Cited by 119Protein Kinase Regulation and GTPase SignalingCell Adhesion Molecules ResearchGene Regulatory Network Analysis

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Integrin-mediated signalling through the MAP-kinase pathway

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Yee, K.L., Weaver, V.M., Hammer, D.A.·2008·IET Systems Biology

DOI 10.1049/iet-syb:20060058

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Abstract

The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK are mediated by differences in ERK signalling dynamics, including magnitude and duration. In vivo, ERK signalling is stimulated by both growth factors and adhesion signals. A model for adhesion-mediated ERK activation is presented. Outputs of the model such as ERK and FAK activation, as well as responses to different ligand densities, are compared with published experimental data. The model then serves as a basis for understanding how adhesion may contribute to ERK signalling through changes in the dynamics of focal adhesion kinase activation. The main parameters influencing ERK are determined through screening analyses and parameter variation. With these parameters, key points in the pathway that give rise to changes in downstream signalling dynamics are identified. In particular, oncogenic Raf and Ras promote cell growth by increasing the magnitude and duration, respectively, of ERK activity.

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Hanahan, 2000, 100, 57
Aplin, 2001, 155, 187
Shaulian, 2001, 20, 2390
Marshall, 1999, 11, 732
Roovers, 2000, 22, 818
Danen, 2001, 189, 1
Renshaw, 1997, 16, 5592
Barberis, 2000, 275, 36532
Schlaepfer, 1998, 8, 151
Wary, 1996, 87, 733
Assoian, 2001, 11, 48
Giancotti, 1997, 9, 691
Schwartz, 2002, 4, E65
Roovers, 1999, 10, 3197
Kholodenko, 1999, 274, 30169
Schoeberl, 2002, 20, 370
Chapman, 2004, 85, 311
Hornberg, 2005, 24, 5533
Asthagiri, 1999, 274, 27119
Giannone, 2004, 116, 431
Parsons, 2003, 116, 1409
Aplin, 1998, 50, 197
Kaplan, 1994, 13, 4745
Bjorge, 2000, 19, 5620
Boerner, 1996, 35, 9519
Cole, 1994, 269, 30880
Schlaepfer, 1997, 272, 13189
Schlaepfer, 1998, 18, 2571
Downward, 1994, 338, 113
Howe, 1998, 273, 27268
Wary, 1998, 94, 625
Kaneko, 2003, 278, 48162
Matsuda, 1996, 271, 14468
Fincham, 1996, 135, 1551
Wang, 2002, 277, 40428
Wang, 1997, 36, 2993
Zhang, 1995, 270, 11199
Sydor, 1998, 37, 14292
Hecker, 2004, 23, 3962
Sharma, 1998, 17, 271
Sewing, 1997, 17, 5588
Woods, 1997, 17, 5598
Dougherty, 2005, 17, 215
Sundberg-Smith, 2005, 280, 2055
Brummer, 2003, 22, 8823

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Authors: Yee, K. L., Weaver, V. M., & Hammer, D. A.
Affiliations: University of Pennsylvania (US)
University of California, San Francisco (US)
ORCID: Yee, K.L.
Weaver, V.M.
Venue: IET Systems Biology
Publisher: Institution of Engineering and Technology (IET)
Published: 2008-01-21
Volume: 2
Issue: 1
Pages: 8-15
ISSN: 1751-8849 (ISSN-L)
1751-8857
DOI: 10.1049/iet-syb:20060058
OpenAlex: W2023251706
Cited by: 117
References: 51
Citations by year: 2026: 6 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 4 · 2012: 6
FWCI: 0.82
Type: journal article
Language: en
Open access: green
repository.upenn.edu
Locations: IET Systems Biology (publishedVersion)
PubMed (publishedVersion)
ScholarlyCommons (University of Pennsylvania) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords: integrin signaling, MAP kinase cascade, ERK activation, focal adhesion kinase, ligand density, oncogenic Ras, cell growth and proliferation
MeSH terms: Animals, Humans, Models, Biological, Integrins, ras Proteins, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System

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Integrin-mediated signalling through the MAP-kinase pathway

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