Immunomodulation by commensal and probiotic bacteria

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584 · see citing works

Treatment of Murine Colitis by <i>Lactococcus lactis</i> Secreting Interleukin-10

Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513 · see citing works

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial

Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147 · see citing works

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

Tang, Q., & Bluestone, J. A. (2008) · Nature Immunology · doi:10.1038/ni1572 · Cited by 1,026 · see citing works

Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells

Christensen, H. R., Frøkiær, H., & Pestka, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.171 · Cited by 905 · see citing works

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

Bansal, T., Alaniz, R. C., Wood, T. K., & Jayaraman, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906112107 · Cited by 868 · see citing works

Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome

Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799 · see citing works

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793 · see citing works

A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease

Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786 · see citing works

Selective probiotic bacteria induce IL-10–producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin

Smits, H. H., Engering, A. J., van der Kleij, D., de Jong, E. C., Schipper, K., van Capel, T. M. M., Zaat, B. A. J., Yazdanbakhsh, M., Wierenga, E. A., & van Kooyk, Y. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.03.036 · Cited by 765 · see citing works

Inter-kingdom signalling: Communication between bacteria and their hosts

Hughes, D. T., & Sperandio, V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1836 · Cited by 761 · see citing works

Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J. S., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 748 · see citing works

Host-Pathogen Interactions: Basic Concepts of Microbial Commensalism, Colonization, Infection, and Disease

Casadevall, A., & Pirofski, L. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.6511-6518.2000 · Cited by 617 · see citing works

Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora

Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., & Honjo, T. (2002) · Science · doi:10.1126/science.1077336 · Cited by 590 · see citing works

Secreted bioactive factors from <i>Bifidobacterium infantis</i> enhance epithelial cell barrier function

Ewaschuk, J. B., Diaz, H., Meddings, L., Diederichs, B., Dmytrash, A., Backer, J., Looijer-van Langen, M., & Madsen, K. L. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90227.2008 · Cited by 590 · see citing works

Modulation of human dendritic cell phenotype and function by probiotic bacteria

Hart, A. L., Lammers, K., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M., Kamm, M. A., Knight, S. C., & Stagg, A. J. (2004) · Gut · doi:10.1136/gut.2003.037325 · Cited by 555 · see citing works

Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria

Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553 · see citing works

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

Zuany‐Amorim, C., Sawicka, E., Manlius, C., Moine, A. L., Brunet, L. R., Kemeny, D. M., Bowen, G., Rook, G. A. W., & Walker, C. (2002) · Nature Medicine · doi:10.1038/nm0602-625 · Cited by 514 · see citing works

The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products

Bowie, A., & O'Neill, L. A. J. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.4.508 · Cited by 495 · see citing works

Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis

Mennigen, R. B., Nolte, K., Rijcken, E. J. M., Utech, M., Loeffler, B., Senninger, N. J., & Bruewer, M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90534.2008 · Cited by 484 · see citing works

Mucosal Immunity: Induction, Dissemination, and Effector Functions

Brandtzaeg, P. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02319.x · Cited by 483 · see citing works

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482 · see citing works

Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization

Mohamadzadeh, M., Olson, S. D., Kalina, W. V., Ruthel, G. T., Demmin, G. L., Warfield, K. L., Bavari, S., & Klaenhammer, T. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500098102 · Cited by 465 · see citing works

Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance

McCarthy, J., O’Mahony, L., O’Callaghan, L., Sheil, B., Vaughan, E. E., Fitzsimons, N., Fitzgibbon, J., O’Sullivan, G. C., Kiely, B., Collins, J. K., et al. (2003) · Gut · doi:10.1136/gut.52.7.975 · Cited by 462 · see citing works

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

Grangette, C., Nutten, S., Palumbo, E., Morath, S., Hermann, C., Dewulf, J., Pot, B., Härtung, T., Pascal Hols, A., & Mercenier, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504084102 · Cited by 443 · see citing works

The Pseudomonas aeruginosa Quorum-Sensing Signal Molecule N -(3-Oxododecanoyl)- l -Homoserine Lactone Has Immunomodulatory Activity

Telford, G., Wheeler, D., Williams, P. M., et al. (1998) · Infection and Immunity · doi:10.1128/iai.66.1.36-42.1998 · Cited by 425 · see citing works

Effects of probiotics on atopic dermatitis: a randomised controlled trial

Weston, S. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.060673 · Cited by 408 · see citing works

The Vagus Nerve: A Tonic Inhibitory Influence Associated With Inflammatory Bowel Disease in a Murine Model

