Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results
Open accessAbstract
Weaned pigs are susceptible to frequent infectious diseases.Antibiotics have been used over decades to reduce pathogen infections, but many microorganisms are becoming resistant to antibiotics.Thus, there is an urgent need to find alternatives to in-feed antibiotics.Up to now, various compounds have been used as alternatives, giving promising but sometimes contrasting results.In recent years, the in vitro models of cell culture have been proposed for the screening of various compounds and understanding their mechanisms of action.The intestine is a complex system with a continuous cross-talk among epithelial cells, the local immune system and microflora.Alternatives to in-feed antibiotics may interact with any of these constituents.This review presents data on the protective effects of probiotics, zinc salts and organic acids, used as alternatives to in-feed antibiotics, against pathogen induced damage and inflammatory processes in the intestinal cells and the underlying mechanisms, with an attempt to compare in vitro and in vivo results.All the alternatives tested resulted in effective protection against pathogens by a series of interactions with intestinal cells and pathogens, including the inhibition of adhesion and invasion of pathogens, interference in signalling pathways induced by pathogenic bacteria, maintenance of the epithelial cell cytoskeleton and junctional structure and modulation of the host immune response.antibiotic alternative / intestinal cell culture / probiotic / zinc oxide / organic acid Résumé -Alternatives aux antibiotiques additifs alimentaires chez le porc : évaluation des probiotiques, sels de zinc ou acides organiques comme agents protecteurs de la muqueuse intestinale.Comparaison des résultats in vitro avec les observations in vivo.Le porcelet est sensible aux infections gastro-intestinales au moment du sevrage.Les antibiotiques additifs alimentaires ont été utilisés pendant des décennies pour réduire ces infections, mais de nombreux
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The survival of probiotic bacteria in gastrointestinal ecosystems and their adhesion to intestinal mucosa are preconditions for temporary colonization, stimulation of the immune system, and resistance to intestinal pathogens.
“The survival of probiotic bacteria in gastrointestinal ecosystems and their adhesion to intestinal mucosa is considered to be preconditions for temporary colonization, stimulation of the immune system, and resistance to intestinal pathogens (Hudault et al., 1997; Roselli et al., 2005).”
From Adhesion and Colonization of the Probiotic Lactobacillus plantarum HC-2 in the Intestine of Litopenaeus Vannamei Are Associated With Bacterial Surface Proteins (2022) · cites this paper as Roselli et al., 2005
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The biochemical basis of zinc physiology
Vallée, B. L., & Falchuk, K. H. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.79 · Cited by 3,005 · see citing works
Probiotics, prebiotics, and synbiotics—approaching a definition
Schrezenmeir, J., & de Vrese, M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.361s · Cited by 1,519 · see citing works
Sawai, J. (2003) · Journal of Microbiological Methods · doi:10.1016/s0167-7012(03)00037-x · Cited by 992 · see citing works
Bernet‐Camard, M., Brassart, D., Neeser, J., & Servin, A. L. (1994) · Gut · doi:10.1136/gut.35.4.483 · Cited by 751 · see citing works
Organic acids for performance enhancement in pig diets
Partanen, K., & Mroz, Z. (1999) · Nutrition Research Reviews · doi:10.1079/095442299108728884 · Cited by 610 · see citing works
Lallès, J. P., Sève, B., Pié, S., Blazy, F., Laffitte, J., & Oswald, I. P. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.641 · Cited by 587 · see citing works
Rink, L. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000781 · Cited by 587 · see citing works
Mack, D., Michail, S., Wei, S., McDougall, L., & Hollingsworth, M. (1999) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g941 · Cited by 544 · see citing works
IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells
Nusrat, A., Turner, J. R., & Madara, J. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g851 · Cited by 499 · see citing works
Haller, D., Bode, C., Hammes, W. P., Pfeifer, A. M. A., Schiffrin, E. J., & Blum, S. (2000) · Gut · doi:10.1136/gut.47.1.79 · Cited by 466 · see citing works
Immune responses to dietary antigens: oral tolerance
Ströbel, S., & Mowat, A. M. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01239-5 · Cited by 454 · see citing works
Immune System Stimulation by Probiotics
