Weaver, Valerie M.

The extracellular matrix at a glance

Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 4,334

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 4,101

Tensional homeostasis and the malignant phenotype

Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 3,941

A framework for advancing our understanding of cancer-associated fibroblasts

Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 3,863

The extracellular matrix: A dynamic niche in cancer progression

Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 3,024

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 2,681

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton

Cellular Mechanics and InteractionsForce Microscopy Techniques and Applications

Cited by 2,325

Extracellular Matrix Degradation and Remodeling in Development and Disease

Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011) · Cold Spring Harbor Perspectives in Biology

Protease and Inhibitor MechanismsCellular Mechanics and Interactions

Cited by 2,265

Extracellular Matrix Assembly: A Multiscale Deconstruction

Mouw, J. K., Ou, G., & Weaver, V. M. (2014) · Nature Reviews Molecular Cell Biology

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 1,534

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology

Cell Adhesion Molecules ResearchCellular Mechanics and Interactions

Cited by 1,483

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

Paszek, M. J., DuFort, C. C., Rossier, O., Bainer, R., Mouw, J. K., Godula, K., Hudak, J. E., Lakins, J. N., Wijekoon, A. C., Cassereau, L., et al. (2014) · Nature

Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins Research

Cited by 699

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

Wang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R., & Bissell, M. J. (1998) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchHER2/EGFR in Cancer Research

Cited by 653

The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate

Muncie, J. M., & Weaver, V. M. (2018) · Current Topics in Developmental Biology

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 286

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2015) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchTGF-β signaling in diseases

Cited by 245

Stiff matrix induces exosome secretion to promote tumour growth

Wu, B., Liu, D.-A., Guan, L., Myint, P. K., Chin, L., Dang, H., Xu, Y., Ren, J., Li, T., Yu, Z., et al. (2023) · Nature Cell Biology

Extracellular vesicles in diseaseCellular Mechanics and Interactions

Cited by 240

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

Takai, K., Le, A., Weaver, V. M., & Werb, Z. (2016) · Oncotarget

TGF-β signaling in diseasesCancer Cells and Metastasis

Cited by 207

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha

Desai, S. S., Tung, J. C., Zhou, V. X., Grenert, J. P., Malato, Y., Rezvani, M., Español‐Suñer, R., Willenbring, H., Weaver, V. M., & Chang, T. T. (2016) · Hepatology

Cellular Mechanics and InteractionsLiver physiology and pathology

Cited by 185

Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells

Eliazer, S., Muncie, J. M., Christensen, J., Sun, X., D’Urso, R. S., Weaver, V. M., & Brack, A. S. (2019) · Cell Stem Cell

Muscle Physiology and DisordersHippo pathway signaling and YAP/TAZ

Cited by 171

Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response

Leight, J. L., Drain, A. P., & Weaver, V. M. (2017) · Annual Review of Cancer Biology

Cellular Mechanics and InteractionsHydrogels: synthesis, properties, applications

Cited by 131

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix

Jiang, H., Torphy, R. J., Steiger, K., Hongo, H., Ritchie, A. J., Kriegsmann, M., Horst, D., Umetsu, S. E., Joseph, N. M., McGregor, K., et al. (2020) · Journal of Clinical Investigation

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 127

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., et al. (2020) · Science Translational Medicine

Liver physiology and pathologySphingolipid Metabolism and Signaling

Cited by 122

Integrin-mediated signalling through the MAP-kinase pathway

Yee, K. L., Weaver, V. M., & Hammer, D. A. (2008) · IET Systems Biology

Protein Kinase Regulation and GTPase SignalingCell Adhesion Molecules Research

Cited by 117

Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties

Miroshnikova, Y. A., Jorgens, D. M., Spirio, L., Auer, M., Sarang-Sieminski, A. L., & Weaver, V. M. (2011) · Physical Biology

Cellular Mechanics and InteractionsSupramolecular Self-Assembly in Materials

Cited by 82

Leveraging microenvironmental synthetic lethalities to treat cancer

Metcalf, K. J., Alazzeh, A., Werb, Z., & Weaver, V. M. (2021) · Journal of Clinical Investigation

Cancer Cells and MetastasisCancer Immunotherapy and Biomarkers

Cited by 42