Ghia, J., Blennerhassett, P. A., Kumar–Ondiveeran, H., Verdu, E. F., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.016 · Cited by 404 · see citing works

THE ENTERIC NERVOUS SYSTEM AND REGULATION OF INTESTINAL MOTILITY

Kunze, W., & Furness, J. B. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.117 · Cited by 403 · see citing works

Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria

Miettinen, M., Vuopio‐Varkila, J., & Varkila, K. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5403-5405.1996 · Cited by 402 · see citing works

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation

O’Mahony, C., Scully, P., O'Mahony, D., Murphy, S., O'Brien, F., Lyons, A., Sherlock, G., MacSharry, J. A., Kiely, B., Shanahan, F., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000112 · Cited by 365 · see citing works

Lactobacillus reuteri –induced Regulatory T cells Protect against an Allergic Airway Response in Mice

Karimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-951oc · Cited by 361 · see citing works

Probiotic‐induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory‐dependent mechanisms in a murine model of asthma

Feleszko, W., Jaworska, J., Rha, R.-D., Steinhausen, S., Avagyan, A., Jaudszus, A., Ahrens, B., Groneberg, D. A., Wahn, U., & Hamelmann, E. H. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02629.x · Cited by 339 · see citing works

<i>Lactobacillus reuteri</i> enhances excitability of colonic AH neurons by inhibiting calcium‐dependent potassium channel opening

Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328 · see citing works

Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains

Maassen, C. B. M., van Holten-Neelen, C., Balk, F. R. M., Bak‐Glashouwer, M. ‐. H. D., Leer, R. J., Laman, J. D., Boersma, W. J. A., & Claassen, E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00378-3 · Cited by 326 · see citing works

Oral Treatment with Live Lactobacillus reuteri Inhibits the Allergic Airway Response in Mice

Forsythe, P., Inman, M. D., & Bienenstock, J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200606-821oc · Cited by 306 · see citing works

Live Lactobacillus reuteri Is Essential for the Inhibitory Effect on Tumor Necrosis Factor Alpha-Induced Interleukin-8 Expression

Ma, D., Forsythe, P., & Bienenstock, J. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5308-5314.2004 · Cited by 289 · see citing works

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

Vandenbroucke, K., de Haard, H., Beirnaert, E., Dreier, T., Lauwereys, M., Huyck, L., Huysse, J. V., Demetter, P., Steidler, L., Remaut, E., et al. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.116 · Cited by 289 · see citing works

A Key Role of Dendritic Cells in Probiotic Functionality

Foligné, B., Ζουμποπούλου, Γ., Dewulf, J., Younes‐Chennoufi, A. B., Chareyre, F., Sirard, J., Pot, B., & Grangette, C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000313 · Cited by 278 · see citing works

Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice

Vandenbroucke, K., Hans, W., Van Huysse, J., Neirynck, S., Demetter, P., Remaut, E., Rottiers, P., & Steidler, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.020 · Cited by 277 · see citing works

Probiotic bacteria down‐regulate the milk‐induced inflammatory response in milk‐hypersensitive subjects but have an immunostimulatory effect in healthy subjects

Pelto, Isolauri, Lilius, Nuutila, & Salminen (1998) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1998.00449.x · Cited by 275 · see citing works

Foxp3 and Natural Regulatory T Cells

Ramsdell, F. (2003) · Immunity · doi:10.1016/s1074-7613(03)00207-3 · Cited by 275 · see citing works

Effect of perorally administered lactobacilli on macrophage activation in mice

Perdigón, G., de Macias, M. E. N., Alvarez, S., Oliver, G. D., & Holgado, A. A. D. R. (1986) · Infection and Immunity · doi:10.1128/iai.53.2.404-410.1986 · Cited by 265 · see citing works

Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease

Abad, C., Martínez, C., Juarranz, M. G., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50141 · Cited by 257 · see citing works

Systemic augmentation of the immune response in mice by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus.