Perdigón, G., Alvarez, S., Rachid, M., Agüero, G., & Gobbato, N. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76784-4 · Cited by 413 · see citing works
Functional modulation of enterocytes by gram-positive and gram-negative microorganisms
Otte, J., & Podolsky, D. K. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2003 · Cited by 403 · see citing works
Overview of Zinc Absorption and Excretion in the Human Gastrointestinal Tract
Krebs, N. F. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1374s · Cited by 395 · see citing works
Gopal, P. K., Prasad, J., Smart, J., & Gill, H. S. (2001) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00440-8 · Cited by 392 · see citing works
Zinc Oxide Protects Cultured Enterocytes from the Damage Induced by Escherichia coli
Roselli, M., Finamore, A., Garaguso, I., Britti, M. S., & Mengheri, E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.12.4077 · Cited by 391 · see citing works
Probiotic immunomodulation in health and disease
Erickson, K. L., & Hubbard, N. E. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.2.403s · Cited by 372 · see citing works
Tight junctions and human diseases
Sawada, N., Murata, M., Kikuchi, K., Osanai, M., Tobioka, H., Kojima, T., & Chiba, H. (2003) · Medical Molecular Morphology · doi:10.1007/s00795-003-0219-y · Cited by 348 · see citing works
DNA from probiotic bacteria modulates murine and human epithelial and immune function
Jijon, H. B., Backer, J., Díaz, H., Yeung, H. P., Thiel, D., McKaigney, C. J., Simone, C. D., & Madsen, K. L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.003 · Cited by 318 · see citing works
Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model
Mattar, A., Teitelbaum, D. H., Drongowski, R. A., Fan, Y., Harmon, C. M., & Coran, A. G. (2002) · Pediatric Surgery International · doi:10.1007/s00383-002-0855-7 · Cited by 309 · see citing works
N UTRITIONAL I MPACT OF P RE- AND P ROBIOTICS AS P ROTECTIVE G ASTROINTESTINAL O RGANISMS
Teitelbaum, J. E., & Walker, W. A. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.110901.145412 · Cited by 298 · see citing works
Forestier, C., de Champs, C., Vatoux, C., & Joly, B. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01188-3 · Cited by 295 · see citing works
Modulating immune responses with probiotic bacteria
Matsuzaki, T., & Chin, J. (2000) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2000.00887.x · Cited by 292 · see citing works
Cavaglieri, C. R., Nishiyama, A., Fernandes, L. C., Curi, R., Miles, E. A., & Calder, P. C. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00490-9 · Cited by 279 · see citing works
Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc
Hahn, J. D., & BAKER, D. H. (1993) · Journal of Animal Science · doi:10.2527/1993.71113020x · Cited by 254 · see citing works
Coconnier, M. H., Klaenhammer, T. R., Kernéis, S. M., Bernet‐Camard, M., & Servin, A. L. (1992) · Applied and Environmental Microbiology · doi:10.1128/aem.58.6.2034-2039.1992 · Cited by 253 · see citing works
Chiang, B., Sheih, Y.-H., Wang, L. H., Liao, C., & Gill, H. S. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601093 · Cited by 238 · see citing works
Physiology of the Gastrointestinal Tract (3rd ed)
Foracs, I. (1995) · Gut · doi:10.1136/gut.37.1.159-a · Cited by 231 · see citing works
The effect of probiotic LSP 122 on the control of post-weaning diarrhoea syndrome of piglets
Kyriakis, S. C., Tsiloyiannis, V. K., Vlemmas, J., Sarris, K., Tsinas, A., Alexopoulos, C., & Jansegers, L. (1999) · Research in Veterinary Science · doi:10.1053/rvsc.1999.0308 · Cited by 231 · see citing works
Konstantinov, S. R., Awati, A., Smidt, H., Williams, B. A., Akkermans, A. D. L., & de Vos, W. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.7.3821-3830.2004 · Cited by 223 · see citing works
Owusu-Asiedu, A., Nyachoti, C. M., & Marquardt, R. R. (2003) · Journal of Animal Science · doi:10.2527/2003.8171790x · Cited by 205 · see citing works
Shu, Q., Qu, F., & Gill, H. S. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200108000-00014 · Cited by 188 · see citing works
Modulation of tight junction structure and function by cytokines
Walsh, S. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00048-x · Cited by 188 · see citing works
Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model
Mariadason, J. M., Barkla, D. H., & Gibson, P. R. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.4.g705 · Cited by 182 · see citing works
Zinc Deficiency, Malnutrition and the Gastrointestinal Tract
Wapnir, R. A. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1388s · Cited by 181 · see citing works
Acid Resistance in Escherichia coli
Richard, H. T., & Foster, J. W. (2003) · Advances in Applied Microbiology · doi:10.1016/s0065-2164(03)01007-4 · Cited by 178 · see citing works
