang, K. L., Charpentier, F., Demolombe, S., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.503706 · Cited by 271 · see citing works

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

Abriel, H. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.08.025 · Cited by 268 · see citing works

Modulation of Cardiac Gap Junction Expression and Arrhythmic Susceptibility

Danik, S. B., Liu, F., Zhang, J., Suk, H. J., Morley, G. E., Fishman, G. I., & Gutstein, D. E. (2004) · Circulation Research · doi:10.1161/01.res.0000148664.33695.2a · Cited by 268 · see citing works

Physicochemical Features of the hERG Channel Drug Binding Site

Fernández, D., Ghanta, A., Kauffman, G. W., & Sanguinetti, M. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310683200 · Cited by 267 · see citing works

Muscle KATPChannels: Recent Insights to Energy Sensing and Myoprotection

Flagg, T. P., Enkvetchakul, D., Koster, J. C., & Nichols, C. G. (2010) · Physiological Reviews · doi:10.1152/physrev.00027.2009 · Cited by 264 · see citing works

Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes

Antzelevitch, C. N. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00355.2007 · Cited by 263 · see citing works

The MinK-related peptides

McCrossan, Z. A., & Abbott, G. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.018 · Cited by 254 · see citing works

Inherited Arrhythmias

Lehnart, S. E., Ackerman, M. J., Benson, D. W., Brugada, R., Clancy, C. E., Donahue, J. K., George, A. L., Grant, A. O., Groft, S. C., January, C. T., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.711689 · Cited by 253 · see citing works

Involvement of lipid rafts and caveolae in cardiac ion channel function

Maguy, A., Hébert, T. E., & Nattel, S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.11.013 · Cited by 253 · see citing works

Ankyrin-B Coordinates the Na/K ATPase, Na/Ca Exchanger, and InsP3 Receptor in a Cardiac T-Tubule/SR Microdomain

Mohler, P. J., Davis, J. Q., & Bennett, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030423 · Cited by 244 · see citing works

Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits

Lemaillet, G., Walker, B. J., & Lambert, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303327200 · Cited by 243 · see citing works

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

Smyth, J. W., Hong, T., Gao, D., Vogan, J. M., Jensen, B. C., Fong, T. S., Simpson, P. C., Stainier, D. Y. R., Chi, N. C., & Shaw, R. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39740 · Cited by 243 · see citing works

A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

Hund, T. J., Koval, O. M., Li, J., Wright, P. J., Qian, L., Snyder, J. S., Gudmundsson, H., Kline, C. F., Davidson, N. P., Cardona, N., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43621 · Cited by 243 · see citing works

Sema3a maintains normal heart rhythm through sympathetic innervation patterning

Ieda, M., Kanazawa, H., Kimura, K., Hattori, F., Ieda, Y., Taniguchi, M., Lee, J.-K., Matsumura, K., Tomita, Y., Miyoshi, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1570 · Cited by 242 · see citing works

The congenital long QT syndromes from genotype to phenotype: clinical implications

Schwartz, P. J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01583.x · Cited by 236 · see citing works

QTc: how long is too long?

Johnson, J. N., & Ackerman, M. J. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.054734 · Cited by 235 · see citing works

Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3

Cronk, L. B., Ye, B., Kaku, T., Tester, D. J., Vatta, M., Makielski, J. C., & Ackerman, M. J. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.11.030 · Cited by 232 · see citing works

Epinephrine QT Stress Testing in the Evaluation of Congenital Long-QT Syndrome

Vyas, H., Hejlik, J., & Ackerman, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.600445 · Cited by 227 · see citing works

Biology of Cardiac Arrhythmias

Delisle, B. P., Anson, B. D., Rajamani, S., & January, C. T. (2004) · Circulation Research · doi:10.1161/01.res.0000128561.28701.ea · Cited by 227 · see citing works

Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac Arrhythmia

Ueda, K., Nakamura, K., Hayashi, T., Inagaki, N., Takahashi, M., Arimura, T., Morita, H., Higashiuesato, Y., Hirano, Y., Yasunami, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311953200 · Cited by 225 · see citing works

Locus for Atrial Fibrillation Maps to Chromosome 6q14–16

Ellinor, P. T., Shin, J. T., Moore, R. K., Yoerger, D. M., & MacRae, C. A. (2003) · Circulation · doi:10.1161/01.cir.0000077910.80718.49 · Cited by 222 · see citing works

Sinus Node and Atrial Arrhythmias

John, R. M., & Kumar, S. (2016) · Circulation · doi:10.1161/circulationaha.116.018011 · Cited by 219 · see citing works

A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families

Smits, J. P. P., Koopmann, T. T., Wilders, R., Veldkamp, M. W., Opthof, T., Bhuiyan, Z. A., Mannens, M. M. A. M., Balser, J. R., Tan, H. L., & Bezzina, C. R. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.02.024 · Cited by 215 · see citing works

Ion Channels in the Heart

Bartos, D. C., Grandi, E., & Ripplinger, C. M. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140069 · Cited by 215 · see citing works

Predicting disease using genomics

Bell, J. I. (2004) · Nature · doi:10.1038/nature02624 · Cited by 214 · see citing works

Innovative approaches to anti-arrhythmic drug therapy

Nattel, S., & Carlsson, L. G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2112 · Cited by 209 · see citing works

Genetics and genomics of autism spectrum disorder: embracing complexity

De Rubeis, S., & Buxbaum, J. D. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv273 · Cited by 208 · see citing works

Autonomic aspects of arrhythmogenesis: the enduring and the new

Verrier, R. L., & Antzelevitch, C. N. (2003) · Current Opinion in Cardiology · doi:10.1097/00001573-200401000-00003 · Cited by 208 · see citing works

Long QT Syndrome

Goldenberg, I., Zaręba, W., & Moss, A. J. (2008) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2008.07.002 · Cited by 208 · see citing works

Recent advances in understanding sex differences in cardiac repolarization

James, A. F., Choisy, S. C. M., & Hancox, J. C. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.05.010 · Cited by 205 · see citing works

Task Force 7: Arrhythmias

Zipes, D. P., Ackerman, M. J., Estes, N. A. M., Grant, A. O., Myerburg, R. J., & Hare, G. F. V. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.014 · Cited by 205 · see citing works

Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

Yang, Y., Yang, Y., Liang, B., Liu, J., Li, J., Grunnet, M., Olesen, S., Rasmussen, H. B., Ellinor, P. T., Gao, L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.04.017 · Cited by 199 · see citing works

Molecular Basis of Arrhythmias

Shah, M. H., Akar, F. G., & Tomaselli, G. F. (2005) · Circulation · doi:10.1161/circulationaha.104.494476 · Cited by 191 · see citing works

Cardiac T-Tubule Microanatomy and Function

Hong, T., & Shaw, R. M. (2016) · Physiological Reviews · doi:10.1152/physrev.00037.2015 · Cited by 191 · see citing works

Membrane Domains Based on Ankyrin and Spectrin Associated with Cell-Cell InteractionsPreprint

Bennett, V., & Healy, J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003012 · Cited by 191 · see citing works

Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes

Kockskämper, J., Zima, A. V., Roderick, H. L., Pieske, B. M., Blatter, L. A., & Bootman, M. D. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.05.014 · Cited by 186 · see citing works

Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes

Antzelevitch, C. N. (2007) · EP Europace · doi:10.1093/europace/eum166 · Cited by 186 · see citing works

Effect of Clinical Phenotype on Yield of Long QT Syndrome Genetic Testing

Tester, D. J., Will, M. L., Haglund, C. M., & Ackerman, M. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.056 · Cited by 184 · see citing works

Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin

Bennett, V., & Healy, J. A. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.11.005 · Cited by 184 · see citing works

