Cited by 243Alcohol Consumption and Health EffectsNitric Oxide and Endothelin EffectsDrug-Induced Hepatotoxicity and Protection

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Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice

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McKim, Stephen E, Gäbele, Erwin, Isayama, Fuyumi, Lambert, Jason C, Tucker, Lindsay M, Wheeler, Michael D, Connor, Henry D, Mason, Ronald P, Doll, Mark A, Hein, David W, Arteel, Gavin E·2003·Gastroenterology

DOI 10.1053/j.gastro.2003.08.030

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Abstract

Background & aims Oxidative stress contributes to early alcohol-induced liver injury, and superoxide (O(2)*-) production from NADPH oxidase plays a key role. However, the production of the free radical nitric oxide (NO*) by inducible nitric oxide synthase (iNOS) could also be involved.Methods To test this hypothesis, iNOS knockout (B6.129P2-Nos2 (tm1 Lau)) and wild-type mice were fed high-fat control or ethanol-containing diets for 4 weeks.Results Mean body weight gains were not significantly different between treatment groups, and average urine ethanol concentrations were similar in wild-type and iNOS knockout mice. After 4 weeks, serum alanine aminotransferase (ALT) levels were increased significantly about 4-fold over control values (29 +/- IU/L) by enteral ethanol (113 +/- 20) in wild-type mice; this effect of ethanol was significantly blunted in iNOS knockout mice (50 +/- 9). Similar protective effects against liver damage were observed if wild-type mice were treated with the iNOS inhibitor N -(3-aminomethyl)benzyl-acetamindine (1400W). Enteral ethanol also caused severe fatty accumulation, mild inflammation, and necrosis in the liver in wild-type mice but had no effect in iNOS knockout mice. The accumulation of 4-hydroxynonenal (lipid peroxidation) and 3-nitrotyrosine (reactive nitrogen species formation) protein adducts caused by alcohol was completely blocked in iNOS knockout mice.Conclusions These data strongly support the hypothesis that iNOS is required for the pathogenesis of early alcohol-induced hepatitis by production of nitric oxide-derived pro-oxidants (e.g., peroxynitrite).

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Methods of Enzymatic Analysis
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338
Methods of Enzymatic Analysis
Matthews, R. (1987) · Journal of Clinical Pathology · doi:10.1136/jcp.40.8.934-a · Cited by 1,187
Simulation of Multiple Isotropic Spin-Trap EPR Spectra
Duling, D. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1062 · Cited by 940
Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System
Klebanoff, S. J. (1968) · Journal of Bacteriology · doi:10.1128/jb.95.6.2131-2138.1968 · Cited by 820
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite
van der Vliet, A., Eiserich, J. P., Halliwell, B., & Cross, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7617 · Cited by 780
β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
Combs, C. K., Karlo, J. C., Kao, S.-C., & Landreth, G. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01179.2001 · Cited by 721
Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice
Yin, M., Wheeler, M. D., Kono, H., Bradford, B. U., Gallucci, R. M., Luster, M. I., & Thurman, R. G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70354-9 · Cited by 699
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Research works printed but not linked: 2

Knecht, 1995, Free radical adducts in the bile of rats treated chronically with intragastric alcohol, Mol Pharmacol, 47, 1028
Thurman, 1998, Mechanisms of hepatic toxicity, Am J Physiol, 275, G605