Bouhet, S. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfh006 · Cited by 174 · see citing works
The effect of organic acids on the control of porcine post-weaning diarrhoea
Tsiloyiannis, V. K., Kyriakis, S. C., Vlemmas, J., & Sarris, K. (2001) · Research in Veterinary Science · doi:10.1053/rvsc.2001.0476 · Cited by 168 · see citing works
Katouli, M., Melin, L., Jensen‐Waern, M., Wallgren, P., & Möllby, R. (1999) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1999.00853.x · Cited by 166 · see citing works
Immerseel, F. V. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00542-1 · Cited by 156 · see citing works
Knarreborg, A., Miquel, N., Granli, T., & Jensen, B. B. (2002) · Animal Feed Science and Technology · doi:10.1016/s0377-8401(02)00069-x · Cited by 156 · see citing works
Chauvière, G. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90700-x · Cited by 151 · see citing works
Scott, M. E., & Koski, K. G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1412s · Cited by 138 · see citing works
Canibe, N., Steien, S. H., Øverland, M., & Jensen, B. B. (2001) · Journal of Animal Science · doi:10.2527/2001.7982123x · Cited by 127 · see citing works
Effects of Microbial Feed Additives on Performance of Starter and Growing-finishing Pigs
Pollmann, D. S., Danielson, D. M., & Peo, E. R. (1980) · Journal of Animal Science · doi:10.2527/jas1980.513577x · Cited by 126 · see citing works
Porcine antimicrobial peptides: New prospects for ancient molecules of host defense
Zhang, G., Ross, C. R., & Blecha, F. (2000) · Veterinary Research · doi:10.1051/vetres:2000121 · Cited by 124 · see citing works
Jensen‐Waern, M., Melin, L., Lindberg, R., Johannisson, A., Petersson, L., & Wallgren, P. (1998) · Research in Veterinary Science · doi:10.1016/s0034-5288(98)90130-8 · Cited by 121 · see citing works
Adhesion of Lactic Acid Bacteria to Caco‐2 Cells and Their Effect on Cytokine Secretion
Morita, H., He, F., Fuse, T., Ouwehand, A. C., Hashimoto, H., Hosoda, M., Mizumachi, K., & Kurisaki, J. (2002) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2002.tb02698.x · Cited by 121 · see citing works
Durant, J. A., Corrier, D. E., & Ricke, S. C. (2000) · Journal of Food Protection · doi:10.4315/0362-028x-63.5.573 · Cited by 118 · see citing works
Pabst, R., Geist, M., Rothkötter, H. ‐., & Fritz, F. J. (1988) · PubMed Central · Cited by 116 · see citing works
Li, B. T., Kessel, A. G. V., Caine, W. R., Huang, S. X., & Kirkwood, R. N. (2001) · Canadian Journal of Animal Science · doi:10.4141/a01-043 · Cited by 115 · see citing works
Devriese, L. A., Hommez, J., Pot, B., & Haesebrouck, F. (1994) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1994.tb03040.x · Cited by 112 · see citing works
Jin, L. Z., & Zhao, X. (2000) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000404 · Cited by 112 · see citing works
Stokes, C., Bailey, M., Haverson, K., Harris, C., Jones, P., Inman, C. F., Pié, S., Oswald, I. P., Williams, B. A., Akkermans, A. D. L., et al. (2004) · Animal Research · doi:10.1051/animres:2004020 · Cited by 111 · see citing works
Lactobacillus acidophilus Protects Tight Junctions from Aspirin Damage in HT-29 Cells
Montalto, M., Maggiano, N., Ricci, R., Curigliano, V., Santoro, L., Nicuolo, F. D., Vecchio, F. M., Gasbarrini, A., & Gasbarrini, A. (2004) · Digestion · doi:10.1159/000079152 · Cited by 107 · see citing works
Intestinal Cell Culture Models: Applications in Toxicology and Pharmacology
Sambruy, Y., Ferruzza, S., Ranaldi, G., & Angelis, I. D. (2001) · Cell Biology and Toxicology · doi:10.1023/a:1012533316609 · Cited by 100 · see citing works
Zinc Deficiency Alters Barrier Function of Cultured Porcine Endothelial Cells
Hennig, B., Wang, Y., Ramasamy, S., & McClain, C. J. (1992) · Journal of Nutrition · doi:10.1093/jn/122.6.1242 · Cited by 99 · see citing works
Lehto, E., & Salminen, S. (1997) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1997.tb01037.x · Cited by 97 · see citing works
Adami, A., & Cavazzoni, V. (1999) · Journal of Basic Microbiology · doi:10.1002/(sici)1521-4028(199903)39:1 · Cited by 82 · see citing works
Lipoprotein and apolipoprotein secretion by a newborn piglet intestinal cell line (IPEC-1)
Gonzalez‐Vallina, R., Wang, H., Zhan, R., Berschneider, H. M., Lee, R. M., Davidson, N. O., & Black, D. D. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.2.g249 · Cited by 79 · see citing works
van Heugten, E., Spears, J. W., Kegley, E. B., Ward, J. D., & Qureshi, M. A. (2003) · Journal of Animal Science · doi:10.2527/2003.8182063x · Cited by 73 · see citing works
How to Get Along--Friendly Microbes in a Hostile World
Xavier, R. J., & Podolsky, D. K. (2000) · Science · doi:10.1126/science.289.5484.1483 · Cited by 65 · see citing works
