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Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice
Open accessAbstract
Background & aims Effective therapeutics for treating acute colitis, caused by disruption of the intestinal epithelial barrier, are scarce. Trefoil factors (TFF) are cytoprotective and promote epithelial wound healing and reconstitution of the gastrointestinal tract, which makes them good candidate therapeutics for acute colitis. However, orally administered TFF stick to the mucus of the small intestine and are absorbed at the cecum.Methods We have engineered the food-grade bacterium Lactococcus lactis to secrete bioactive murine TFF. The protective and therapeutic potentials of these TFF-secreting L. lactis were evaluated in parallel with purified TFF in the dextran sodium sulfate (DSS)-induced murine model for acute colitis and in established chronic colitis in interleukin (IL)-10(-/-) mice. Disease was evaluated by blinded macroscopic and microscopic inflammatory scores and by myeloperoxidase activity.Results Intragastric administration of TFF-secreting L. lactis led to active delivery of TFF at the mucosa of the colon and, in contrast to administration of purified TFF, proved to be very effective in prevention and healing of acute DSS-induced colitis. The in situ secreted murine TFF significantly decreased morbidity and mortality and stimulated prostaglandin-endoperoxide synthase 2 expression, which represents a major therapeutic pathway. In addition, this approach was successful in improving established chronic colitis in IL-10(-/-) mice.Conclusions We have positively evaluated a new therapeutic approach for acute and chronic colitis that involves in situ secretion of murine TFF by orally administered L. lactis. This novel approach may lead to effective management of acute and chronic colitis and epithelial damage in humans.
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“Instead of traditional orogastric administration of TFF, which sticks to the mucus layer in the small bowel preventing its localization in the colon, use of the recombinant bacterium enables delivery of TFF directly to the colonic mucosa and results in amelioration of DSS-induced disease in mice.123”
From Probiotics and the gut microbiota in intestinal health and disease (2010) · cites this paper as [123]
In the citing paper
“Instead of traditional orogastric administration of TFF, which sticks to the mucus layer in the small bowel preventing its localization in the colon, use of the recombinant bacterium enables delivery of TFF directly to the colonic mucosa and results in amelioration of DSS-induced disease in mice.123”
From Probiotics and the gut microbiota in intestinal health and disease (2010) · cites this paper as [123]
In the citing paper
“Instead of traditional orogastric administration of TFF, which sticks to the mucus layer in the small bowel preventing its localization in the colon, use of the recombinant bacterium enables delivery of TFF directly to the colonic mucosa and results in amelioration of DSS-induced disease in mice.123”
From Probiotics and the gut microbiota in intestinal health and disease (2010) · cites this paper as [123]
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Cites
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
Bradley, P. P., Priebat, D. A., Christensen, R. D., & Rothstein, G. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12506462 · Cited by 3,628
Okayasu, I., Hatakeyama, S., Yamada, M., Ohkusa, T., Inagaki, Y., & NAKAYA, R. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90290-h · Cited by 2,408
The immunological and genetic basis of inflammatory bowel disease
Bouma, G., & Strober, W. (2003) · Nature reviews. Immunology · doi:10.1038/nri1132 · Cited by 1,796
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
Self-citationSingle-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides
Stemmer, W. P. C., Crameri, A., Ha, K. D., Brennan, T. M., & Heyneker, H. L. (1995) · Gene · doi:10.1016/0378-1119(95)00511-4 · Cited by 732
Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor
Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702
Trefoil factors: initiators of mucosal healing
Taupin, D. R., & Podolsky, D. K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1203 · Cited by 643
Research works printed but not linked: 2
- Rosenberg, 1997, Epithelial cell kinase-B61, Am J Physiol, 273, G824
- Ehrlich, 1998, Peptidergic and cholinergic neurons and mediators in peptone-induced gastroprotection, Am J Physiol, 274, G955
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Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786
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Wells, J. M., & Mercenier, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1840 · Cited by 542
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Caballero‐Franco, C., Keller, K., Simone, C. D., & Chadee, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2006 · Cited by 513
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Praveschotinunt, P., Duraj‐Thatte, A., Gelfat, I., Bahl, F., Chou, D. B., & Joshi, N. S. (2019) · Nature Communications · doi:10.1038/s41467-019-13336-6 · Cited by 467
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Riglar, D. T., & Silver, P. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.172 · Cited by 460
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Kelly, D., Conway, S., & Aminov, R. I. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.008 · Cited by 394
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Corthésy, B., Gaskins, H. R., & Mercenier, A. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.781s · Cited by 353
Probiotics: Properties, Examples, and Specific ApplicationsPreprint
Behnsen, J., Deriu, E., Sassone‐Corsi, M., & Raffatellu, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a010074 · Cited by 305
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Lautenschläger, C., Schmidt, C., Fischer, D., & Stallmach, A. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.10.001 · Cited by 287
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Vandenbroucke, K., de Haard, H., Beirnaert, E., Dreier, T., Lauwereys, M., Huyck, L., Huysse, J. V., Demetter, P., Steidler, L., Remaut, E., et al. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.116 · Cited by 289
