QT Correction Methods in Children and Adolescents
Abstract
Introduction: Accurate determination of the QTc interval has become increasingly important in the assessment of a drug's ability to prolong cardiac repolarization. Previous work suggests the most appropriate correction formula for adults is QTc = QT/RR0.40, but little on correction methods for children and adolescents has been published. Methods and Results: In this study, ECG data were obtained from a meta‐analysis of seven clinical trials for attention deficit/hyperactivity disorder (ADHD) involving 2,288 children and adolescents. The most appropriate formula for children and adolescents included in this database was found to be QTc = QT/RR0.38. Adjustments of the correction factor specifically for males and females of different ages also are reported. Conclusion: QT correction methods developed for adults do not apply to children. As accurate QTc determination plays a larger role in assessing a drug's potential to retard repolarization, use of age‐ and gender‐specific correction formulas becomes more important.
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Measurement of the QTc interval is not without difficulties, and at least six alternative methods of rate correction are available.
“Finally, it should be noted that measurement of the QTc interval is not without difficulties, and at least six alternative methods of rate correction are available [83, 149].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [149]
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- Authors
- WERNICKE, J. F., FARIES, D., BREITUNG, R., & GIROD, D.
- Affiliations
- Eli Lilly (United States) (US)
- Indiana University School of Medicine (US)
- ORCID
- FARIES, DOUGLAS
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2005-01
- Volume
- 16
- Issue
- 1
- Pages
- 76-80
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2131912056
- Cited by
- 47
- References
- 13
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Keywords
- QTc interval, children, adolescents, cardiac repolarization, drug-induced QT prolongation, attention deficit hyperactivity disorder, ECG
- MeSH terms
- Algorithms, Central Nervous System Stimulants, Child, Diagnosis, Computer-Assisted, Electrocardiography, Female, Humans, Long QT Syndrome, Male, Sensitivity and Specificity, Sex Factors, Reproducibility of Results, Attention Deficit and Disruptive Behavior Disorders
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