Lessard, M., & Brisson, G. J. (1987) · Canadian Journal of Animal Science · doi:10.4141/cjas87-049 · Cited by 63 · see citing works
Cross-talk between enteric pathogens and the intestine
Uzzau, S., & Fasano, A. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00041.x · Cited by 60 · see citing works
Allen, A. (1989) · Comprehensive physiology · doi:10.1002/cphy.cp060319 · Cited by 51 · see citing works
Hennig, B., Wang, Y., Ramasamy, S., & McClain, C. J. (1993) · Journal of Nutrition · doi:10.1093/jn/123.6.1003 · Cited by 50 · see citing works
Tsukahara, T., & Ushida, K. (2002) · The Journal of General and Applied Microbiology · doi:10.2323/jgam.48.143 · Cited by 49 · see citing works
Canali, R., Vignolini, F., Nobili, F., & Mengheri, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00285-9 · Cited by 44 · see citing works
Effect of dietary zinc supplementation on Escherichia coli septicemia in weaned pigs
Huang, S. X., McFall, M. E., Cegielski, A. C., & Kirkwood, R. N. (1999) · Journal of Swine Health and Production · Cited by 44 · see citing works
Bomba, A., Nemcová, R., Gancarčíková, S., Herich, R., & Kastel, R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4143-1_18 · Cited by 36 · see citing works
Zinc Deficiency Suppresses the Development of Oral Tolerance in Rats
Finamore, A., Roselli, M., Nobili, F., Vignolini, F., Mengheri, E., & Merendino, N. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.191 · Cited by 30 · see citing works
Ontogeny of Pig Discrete Peyer’s Patches: Distribution and Morphometric Analysis
Makala, L. H., KAMADA, T., Nishikawa, Y., Nagasawa, H., Igarashi, I., Fujisaki, K., Suzuki, N., Mikami, T., Haverson, K., Bailey, M., et al. (2000) · Pathobiology · doi:10.1159/000055938 · Cited by 30 · see citing works
Intestinal Cell Culture Models
Sambruy, Y., Ferruzza, S., Ranaldi, G., & Angelis, I. D. (2001) · Springer eBooks · doi:10.1007/978-94-017-0996-5_7 · Cited by 25 · see citing works
Nobili, F., Vignolini, F., Figus, E., & Mengheri, E. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1807 · Cited by 25 · see citing works
Underdahl, N. R. (1983) · PubMed · Cited by 25 · see citing works
Risley, C. R., Kornegay, E. T., Lindemann, M. D., Wood, C. M., & Eigel, W. N. (1993) · Canadian Journal of Animal Science · doi:10.4141/cjas93-094 · Cited by 23 · see citing works
Characterization of Dopuin, a Polypeptide with Special Residue Distributions
Chen, Z., Bergman, T., Östenson, C., Efendić, S., Mutt, V., & Jörnvall, H. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-2-00518.x · Cited by 22 · see citing works
Tc, U., & Nagy, B. (1985) · PubMed · Cited by 22 · see citing works
Zinc, infection and immune function.
Prasad, A. S. (2002) · CABI Publishing eBooks · doi:10.1079/9780851995830.0193 · Cited by 17 · see citing works
Effects of zinc oxide on postweaning diarrhea control in pigs experimentally infected with E. coli.
Morés, N., Cristani, J., Piffer, I. A., Barioni, W., & Lima, G. M. M. (1998) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · Cited by 16 · see citing works
Dietary Zinc Effects on Growth Performance and Immune Response of Endotoxemic Growing Pigs
Roberts, E. S., van Heugten, E., Lloyd, K. L. P., Almond, G. W., & Spears, J. W. (2002) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2002.1496 · Cited by 15 · see citing works
Bosi, P., Merialdi, G., Sarli, G., Casini, L., Gremokolini, C., Preziosi, R., Brunetti, B., & Trevisi, P. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.4081/ijas.2003.s1.361 · Cited by 11 · see citing works
Roggen und Weizen in Ferkelrationen bei Zugabe von Bisergon
Bolduan, G., Jung, H., Schneider, R., & Klenke, B. (1988) · Archiv für Tierernaehrung · doi:10.1080/17450398809428285 · Cited by 9 · see citing works
Postnatal development of the intestinal microbiota of the pig
Akkermans, A. D. L., Konstantinov, S. R., Zhu, W., Favier, C., & Williams, B. A. (2003) · Socio-Environmental Systems Modeling · Cited by 5 · see citing works
Mazzoni, M., Costerbosa, G. L., Casini, L., Petrosino, G., Trevisi, P., Filippi, S. D., & Bosi, P. (2004) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · Cited by 2 · see citing works
Kalina (2002) · doi:10.1002/1521-4141(200209)32:9
Flagged first, then by citations
2 of the 88 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Hampson D.J., Postweaning Escherichia coli diarrhoea in pigs, in: Gyles C.L. (Ed.), Escherichia coli in domestic animals and humans, CAB International, Wallingford, UK, 1994, pp. 171-191.
- Roselli M., Finamore A., Britti M.S., Mengheri E., Protective effects and immunomodulation on intestinal cells by probiotics, Proceeding of the 2nd Probiotics and Prebiotics new foods, 2003, pp. 205-212.