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Kucharzik, T. F., Maaser, C., Lügering, A., Kagnoff, M. F., Mayer, L., Targan, S. R., & Domschke, W. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235827.21778.d5 · Cited by 254
Zhang, S., Langer, R., & Traverso, G. (2017) · Nano Today · doi:10.1016/j.nantod.2017.08.006 · Cited by 258
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Durán‐Lobato, M., Niu, Z., & Alonso, M. J. (2019) · Advanced Materials · doi:10.1002/adma.201901935 · Cited by 252
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Anand, R., Leaphart, C. L., Mollen, K. P., & Hackam, D. J. (2007) · Shock · doi:10.1097/01.shk.0000239774.02904.65 · Cited by 232
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Yang, M., Gu, Y., Li, L., Liu, T., Song, X., Sun, Y., Cao, X., Wang, B., Jiang, K., & Cao, H. (2021) · Nutrients · doi:10.3390/nu13093143 · Cited by 223
Hoffmann, W. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5481-9 · Cited by 212
Carroll, I. M., Andrus, J. M., Bruno-Bárcena, J. M., Klaenhammer, T. R., Hassan, H. M., & Threadgill, D. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00132.2007 · Cited by 208
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Aihara, E., Engevik, K. A., & Montrose, M. H. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105447 · Cited by 201
Takiishi, T., Korf, H., Belle, T. L. V., Robert, S., Grieco, F. A., Caluwaerts, S., Galleri, L., Spagnuolo, I., Steidler, L., Huynegem, K. V., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60530 · Cited by 210
Self-citationPrebiotics and other microbial substrates for gut functionality
Ouwehand, A. C., Derrien, M., de Vos, W., Tiihonen, K., & Rautonen, N. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.01.007 · Cited by 192
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Zou, Z., Du, Y., Fang, T.-T., Zhou, Y. Q., & Ye, B. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.12.004 · Cited by 161
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Limaye, S. A., Haddad, R. I., Cilli, F., Sonis, S. T., Colevas, A. D., Brennan, M. T., Hu, K. S., & Murphy, B. A. (2013) · Cancer · doi:10.1002/cncr.28365 · Cited by 131
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Guo, W., Zhang, C., Wang, X., Dou, D., Chen, D., & Li, J. (2021) · JCI Insight · doi:10.1172/jci.insight.152616 · Cited by 101
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Landry, B. P., & Tabor, J. J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0020-2017 · Cited by 95
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Zhu, L., Lu, X., Liu, L., Voglmeir, J., Zhong, X., & Yu, Q. (2020) · Veterinary Research · doi:10.1186/s13567-020-00755-3 · Cited by 90
Mazzolini, R., Rodríguez-Arce, I., Fernández‐Barat, L., Piñero‐Lambea, C., Garrido, V., Rebollada‐Merino, A., Motos, A., Torres, A., Grilló, M. J., Serrano, L. G., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01584-9 · Cited by 90
Huibregtse, I. L., Marietta, E. V., Rashtak, S., Koning, F., Rottiers, P., David, C. S., van Deventer, S. J. H., & Murray, J. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802891 · Cited by 88
Self-citationBernasconi, E., Favre, L., Maillard, M. H., Bachmann, D., Pythoud, C., Bouzourène, H., Croze, E., Velichko, S., Parkinson, J. F., Michetti, P., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21072 · Cited by 80
Shanahan, F. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00421.2004 · Cited by 82
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Shigemori, S., Watanabe, T., Kudoh, K., Ihara, M., Nigar, S., Yamamoto, Y., Suda, Y., Sato, T., Kitazawa, H., & Shimosato, T. (2015) · Microbial Cell Factories · doi:10.1186/s12934-015-0378-2 · Cited by 78
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Rupa, P., & Mine, Y. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301903t · Cited by 80
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de LeBlanc, A. D. M., del Carmen, S., Chatel, J., Miyoshi, A., Azevedo, V., Langella, P., Bermúdez‐Humarán, L. G., & LeBlanc, J. G. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/146972 · Cited by 72
Hartwig, O., Boushehri, M. A. S., Shalaby, K. S., Loretz, B., Lamprecht, A., & Lehr, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113828 · Cited by 72
Gil‐Guerrero, L., Dotor, J., Huibregtse, I. L., Casares, N., López-Vázquez, A. B., Rudilla, F., Riezu‐Boj, J. I., López‐Sagaseta, J., Hermida, J., van Deventer, S. J. H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.126 · Cited by 68
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Rieder, F., Karrasch, T., Ben‐Horin, S., Schirbel, A., Ehehalt, R., Wehkamp, J., de Haar, C. G., Velin, D., Latella, G., Scaldaferri, F., et al. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.11.009 · Cited by 66
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Termont, S., Vandenbroucke, K., Iserentant, D., Neirynck, S., Steidler, L., Remaut, E., & Rottiers, P. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01388-06 · Cited by 61
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Metadata
- Authors
- Vandenbroucke, K., Hans, W., Van Huysse, J., Neirynck, S., Demetter, P., Remaut, E., Rottiers, P., & Steidler, L.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- University College Cork (IE)
- Ghent University Hospital (BE)
- Corresponding author
- Steidler, Lothar
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 127
- Issue
- 2
- Pages
- 502-513
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2116185627
- Cited by
- 277
- References
- 50
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 13 · 2020: 17 · 2019: 9 · 2018: 14 · 2017: 7 · 2016: 4 · 2015: 13 · 2014: 9 · 2013: 13 · 2012: 8
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- trefoil factor, Lactococcus lactis, acute colitis, chronic colitis, IL-10 knockout mice, DSS-induced colitis, epithelial repair, intestinal epithelial barrier, cyclooxygenase-2, mucosal protection, engineered bacteria
- MeSH terms
- Trefoil Factor-2, Trefoil Factor-3, Acute Disease, Administration, Oral, Animals, Chronic Disease, Colitis, Female, Isoenzymes, Mice, Inbred BALB C, Mucins, Muscle Proteins, Neuropeptides, Peptides, Prostaglandin-Endoperoxide Synthases, Recombinant Proteins, Lactococcus lactis, Wound Healing, Genetic Therapy, Gene Expression Regulation, Enzymologic, Mice, Cyclooxygenase 2, In Vitro Techniques
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