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Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Saito, K., Imawari, M., Yokochi, T., Moriwaki, H., & Seishima, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.075 · Cited by 12
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Zhong, Z., & Lemasters, J. J. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.08.006 · Cited by 12
Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia
Santos-Molina, L., Herrerias, A., Zawatsky, C. N., Gunduz‐Cinar, O., Çınar, R., Iyer, M. R., Wood, C. M., Lin, Y., Gao, B., Kunos, G., et al. (2021) · Molecules · doi:10.3390/molecules26165089 · Cited by 12
Antioxidant Therapy in Chronic Liver Diseases
Lengyel, G., & Tulassay, Z. (2008) · Hungarian Medical Journal · doi:10.1556/hmj.2.2008.27811 · Cited by 12
Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)
Sánchez, V., Baumann, A., Kromm, F., Yergaliyev, T., Brandt, A., Scholda, J., Kopp, F. B., Camarinha‐Silva, A., & Bergheim, I. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00950-4 · Cited by 11
Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide
Farahani, A., Farahani, A., Kashfi, K., & Ghasemi, A. (2025) · Medical Gas Research · doi:10.4103/mgr.medgasres-d-24-00100 · Cited by 13
Influence of aging on ethanol-induced oxidative stress in digestive tract of rats
Vučević, D. B., Mladenović, D. R., Ninković, M., Stanković, M., Jorgačević, B. Z., Stanković, M. N., Luka, S. R. D., & Radosavljević, T. S. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112467045 · Cited by 11
Chronic liver injury in mice promotes impairment of skin barrier functionviatumor necrosis factor-alpha
Yokoyama, S., Hiramoto, K., Koyama, M., & Ooi, K. (2015) · Cutaneous and Ocular Toxicology · doi:10.3109/15569527.2015.1076433 · Cited by 11
Acute Ethanol Gavage Attenuates Hemorrhage/Resuscitation-Induced Hepatic Oxidative Stress in Rats
Relja, B., Wilhelm, K., Wang, M.-H., Henrich, D., Marzi, I., & Lehnert, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/983427 · Cited by 11
Roles of Kupffer Cells in Alcoholic Liver Disease
Takei, Y., Arteel, G. E., Bergheim, I., Lambert, J. C., McMullen, M. R., Nagy, L. E., Enomoto, N., & Sato, N. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000168169.20591.64 · Cited by 11
Self-citation
Effect of the nitric oxide donor and the nitric oxide synthase inhibitor on the liver of rats with chronic hepatitis induced by dimethylnitrosamine.
Lukivskaya, O., Лис, Р. Е., Zwierz, K., & Buko, V. (2004) · PubMed · Cited by 11
Synergistic Interaction of Light Alcohol Administration in the Presence of Mild Iron Overload in a Mouse Model of Liver Injury: Involvement of Triosephosphate Isomerase Nitration and Inactivation
Gao, W., Zhao, J. J., Gao, Z., & Li, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170350 · Cited by 11
Diethylcarbamazine: Possible therapeutic alternative in the treatment of alcoholic liver disease in C57 BL /6 mice
Rodrigues, G. B., Rocha, S. W. S., dos Santos, L. A. M., de Oliveira, W. H., Gomes, F. O. D. S., de França, M. E. R., Lós, D. B., & Peixoto, C. A. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12369 · Cited by 10
BROWN SEAWEEDS AMELIORATE RENAL ALTERATIONS IN MICE TREATED WITH THE CARCINOGEN AZOXYMETHANE
Mahmoud, A. M., El-Derby, A. M., Elsayed, K. N. M., & Abdella, E. M. (2014) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 10
Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress
Lu, Y., Leung, T. M., Ward, S. C., & Nieto, N. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00375.2011 · Cited by 10
Role of EGF/ERK1/2/HO-1 axis in mediating methotrexate induced testicular damage in rats and the ameliorative effect of xanthine oxidase inhibitors
Rofaeil, R. R., Ibrahim, M. A., Mohyeldin, R. H., El‐Tahawy, N. F. G., & Abdelzaher, W. Y. (2023) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2023.2181684 · Cited by 9
Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke’s encephalopathy: Findings in preclinical models and in a postmortem human case
Moya, M., Escudero, B., Gómez-Blázquez, E., Poves, A. B. R., López‐Gallardo, M., Guerrero, C., Marco, E. M., & Orío, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.866574 · Cited by 11
Nitric oxide donors prevent while the nitric oxide synthase inhibitor l-NAME increases arachidonic acid plus CYP2E1-dependent toxicity
Wu, D., & Cederbaum, A. I. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.05.019 · Cited by 9
A renoprotective role of chitosan against lithium-induced renal toxicity in rats
Aboulthana, W. M., & Ibrahim, N. E. (2018) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-018-0029-y · Cited by 9
Leveraging oxidative stress questions in vivo: Implications and limitations
Arteel, G. E. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.009 · Cited by 8
Self-citation
Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice
Ishida, Y., Zhang, S., Kuninaka, Y., Ishigami, A., Nosaka, M., Harie, I., Kimura, A., Mukaida, N., & Kondo, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097845 · Cited by 8
CYP2E1, oxidative stress and MAPK signaling pathways in alcohol-induced hepatotoxicity
Yang, L., Wu, D., & Cederbaum, A. I. (2014) · Cited by 8
Inflammation and Hepatotoxicity
Luyendyk, J. P., Roth, R. A., & Ganey, P. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01031-9 · Cited by 8
Interaction between LPS-induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Vα14 NKT cells
Ohtaki, H., Ito, H., Ando, K., Ishikawa, T., Hoshi, M., Tanaka, R., Osawa, Y., Yokochi, T., Moriwaki, H., Saito, K., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.120 · Cited by 8
Pathogenesis of Alcoholic Liver Disease
Arteel, G. E., & Crabb, D. W. (2015) · Springer eBooks · doi:10.1007/978-3-319-20538-0_3 · Cited by 8
Self-citation
Upregulation of Nrf2/HO-1 signaling and farnesoid X receptor and attenuation of oxidative stress and inflammation mediate the protective effect of sitagliptin against diabetic nephropathy in rats
Hasan, I. H., Alqahtani, Q. H., Sarawi, W. S., ALMatrafi, T. A., Alsaab, J. S., Hassanein, E. H. M., Ahmed, N. A., Mohtadi, M. E., Anany, M., & Mahmoud, A. M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115260 · Cited by 7
Dietary gluten worsens hepatic steatosis by increasing inflammation and oxidative stress in ApoE−/− mice fed a high-fat diet
Aguilar, E. C., Fernandes‐Braga, W., Leocádio, P. C. L., Campos, G. P., Lemos, V. S., de Oliveira, R. P., Faria, A. M. C., Capettini, L. D. S. A., & Alvarez-Leite, J. I. (2023) · Food & Function · doi:10.1039/d3fo00149k · Cited by 8
Curcumin combined with Baicalin attenuated ethanol-induced hepatitis by suppressing p38 MAPK and TSC1/ eIF-2α/ATF4 pathways in rats
Wang, X., Chang, X., Zhan, H., Li, C., Zhang, Q., Li, S., & Sun, Y. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100851 · Cited by 7
Site‐specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol‐induced liver injury
Kriss, C. L., Duro, N. D., Nadeau, O. W., Guergues, J., Chiang, O. C., Culver‐Cochran, A. E., Chaput, D., Varma, S., & Stevens, S. M. (2021) · Journal of Mass Spectrometry · doi:10.1002/jms.4713 · Cited by 7
Pathophysiology of Alcoholic Liver Disease
Nieto, N., & Rojkind, M. (2009) · Wiley eBooks · doi:10.1002/9780470747919.ch46 · Cited by 7
Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol‐associated liver injury
Watson, W. H., Ritzenthaler, J. D., Torres-González, E., Arteel, G. E., & Roman, J. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14893 · Cited by 6
Self-citation
Hepatoprotective ability of tetramethylpyrazine produced by Bacillus amyloliquefaciens
Zhang, W., Si, G., Rao, Z., Zong, S., Li, J., Zhang, X., Gao, C., Ping, Z., & Ye, M. (2020) · Systems Microbiology and Biomanufacturing · doi:10.1007/s43393-020-00018-4 · Cited by 6
Appraisal of the Antioxidative Potential of Aloe Barbadensis M. on Alcohol-Induced Oxidative Stress
Akinloye, D. I., Ugbaja, R. N., & Dosumu, O. A. (2019) · Folia veterinaria · doi:10.2478/fv-2019-0025 · Cited by 6