Cited by
Sorted by citations
Heo, J. M., Opapeju, F. O., Pluske, J. R., Kim, J.-C., Hampson, D. J., & Nyachoti, C. M. (2012) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2012.01284.x · Cited by 773 · see citing works
Nutritional management of gut health in pigs around weaning
Lallès, J. P., Bosi, P., Smidt, H., & Stokes, C. R. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005484 · Cited by 568 · see citing works
Weaning — A challenge to gut physiologists
Lallès, J. P., Bosi, P., Smidt, H., & Stokes, C. R. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.01.091 · Cited by 328 · see citing works
The use of probiotics as eco-friendly alternatives for antibiotics in poultry nutrition
Alagawany, M. M., El-Hack, M. E. A., Farag, M. R., Sachan, S., Karthik, K., & Dhama, K. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-1687-x · Cited by 255 · see citing works
Chen, X., Xu, J., Shuai, J., Chen, J., Zhang, Z., & Fang, W. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.11.007 · Cited by 196 · see citing works
Alternatives to antibiotic growth promoters in prevention of diarrhoea in weaned piglets: a review
Vondrušková, H., Slamova, R., Trčková, M., Zralý, Z., & Pavlík, I. (2010) · Veterinární Medicína · doi:10.17221/2998-vetmed · Cited by 196 · see citing works
Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets
Bonetti, A., Tugnoli, B., Piva, A., & Grilli, E. (2021) · Animals · doi:10.3390/ani11030642 · Cited by 187 · see citing works
Sun, Y., & Kim, S. W. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.10.001 · Cited by 155 · see citing works
Persistence of foodborne pathogens and their control in primary and secondary food production chains
Larsen, M., Dalmasso, M., Ingmer, H., Langsrud, S., Malakauskas, M., Mader, A., Møretrø, T., Možina, S. S., Rychli, K., Wagner, M., et al. (2014) · Food Control · doi:10.1016/j.foodcont.2014.03.039 · Cited by 147 · see citing works
Bacterially enriched diet improves sexual performance of sterile male Mediterranean fruit flies
Gavriel, S., Jurkevitch, É., Gazit, Y., & Yuval, B. (2011) · Journal of Applied Entomology · doi:10.1111/j.1439-0418.2010.01605.x · Cited by 140 · see citing works
Denev, S., Staykov, Y., Moutafchieva, R., & Beev, G. (2009) · International aquatic research. · Cited by 133 · see citing works
Sales, J. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9638-3 · Cited by 117 · see citing works
Lallès, J. P., Bosi, P., Janczyk, P., Koopmans, S. J., & Torrallardona, D. (2009) · animal · doi:10.1017/s175173110900398x · Cited by 111 · see citing works
(FEEDAP), E. P. O. A. A. P. O. S. U. I. A. F. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3668 · Cited by 98 · see citing works
Strompfová, V., Marciňáková, M., Simonová, M. P., Gancarčíková, S., Jonecová, Z., Sciranková, L., Koščová, J., Buleca, V., Čobanová, K., & Lauková, A. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.09.003 · Cited by 91 · see citing works
Organic Acids Mixture as a Dietary Additive for Pigs—A Review
Nguyen, D. H., Seok, W. J., & Kim, I. H. (2020) · Animals · doi:10.3390/ani10060952 · Cited by 89 · see citing works
A history of antimicrobial drugs in animals: Evolution and revolution.
Lees, P., Pelligand, L., Giraud, E., & Toutain, P. (2020) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/jvp.12895 · Cited by 70 · see citing works
Role of probiotics in nutrition and health of small ruminants
EL-TAWAB, M. M. A., Youssef, I. M. I., Bakr, H. A., Fthenakis, G. C., & Giadinis, N. D. (2016) · Polish Journal of Veterinary Sciences · doi:10.1515/pjvs-2016-0114 · Cited by 85 · see citing works
Alternatives to antibiotics for farm animals.
Papatsiros, V. G., Katsoulos, P. D., Koutoulis, K. C., Karatzia, M. A., Dedousi, A., & Christodoulopoulos, G. (2014) · CABI Reviews · doi:10.1079/pavsnnr20138032 · Cited by 91 · see citing works
Halas, D., Hansen, C. F., Hampson, D. J., Mullan, B. P., Kim, J.-C., Wilson, R. H., & Pluske, J. R. (2010) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2010.07.001 · Cited by 83 · see citing works
The mucosal immune system: Recent developments and future directions in the pig
Bailey, M. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.07.003 · Cited by 78 · see citing works
Performance, digestive function, and mucosal responses to selected feed additives for pigs
Kiarie, E. G., Walsh, M. C., & Nyachoti, C. M. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-9835 · Cited by 68 · see citing works
Li, P., Niu, Q., Wei, Q., Zhang, Y., Ma, X., Kim, S. W., Lin, M., & Huang, R. (2017) · Scientific Reports · doi:10.1038/srep41395 · Cited by 59 · see citing works
Canibe, N., Miettinen, H. O., & Jensen, B. B. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.05.002 · Cited by 56 · see citing works
