The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
n-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?
Open accessAbstract
n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), mainly eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), are present in mammal tissues both from endogenous synthesis from desaturation and elongation of 18:3 n-3 and/or from dietary origin (marine products and fish oils). In rodents in vivo, n-3 LC-PUFA have a protective effect against high fat diet induced insulin resistance. Such an effect is explained at the molecular level by the prevention of many alterations of insulin signaling induced by a high fat diet. Indeed, the protective effect of n-3 LC-PUFA results from the following: (a) the prevention of the decrease of phosphatidyl inositol 3' kinase (PI3 kinase) activity and of the depletion of the glucose transporter protein GLUT4 in the muscle; (b) the prevention of the decreased expression of GLUT4 in adipose tissue. In addition, n-3 LC-PUFA inhibit both the activity and expression of liver glucose-6-phosphatase which could explain the protective effect with respect to the excessive hepatic glucose output induced by a high fat diet. n-3 LC-PUFA also decrease muscle intramyofibrillar triglycerides and liver steatosis. This last effect results on the one hand, from a decreased expression of lipogenesis enzymes and of delta 9 desaturase (via a depleting effect on sterol response element binding protein 1c (SREBP-1c). On the other hand, n-3 LC-PUFA stimulate fatty acid oxidation in the liver (via the activation of peroxisome proliferator activated receptor alpha (PPAR-alpha)). In patients with type 2 diabetes, fish oil dietary supplementation fails to reverse insulin resistance for unclear reasons, but systematically decreases plasma triglycerides. Conversely, in healthy humans, fish oil has many physiological effects. Indeed, fish oil reduces insulin response to oral glucose without altering the glycaemic response, abolishes extraggression at times of mental stress, decreases the activation of sympathetic activity during mental stress and also decreases plasma triglycerides. These effects are encouraging in the perspective of prevention of insulin resistance but further clinical and basic studies must be designed to confirm and complete our knowledge in this field.
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Cites
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Nonalcoholic Fatty Liver Disease
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Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats
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“Studies from Storlien’s group have demonstrated that the substitution of fish oil (rich in n-3 long chain n-3 fatty acids) for saturated (tallow) or monoinsaturated (olive oil) or polyunsaturated n-6 (safflower oil) high fat diets (60% fat) in rats over 3 weeks completely prevented liver and muscle insulin resistance…”
BackgroundDIABETES INCIDENCE IN PIMA INDIANS: CONTRIBUTIONS OF OBESITY AND PARENTAL DIABETES1
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Intramuscular lipid content is increased in obesity and decreased by weight loss
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“This excess of skeletal muscle triglycerides has been observed in obese and in type 2 diabetics [11, 12].”
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Ryysy, L., Häkkinen, A. M., Goto, T., Vehkavaara, S., Westerbacka, J., Halavaara, J., & Yki-Järvinen, H. (2000) · Diabetes · doi:10.2337/diabetes.49.5.749 · Cited by 431
Cited by
Defining high-fat-diet rat models: Metabolic and molecular effects of different fat types
Buettner, R., Parhofer, K. G., Woenckhaus, M., Wrede, C. E., Kunz-Schughart, L. A., Schölmerich, J., & Bollheimer, L. C. (2006) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01909 · Cited by 704
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Lipid accumulation in non-adipose tissue and lipotoxicity
van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500
Omega-3 fatty acids in obesity and metabolic syndrome: A mechanistic update
Albracht-Schulte, K., Kalupahana, N. S., Ramalingam, L., Wang, S., Rahman, S. M., Robert-McComb, J., & Moustaid-Moussa, N. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.012 · Cited by 355
“Another such potential mechanism relates to the ability of n-3 PUFA to lower cortisol levels [189].”
BackgroundSkeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise
Corcoran, M. P., Lamon-Fava, S., & Fielding, R. A. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.662 · Cited by 341
Metadata
- Authors
- Delarue, J., LeFoll, C., Corporeau, C., & Lucas, D.
- Venue
- Reproduction Nutrition Development
- Publisher
- EDP Sciences
- Published
- 2004-05
- Volume
- 44
- Issue
- 3
- Pages
- 289-299
- ISSN
- 0003-388X (ISSN-L)
- 0926-5287
- 1297-9708
- OpenAlex
- W2150446149
- Cited by
- 205
- References
- 15
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
