The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Integrin-mediated signalling through the MAP-kinase pathway
Open accessAbstract
The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK are mediated by differences in ERK signalling dynamics, including magnitude and duration. In vivo, ERK signalling is stimulated by both growth factors and adhesion signals. A model for adhesion-mediated ERK activation is presented. Outputs of the model such as ERK and FAK activation, as well as responses to different ligand densities, are compared with published experimental data. The model then serves as a basis for understanding how adhesion may contribute to ERK signalling through changes in the dynamics of focal adhesion kinase activation. The main parameters influencing ERK are determined through screening analyses and parameter variation. With these parameters, key points in the pathway that give rise to changes in downstream signalling dynamics are identified. In particular, oncogenic Raf and Ras promote cell growth by increasing the magnitude and duration, respectively, of ERK activity.
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“The MAPK/ERK cascade is a key regulator of cell growth and proliferation, but most important, this signaling pathway activates the binding of different integrins at the cell surface to extracellular matrix proteins [60], linking its function with the up-regulated integrin pathway explained above.”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [60]
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Extracellular Vesicle Protein Cargo Reveals Potential Long-Term Biological Impact of Long COVID
Oda, K., Belmonte, A. D., Boulifard, D. A., Jakubski, S., White, L. E., Beckett, C. G., Letizia, A., Porter, C., Villasante, E. F., Johnson, Y. S., et al. (2026) · Cells · doi:10.3390/cells15211969
Metadata
- Authors
- Yee, K. L., Weaver, V. M., & Hammer, D. A.
- Affiliations
- University of Pennsylvania (US)
- University of California, San Francisco (US)
- Venue
- IET Systems Biology
- Published
- 2008-01-21
- Volume
- 2
- Issue
- 1
- Pages
- 8-15
- ISSN
- 1751-8849 (ISSN-L)
- 1751-8857
- OpenAlex
- W2023251706
- Cited by
- 117
- References
- 51
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 4 · 2012: 6
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- repository.upenn.edu
- Locations
- IET Systems Biology (publishedVersion)
- PubMed (publishedVersion)
- ScholarlyCommons (University of Pennsylvania) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- integrin signaling, MAP kinase cascade, ERK activation, focal adhesion kinase, ligand density, oncogenic Ras, cell growth and proliferation
- MeSH terms
- Animals, Humans, Models, Biological, Integrins, ras Proteins, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System
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