Dietary zinc oxide nanoparticles as growth promoter for weanling pigs
Milani, N. C., Sbardella, M., Ikeda, N. Y., Arno, A., Mascarenhas, B. C., & Miyada, V. S. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.03.001 · Cited by 56 · see citing works
Kantas, D., Papatsiros, V. G., Tassis, P. D., Giavasis, I., Bouki, P., & Tzika, E. D. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12729 · Cited by 52 · see citing works
Wang, Q., Ying, J., Zou, P., Zhou, Y., Wang, B., Yu, D., Li, W., & Zhan, X. (2020) · Animals · doi:10.3390/ani10112104 · Cited by 51 · see citing works
Xu, C., Wang, Y., Sun, R., Qiao, X., Shang, X., & Niu, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104183 · Cited by 49 · see citing works
Satessa, G. D., Kjeldsen, N. J., Mansouryar, M., Hansen, H. H., Bache, J. K., & Nielsen, M. O. (2020) · animal · doi:10.1017/s1751731120000154 · Cited by 48 · see citing works
Du, Y., Li, H., Shao, J., Wu, T., Xu, W., Hu, X., & Chen, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.878874 · Cited by 45 · see citing works
Shi, J., Yu, L., Wu, J., Li, Z., Zhang, X., Li, J., Wang, Y., Ma, Y., Zhang, K., Cheng, Q., et al. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00832-5 · Cited by 43 · see citing works
Isolation and Selection of Potential Probiotic Bacteria from the Pig Gastrointestinal Tract
Verso, L. L., Lessard, M., Talbot, G., Fernandez, B., & Fliss, I. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9309-3 · Cited by 43 · see citing works
Role of vitamins for gastro-intestinal functionality and health of pigs
Lauridsen, C., Matte, J. J., Lessard, M., Celi, P., & Litta, G. (2021) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2021.114823 · Cited by 42 · see citing works
Kaevska, M., Lorencová, A., Videnska, P., Sedlář, K., Provazník, I., & Trčková, M. (2016) · Veterinární Medicína · doi:10.17221/54/2016-vetmed · Cited by 41 · see citing works
Mohammadigheisar, M., Shirley, R. B., Barton, J., Welsher, A., Thiery, P., & Kiarie, E. G. (2019) · Poultry Science · doi:10.3382/ps/pez305 · Cited by 39 · see citing works
(EFSA), E. F. S. A. (2007) · EFSA Journal · doi:10.2903/j.efsa.2007.572 · Cited by 35 · see citing works
Stensland, I., Kim, J.-C., Bowring, B. G., Collins, A. M., Mansfield, J. P., & Pluske, J. R. (2015) · Animals · doi:10.3390/ani5040403 · Cited by 33 · see citing works
Cell surface proteins play an important role in probiotic activities of Lactobacillus reuteri
Singh, T. P., Malik, R. K., & Kaur, G. (2016) · Nutrire · doi:10.1186/s41110-016-0007-9 · Cited by 32 · see citing works
Lan, R., & Kim, I. H. (2019) · Veterinary Medicine and Science · doi:10.1002/vms3.215 · Cited by 32 · see citing works
Effects of medium-chain fatty acids on the structure and immune response of IPEC-J2 cells
Martínez-Vallespín, B., Vahjen, W., & Zentek, J. (2016) · Cytotechnology · doi:10.1007/s10616-016-0003-1 · Cited by 30 · see citing works
O'Doherty, J., Bouwhuis, M., & Sweeney, T. (2017) · Animal Production Science · doi:10.1071/an17272 · Cited by 27 · see citing works
Escherichia�coli O101‑induced diarrhea develops gut microbial dysbiosis in rats
Sun, X., Gao, Y., Wang, X., Hu, G., Wang, Y., Feng, B., Hu, Y., Mu, X., Zhang, Y., & Dong, H. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6997 · Cited by 27 · see citing works
Zhu, K. H., Xu, X., Sun, D., Tang, J. L., & Zhang, Y. (2014) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2014.01.014 · Cited by 25 · see citing works
(EFSA), E. F. S. A. (2007) · EFSA Journal · doi:10.2903/j.efsa.2007.564 · Cited by 25 · see citing works
Qin, S., Xiao, X., Dai, Z., Zhao, G., Cui, Z., Wu, Y., & Yang, C. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103210 · Cited by 24 · see citing works
Grecco, H. A. T., Amorim, A. B., Saleh, M. A. D., Tse, M. L. P., Telles, F. G., MIASSI, G. M., Pimenta, G. E. M., & Berto, D. A. (2018) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201820160057 · Cited by 24 · see citing works
Yuan, D., Wang, J., Xiao, D., Li, J., Liu, Y., Tan, B., & Yin, Y. (2020) · Animals · doi:10.3390/ani10111998 · Cited by 22 · see citing works
Feeding Marine Polysaccharides to Alleviate the Negative Effects Associated with Weaning in Pigs
O’Doherty, J. V., Venardou, B., Rattigan, R., & Sweeney, T. (2021) · Animals · doi:10.3390/ani11092644 · Cited by 20 · see citing works
Probiotics as alternatives to antibiotics in treating post-weaning diarrhoea in pigs: Review paper
Bogere, P., Choi, Y. J., & Heo, J.-Y. (2019) · South African Journal of Animal Science · doi:10.4314/sajas.v49i3.1 · Cited by 20 · see citing works