Authors: McKim, S. E., Gäbele, E., Isayama, F., Lambert, J. C., Tucker, L. M., Wheeler, M. D., Connor, H. D., Mason, R. P., Doll, M. A., Hein, D. W., & Arteel, G. E.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Louisville (US)
National Institutes of Health (US)
Corresponding author: Arteel, Gavin E
ORCID: Lambert, Jason C
Mason, Ronald P
Hein, David W
Arteel, Gavin E
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2003-12
Volume: 125
Issue: 6
Pages: 1834-1844
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2003.08.030
OpenAlex: W1977679256
Cited by: 243
References: 55
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 17 · 2016: 17 · 2015: 13 · 2014: 16 · 2013: 9 · 2012: 11
FWCI: 7.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: inducible nitric oxide synthase, alcohol-induced liver injury, ethanol-induced hepatotoxicity, nitric oxide, oxidative stress, peroxynitrite, 4-hydroxynonenal, nitrotyrosine, lipid peroxidation, reactive nitrogen species, NOS2 knockout mice, 1400W, hepatic steatosis, liver necrosis
MeSH terms: Alanine Transaminase, Ethanol, Aldehydes, Animals, Aspartate Aminotransferases, Body Weight, Endotoxins, Free Radicals, Liver, Mice, Inbred C57BL, RNA, Messenger, Tumor Necrosis Factor-alpha, Tyrosine, Mice, Knockout, Nitric Oxide Synthase, Cytochrome P-450 CYP2E1, Mice, Nitric Oxide Synthase Type II

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Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice

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