Probiotic immunomodulation in health and disease

Erickson, Kent L.; Hubbard, Neil E.

doi:10.1093/jn/130.2.403s

Cited by 372Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Probiotic immunomodulation in health and disease

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Erickson, Kent L., Hubbard, Neil E.·2000·The Journal of Nutrition

DOI 10.1093/jn/130.2.403s

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Abstract

Probiotics, microorganisms that have a favorable influence on physiologic and pathological processes of the host by their effect on the intestinal flora, may play a role in improving human health. One of the putative effects is the modulation of immune function. Thus, the mucosal immune system and methods to assess its function are reviewed briefly. Probiotic modulation of humoral, cellular and nonspecific immunity is reviewed, with emphasis placed on immune response in disease models. There are very few reports of human intervention studies with probiotics. However, some of the possible future directions for research with respect to probiotics, immunity, and human health are discussed. Although the application of probiotics has demonstrated trends with respect to altered aspects of immune response, the underlying mechanisms by which that occurs are unclear.

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Some LAB strains can modulate innate and acquired immune responses by binding to specific receptors on immune cells and other tissues, and by stimulating production of cytokines, T cells, activation of dendritic cells and macrophages, and production of specific antibodies.
“Some LAB strains can modulate innate and acquired immune responses by binding to specific receptors on immune cells and other tissues such as intestinal epithelial tissue, and by stimulating the production of cytokines, T cells, the activation of dendritic cells and macrophages, and the production of specific antibodies [229,230,231].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [229]

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Authors: Erickson, K. L., & Hubbard, N. E.
Affiliations: University of California, Davis (US)
Corresponding author: Erickson, Kent L.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2000-02
Volume: 130
Issue: 2
Pages: 403S-409S
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/130.2.403s
OpenAlex: W1946934775
Cited by: 372
References: 25
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 14 · 2021: 10 · 2020: 19 · 2019: 8 · 2018: 15 · 2017: 7 · 2016: 6 · 2015: 21 · 2014: 16 · 2013: 15 · 2012: 21
FWCI: 26.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 8396 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, immunomodulation, mucosal immunity, gut microbiota, humoral immunity, cell-mediated immunity, non-specific immunity, disease models, human health
MeSH terms: Animals, Disease Models, Animal, Humans, Immune System, Intestines, Immunity, Mucosal, Probiotics

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