Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise

Corcoran, Michael P; Lamon-Fava, Stefania; Fielding, Roger A

doi:10.1093/ajcn/85.3.662

Cited by 341Muscle metabolism and nutritionAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise

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Corcoran, Michael P, Lamon-Fava, Stefania, Fielding, Roger A·2007·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/85.3.662

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Abstract

Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations are associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation is most likely due to enhanced fatty acid uptake into the muscle coupled with diminished mitochondrial lipid oxidation. The excess fatty acids are esterified and either stored or metabolized to various molecules that may participate or interfere with normal cellular signaling, particularly insulin-mediated signal transduction, thus altering cellular and, subsequently, whole-body glucose metabolism. Impaired insulin responsiveness, if not managed, can further progress to type 2 diabetes mellitus, an all too common condition. For most of the human population this is avoidable, given that causes of intramyocellular lipid deposition are predominantly lifestyle-mediated. Chronic overconsumption of calories coupled with deleterious intakes of saturated or trans-unsaturated fatty acids inconsistent with the recommendations outlined in the Dietary Guidelines for Americans have been shown to increase the risk of insulin resistance. Furthermore, lack of exercise, which can have a profound effect on skeletal muscle lipid turnover, is implicated in this lipid-induced insulin resistance. This review summarizes the current understanding of the effects of elevated intramyocellular lipids on insulin signaling and how these effects may be altered by varying dietary fat composition and exercise.

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Authors: Corcoran, M. P., Lamon-Fava, S., & Fielding, R. A.
Affiliations: Tufts University (US)
ORCID: Corcoran, Michael P
Fielding, Roger A
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2007-03
Volume: 85
Issue: 3
Pages: 662-677
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/85.3.662
OpenAlex: W2171719931
Cited by: 341
References: 228
Citations by year: 2026: 8 · 2025: 13 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 13 · 2020: 17 · 2019: 14 · 2018: 11 · 2017: 26 · 2016: 19 · 2015: 36 · 2014: 26 · 2013: 23 · 2012: 23
FWCI: 1.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5843 d)
Locations: American Journal of Clinical Nutrition (publishedVersion, cc-by)
PubMed (publishedVersion)
UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (T32HL069772)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: insulin resistance, dietary fatty acids, saturated fatty acids, trans fatty acids, physical activity, insulin signaling, fatty acid uptake, type 2 diabetes, glucose metabolism, Dietary Guidelines for Americans
MeSH terms: Dietary Fats, Fatty Acids, Glucose, Humans, Inflammation, Insulin Resistance, Isoenzymes, Lipids, Mitochondria, Protein Kinase C, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal

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Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise

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