Rodrigues, M. A. M., Silva, D. A. D. O., Taketomi, E. A., & Hernandez‐Blazquez, F. J. (2007) · Pesquisa Veterinária Brasileira · doi:10.1590/s0100-736x2007000600004 · Cited by 20 · see citing works
Patience, J. F., & Ramirez, A. (2022) · Translational Animal Science · doi:10.1093/tas/txac063 · Cited by 20 · see citing works
Peeters, L., Mostin, L., Wattiau, P., Boyen, F., Dewulf, J., & Maes, D. G. D. (2018) · Livestock Science · doi:10.1016/j.livsci.2018.12.019 · Cited by 19 · see citing works
Regulation of immune response at intestinal and peripheral sites by probiotics
Britti, M. S., Roselli, M., Finamore, A., Merendino, N., & Mengheri, E. (2006) · Biologia · doi:10.2478/s11756-006-0150-5 · Cited by 18 · see citing works
Nagpal, R., Shrivastava, B., Kumar, N., Dhewa, T., & Sahay, H. (2015) · Springer eBooks · doi:10.1007/978-81-322-2401-3_12 · Cited by 17 · see citing works
Muneeb, M., Khan, E. U., Ahmad, S., Naveed, S., Ali, M., Qazi, M. A., Ahmad, T., & Abdollahi, M. R. (2024) · World s Poultry Science Journal · doi:10.1080/00439339.2024.2330934 · Cited by 14 · see citing works
Probiotics and Prebiotics for Promoting Health
Kumar, M., Nagpal, R., Rajkumar, H., Yadav, H., & Marotta, F. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802189-7.00006-x · Cited by 14 · see citing works
Mazzoni, M., Merialdi, G., Sarli, G., Trevisi, P., & Bosi, P. (2010) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2010.90352 · Cited by 12 · see citing works
Unraveling piglet gut microbiota dynamics in response to feed additives
Gutiérrez, O. P. (2010) · doi:10.18174/139643 · Cited by 12 · see citing works
Ribeiro, A. G., Rabello, C. B.-V., dos Santos, M. J. B., Nascimento, J. C. D. S., da Silva, D. A., Oliveira, H. S. D. H., Macambira, G. M., dos Santos, A. C. F., Maciel, M. D. S., Carvalho, C. B. D. M., et al. (2021) · Research Society and Development · doi:10.33448/rsd-v10i10.18800 · Cited by 11 · see citing works
van der Meulen, J., Hulst, M., Smits, M. A., & Schuurman, T. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0025 · Cited by 8 · see citing works
Zhao, P., Zhang, Z., Lan, R., Li, T., & Kim, I. H. (2017) · Journal of Applied Animal Research · doi:10.1080/09712119.2017.1420655 · Cited by 8 · see citing works
Bass, N. G., Ron, T., Vago, R., Shirizly, A., & Aghion, E. (2021) · Materials · doi:10.3390/ma14164682 · Cited by 8 · see citing works
Zhang, Z. F., Cho, J. H., & Kim, I. H. (2013) · Journal of Animal Science and Technology · doi:10.5187/jast.2013.55.4.295 · Cited by 8 · see citing works
Uso de aditivos equilibradores de microbiota na alimentação de aves comerciais: Revisão
da Silva, D. A., Rabello, C. B.-V., dos Santos, M. J. B., Nascimento, J. C. D. S., Ribeiro, A. G., Macambira, G. M., Oliveira, H. S. D. H., dos Santos, A. C. F., da Silva, L. A. L., Mota, M. A. A., et al. (2021) · Research Society and Development · doi:10.33448/rsd-v10i7.16633 · Cited by 7 · see citing works
Bissonnette, N., Jiang, X., Matte, J. J., Guay, F., Talbot, G., Bontempo, V., Gong, J., Wang, Q., & Lessard, M. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.10.004 · Cited by 7 · see citing works
van Krimpen, M. M., Hulst, M., van der Meulen, J., Schokker, D., Savelkoul, H. F. J., Tijhaar, E. J., & Rutten, V. P. M. G. (2014) · Cited by 7 · see citing works
Cytokine response after stimulation of culture cells by zinc and probiotic strain
Šefcová, M. A., Levkut, M., Bobíková, K., Karaffová, V., Révajová, V., Maruščáková, I. C., Levkutova, M., Ševčíková, Z., Herich, R., & Levkut, M. (2019) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-019-00401-z · Cited by 7 · see citing works
Kinara, E., Moturi, J., Hosseindoust, A., Mun, J. Y., Tajudeen, H., Ha, S. H., Park, S. R., Lee, S. H., & Kim, J. (2024) · Journal of Animal Science and Technology · doi:10.5187/jast.2024.e58 · Cited by 6 · see citing works
Probiotics, prebiotics, and synbiotics in animal and poultry nutrition
Alagawany, M. M., Hegazy, M. I., Farag, M. R., El-Shall, N. A., Sallam, S. M. A., & Dhama, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13510-1.00002-5 · Cited by 6 · see citing works
Barbosa, A. M. S., Carvalho, M. P. S., Naves, L. D. P., da Motta, S. A. B., Chaves, R. F., Resende, M., de Lima, D., Hansen, L. H. B., & Cantarelli, V. D. S. (2024) · Animals · doi:10.3390/ani14233511 · Cited by 6 · see citing works
Rao, S. (2007) · ThinkTech (Texas Tech University) · Cited by 6 · see citing works
Hu, B., Liu, T., Xia, B., Dong, Y., Liu, M., & Zhou, J. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.05.010 · Cited by 4 · see citing works
Effect of essential oils on gut bacteria and functionality in the pig
Michiels, J. (2009) · Ghent University Academic Bibliography (Ghent University) · Cited by 4 · see citing works