Multifocal Ectopic Purkinje-Related Premature Contractions

Laurent, G., Saal, S., Amarouch, M., Béziau, D. M., Marsman, R. F. J., Faivre, L. O., Barc, J., Dina, C., Bertaux, G., Barthez, O., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.052 · Cited by 182 · see citing works

Heterogeneity and cardiac arrhythmias: An overview

Antzelevitch, C. N. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.03.036 · Cited by 180 · see citing works

Pathophysiology and pharmacology of the cardiac “late sodium current”

Zaza, A., Belardinelli, L., & Shryock, J. C. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.06.001 · Cited by 177 · see citing works

Sodium channels as macromolecular complexes: Implications for inherited arrhythmia syndromes

Meadows, L. S., & Isom, L. L. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.003 · Cited by 177 · see citing works

KCNQ1 Assembly and Function Is Blocked by Long-QT Syndrome Mutations That Disrupt Interaction With Calmodulin

Ghosh, S., Nunziato, D. A., & Pitt, G. S. (2006) · Circulation Research · doi:10.1161/01.res.0000218863.44140.f2 · Cited by 173 · see citing works

Molecular Pathophysiology of Congenital Long QT Syndrome

Bohnen, M. S., Peng, G., Robey, S., Terrenoire, C., Iyer, V. R., Sampson, K. J., & Kass, R. S. (2016) · Physiological Reviews · doi:10.1152/physrev.00008.2016 · Cited by 173 · see citing works

Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

Lu, Z., Wu, C. C., Jiang, Y., Ballou, L. M., Clausen, C., Cohen, I. S., & Lin, R. Z. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003623 · Cited by 172 · see citing works

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

Scouarnec, S. L., Bhasin, N., Vieyres, C., Hund, T. J., Cunha, S. R., Koval, O. M., Marionneau, C., Chen, B., Wu, Y., Demolombe, S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805500105 · Cited by 170 · see citing works

Voltage-gated Nav channel targeting in the heart requires an ankyrin-G–dependent cellular pathway

Lowe, J. S., Palygin, O., Bhasin, N., Hund, T. J., Boyden, P. A., Shibata, E. F., Anderson, M. E., & Mohler, P. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710107 · Cited by 170 · see citing works

Cardiac Arrest and Sudden Cardiac Death

Myerburg, R. J., & Castellanos, A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00041-x · Cited by 165 · see citing works

Defining the Cellular Phenotype of “Ankyrin-B Syndrome” Variants

Mohler, P. J., Scouarnec, S. L., Denjoy, I., Lowe, J. S., Guicheney, P., Caron, L., Driskell, I. M., Schott, J., NORRIS, K. J., Leenhardt, A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.656512 · Cited by 164 · see citing works

Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies

George, C. H., Jundi, H., Thomas, N. L., Fry, D. L., & Lai, F. A. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.08.115 · Cited by 163 · see citing works

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

Mohler, P. J., Splawski, I., Napolitano, C., Bottelli, G., Sharpe, L. M., Timothy, K. W., Priori, S. G., Keating, M. T., & Bennett, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402546101 · Cited by 323 · see citing works

Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting

Mohler, P. J., & Bennett, V. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000160372.95116.3e · Cited by 66 · see citing works

Ankyrin-B Syndrome: A Case of Sinus Node Dysfunction, Atrial Fibrillation and Prolonged QT in a Young Adult

Robaei, D., Ford, T. J., & Ooi, S. (2014) · Heart Lung and Circulation · doi:10.1016/j.hlc.2014.09.013 · Cited by 15 · see citing works

Defects in Ankyrin-Based Protein Targeting Pathways in Human Arrhythmia

Gudmundsson, H., Jareczek, F. J., & Mohler, P. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-17575-6_25

Cardiac ankyrins in health and disease

Hashemi, S., Hund, T. J., & Mohler, P. J. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.04.010 · Cited by 80 · see citing works