Geervliet, M. (2021) · doi:10.18174/553257 · Cited by 2 · see citing works
Screening of Organic Acid Type and Dosage in Drinking Water for Young Rabbits
Ramón-Moragues, A., Vaggi, C. M., Franch-Dasí, J., Martínez-Paredes, E. M., Peixoto-Gonçalves, C., Ródenas, L., López-Luján, M. D. C., Marín‐García, P. J., Blas, E., Pascual, J. J., et al. (2024) · Animals · doi:10.3390/ani14152177 · Cited by 2 · see citing works
Shin, M.-S., Choi, H.-J., Jeong, K.-H., Lim, J.-C., Kim, K.-S., & Lee, W.-K. (2012) · Korean Journal for Food Science of Animal Resources · doi:10.5851/kosfa.2012.32.1.31 · Cited by 2 · see citing works
Uso estratégico de aditivos: impacto sobre el equilibrio y salud gastrointestinal del lechón
Soraci, A. L., Amanto, F. A., Harkes, R., Pérez, D. S., Martínez, G., Diéguez, S. N., & Tapia, M. O. (2010) · Analecta Veterinaria · Cited by 2 · see citing works
Bolado-Martínez, E., & Acedo‐Félix, E. (2009) · Czech Journal of Animal Science · doi:10.17221/1722-cjas · Cited by 2 · see citing works
Probiotics in Poultry Nutrition as a Natural Alternative for Antibiotics
El-Hack, M. E. A., Alagawany, M. M., El-Shall, N. A., Shehata, A. M., Abdel-Moneim, A.-M. E., & Naiel, M. A. E. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815049015122010013 · Cited by 1 · see citing works
Nutritional strategies to reduce the impact of Escherichia coli in newly weaned pigs
Wensley, M. R., Tokach, M. D., Woodworth, J. C., Goodband, R. D., DeRouchey, J. M., & Gebhardt, J. T. (2023) · Journal of Swine Health and Production · doi:10.54846/jshap/1318 · Cited by 1 · see citing works
Ma, Y.-H. (2016) · TSpace (University of Toronto) · Cited by 1 · see citing works
Lin, X., Zhang, T., Ju, L., Jiang, Y. Q., Hou, Q., Hu, Z., Wang, Y., & Wang, Z. (2021) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2021.127014 · Cited by 1 · see citing works
An Overview of Alternatives for Conventional Antibiotics
van der Helm, A. J. M. (2014) · Utrecht University Repository (Utrecht University) · Cited by 1 · see citing works
Montagné, L., Lallès, J. P., Huërou‐Luron, I. L., & Floc'H, N. L. (2009) · INRAE Productions Animales · doi:10.20870/productions-animales.2009.22.1.3329 · Cited by 1 · see citing works
The potential of probiotics as in-feed growth enhancers for swine
Wealleans, A. L., & Litten-Brown, J. C. (2010) · Food Science & Technology Bulletin Functional Foods · doi:10.1616/1476-2137.15972
Novakovic, P. (2012) · University Library - University of Saskatchewan (University of Saskatchewan)
STUDY OF THE INTESTINAL STRUCTURE OF BROILERS FED WITH DIFFERENT LEVELS OF SODIUM BUTYRATE
Benevides, W., Dias, M. P., & Vinatea, V. (2012)
In Search of Health-Promoting Microbes: In Vitro and In Vivo Studies in Swine
Lähteinen, T. (2014) · Työväentutkimus Vuosikirja
Hayhoe, M.-A. (2013) · The Atrium (University of Guelph)
Mendéz, M. S. C., da Silva, A. M., Andretta, I., & Hauschild, L. (2022) · Editora Científica Digital eBooks · doi:10.37885/220207574
ÁCIDOS ORGÂNICOS NA NUTRIÇÃO DE PORCAS GESTANTES E SEUS EFEITOS NA PROGÊNIE: META-ANÁLISE
Mendéz, M. S. C., da Silva, A. M., Andretta, I., & Hauschild, L. (2022) · Editora Científica Digital eBooks · doi:10.37885/220207573
(2023) · CABI eBooks · doi:10.1079/9781789247282.0016
Le, T. T. T., Tran, L. V. P., Phan, H. M., & Ngo, T. P. H. (2025) · Journal of Fish Diseases · doi:10.1111/jfd.70101
Grecco, H. A. T. (2014) · Americanae (AECID Library)
Ramón-Moragues, A., Franch-Dasí, J., López-Luján, M. C., Martínez-Paredes, E. M., Ródenas, L., Moya, V. J., Peixoto-Gonçalves, C., Marín-García, P. J., Pascual, J. J., & Cambra-López, M. (2026) · animal · doi:10.1016/j.animal.2026.101936
- Authors
- Roselli, M., Finamore, A., Britti, M. S., Bosi, P., Oswald, I., & Mengheri, E.
- Affiliations
- Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (IT)
- University of Bologna (IT)
- Institut National de la Recherche Agronomique (FR)
- Venue
- Animal Research
- Publisher
- EDP Sciences
- Published
- 2005-05
- Volume
- 54
- Issue
- 3
- Pages
- 203-218
- ISSN
- 1627-3583 (ISSN-L)
- 1627-3591
- OpenAlex
- W2151921633
- Cited by
- 97
- References
- 88
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 10 · 2013: 3 · 2012: 4
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Animal Research (publishedVersion)
- Springer Link (Chiba Institute of Technology) (submittedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- weaned piglets, probiotics, zinc oxide, organic acids, intestinal mucosa protection, intestinal epithelial cells, epithelial cytoskeleton, tight junctions, host immune response, antibiotic resistance, in vitro cell culture model, inflammatory processes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