Perdigón, G., de Macias, M. E. N., Alvarez, S., Oliver, G. D., & Holgado, A. P. D. R. (1988) · PubMed Central · Cited by 237 · see citing works

Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function

Braat, H., van den Brande, J., van Tol, E., Hommes, D. W., Peppelenbosch, M. P., & van Deventer, S. J. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1618 · Cited by 235 · see citing works

Lactobacilli as live vaccine delivery vectors: progress and prospects

Seegers, J. F. M. L. (2002) · Trends in biotechnology · doi:10.1016/s0167-7799(02)02075-9 · Cited by 226 · see citing works

A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials

Boge, T., Remigy, M., Vaudaine, S., Tanguy, J., Bourdet‐Sicard, R., & van der Werf, S. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.06.094 · Cited by 221 · see citing works

Regulatory T Cells in Allergy and Asthma

Larché, M. (2007) · CHEST Journal · doi:10.1378/chest.06-2434 · Cited by 210 · see citing works

Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains ofLactococcus lactisCoexpressing Antigen and Cytokine

Steidler, L., Robinson, K., Chamberlain, L. M., Schofield, K. M., Remaut, E., Page, R. W. F. L., & Wells, J. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.7.3183-3189.1998 · Cited by 208 · see citing works

Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis

Khailova, L. S., Dvorak, K., Arganbright, K. M., Halpern, M. D., Kinouchi, T., Yajima, M., & Dvořák, B. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00141.2009 · Cited by 199 · see citing works

Lactobacillus rhamnosus GG decreases TNF-alpha production in lipopolysaccharide-activated murine macrophages by a contact-independent mechanism

Peña, J. A., & Versalovic, J. A. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.t01-1-00275.x · Cited by 194 · see citing works

The role of mast cells in inflammatory processes: evidence for nerve/mast cell interactions

Bienenstock, J., Tomioka, M., Matsuda, H., Stead, R. H., Quinonez, G., Simon, G. T., Coughlin, M. D., & Denburg, J. A. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234197 · Cited by 193 · see citing works

Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction

Verdú, E. F., Bercík, P., Bergonzelli, G. E., Huang, X.-X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthésy-Theulaz, I., & Collins, S. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.007 · Cited by 180 · see citing works

Relationship between interaction sites in the gut, hydrophobicity, mucosal immunomodulating capacities and cell wall protein profiles in indigenous and exogenous bacteria

Vinderola, C. G., Medici, M., & Perdigón, G. (2004) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2004.02158.x · Cited by 174 · see citing works

Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway

Hoarau, C., Lagaraine, C., Martin, L., Velge-Roussel, F., & Lebranchu, Y. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.10.043 · Cited by 171 · see citing works

Bifidobacterium longum lysate, a new ingredient for reactive skin

Guéniche, A., Bastien, P., Ovigne, J.-M., Kermici, M., Courchay, G., Chevalier, V., Breton, L., & Castiel‐Higounenc, I. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00932.x · Cited by 169 · see citing works

Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring

Blümer, N., Sel, S., Virna, S., Patrascan, C. C., Zimmermann, S., Herz, U., Renz, H. E., & Garn, H. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02671.x · Cited by 168 · see citing works

Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases

Delgado, M., Abad, C., Martínez, C., et al. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0291-5 · Cited by 162 · see citing works

Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials

Vliagoftis, H., Kouranos, V., Betsi, G. I., & Falagas, M. E. (2008) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60219-0 · Cited by 146 · see citing works

Immunomodulatory function of lactic acid bacteria

Yasui, H., Shida, K., Matsuzaki, T., & Yokokura, T. (1999) · Springer eBooks · doi:10.1007/978-94-017-2027-4_24 · Cited by 126 · see citing works

Use of Green Fluorescent Protein To Tag Lactic Acid Bacterium Strains under Development as Live Vaccine Vectors

Geoffroy, M.-C., Guyard, C., Quatannens, B., et al. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.1.383-391.2000 · Cited by 121 · see citing works

Lactobacillus Acidophilus Strain L-92 Regulates the Production of Th1 Cytokine as well as Th2 Cytokines

Torii, A., Torii, S., Fujiwara, S., Tanaka, H., Inagaki, N., & Nagai, H. (2007) · Allergology International · doi:10.2332/allergolint.o-06-459 · Cited by 119 · see citing works

Regulation of IgA synthesis at mucosal surfaces

Fagarasan, S., & Honjo, T. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.03.005 · Cited by 113 · see citing works

Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo

Delgado, M., Chorny, A., González‐Rey, E., et al. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605299 · Cited by 112 · see citing works

Calcitonin Gene-Related Peptide Decreases Expression of HLA-DR and CD86 by Human Dendritic Cells and Dampens Dendritic Cell-Driven T Cell-Proliferative Responses Via the Type I Calcitonin Gene-Related Peptide Receptor

Carucci, J. A., Ignatius, R., Wei, Y., Cypess, A. M., Schaer, D., Pope, M., Steinman, R. M., & Mojsov, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3494 · Cited by 109 · see citing works

Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat

Fritz, J. H., Bourhis, L. L., Magalhaes, J. G., & Philpott, D. J. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.10.002 · Cited by 106 · see citing works

Modification of In Vivo and In Vitro T- and B-Cell-Mediated Immune Responses by the Pseudomonas aeruginosa Quorum-Sensing Molecule N -(3-Oxododecanoyl)- l -Homoserine Lactone

Ritchie, A. J., Yam, A. O. W., Tanabe, K. M., et al. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4421-4431.2003 · Cited by 106 · see citing works

Immunomodulatory function of lactic acid bacteria

Yasui, H., Shida, K., Matsuzaki, T., & Yokokura, T. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002041616085 · Cited by 106 · see citing works

Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans

O’Mahony, L., O'Callaghan, L., McCarthy, J., Shilling, D., Scully, P., Sibartie, S., Kavanagh, E. K., Kirwan, W. O., Redmond, H. P., Collins, J. K., et al. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00112.2005 · Cited by 104 · see citing works

Epithelial Cells and Their Neighbors. IV. Bacterial contributions to intestinal epithelial barrier integrity

Ismail, A. S., & Hooper, L. V. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2005 · Cited by 103 · see citing works

Loss of vagal anti-inflammatory effect: in vivo visualization and adoptive transfer

O’Mahony, C., van der Kleij, H. P. M., Bienenstock, J., Shanahan, F., & O’Mahony, L. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90904.2008 · Cited by 102 · see citing works

Neuromodulation of enteropathogen internalization in Peyer's patches from porcine jejunum

Green, B. T., Lyte, M., Kulkarni, A. P., & Brown, D. R. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00225-x · Cited by 98 · see citing works

Growth phase of orally administered Lactobacillus strains differentially affects IgG1/IgG2a ratio for soluble antigens: implications for vaccine development

Maassen, C. B. M., Boersma, W. J. A., van Holten-Neelen, C., Claassen, E., & Laman, J. D. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00220-2 · Cited by 96 · see citing works

CD4 + Foxp3 + regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells

Westendorf, A. M., Fleissner, D., Groebe, L., Jung, S., Gruber, A. D., Hansen, W., & Buer, J. (2008) · Gut · doi:10.1136/gut.2008.151720 · Cited by 95 · see citing works

Supernatant from Bifidobacterium Differentially Modulates Transduction Signaling Pathways for Biological Functions of Human Dendritic Cells

Hoarau, C., Martin, L., Faugaret, D., Baron, C., Dauba, A., Aubert‐Jacquin, C., Velge-Roussel, F., & Lebranchu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002753 · Cited by 93 · see citing works

Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor response

Chorny, A., González‐Rey, E., Fernandez‐Martin, A., et al. (2006) · Blood · doi:10.1182/blood-2005-11-4495 · Cited by 91 · see citing works

Epithelial Expression of HLA, Secretory Component (Poly‐Ig Receptor), and Adhesion Molecules in the Human Alimentary Tracta

Brandtzæg, P., Halstensen, T. S., Huitfeldt, H. S., et al. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb39758.x · Cited by 89 · see citing works

Effect of the administration of a fermented milk containing Lactobacillus casei DN-114001 on intestinal microbiota and gut associated immune cells of nursing mice and after weaning until immune maturity

de LeBlanc, A. D. M., Dogi, C. A., Galdeano, C. M., Carmuega, E., Weill, R., & Perdigón, G. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-27 · Cited by 86 · see citing works

Gut Microbiota and Probiotics in Modulation of Epithelium and Gut-Associated Lymphoid Tissue Function

Sanz, Y., & Palma, G. D. (2009) · International Reviews of Immunology · doi:10.3109/08830180903215613 · Cited by 86 · see citing works

The vagus nerve modulates CD4+ T cell activity

Karimi, K., Bienenstock, J., Wang, L., & Forsythe, P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.016 · Cited by 79 · see citing works

Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis

Tsuji, M., Suzuki, K., Kinoshita, K., & Fagarasan, S. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.12.003 · Cited by 77 · see citing works

Toll-like receptors and microbes take aim at each other

Underhill, D. M. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.05.012 · Cited by 71 · see citing works

Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve

van der Kleij, H. P. M., O’Mahony, C., Shanahan, F., O’Mahony, L., & Bienenstock, J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90434.2008 · Cited by 70 · see citing works

Substance P augments tumor necrosis factor release in human monocyte-derived macrophages

Lee, H. R., Ho, W., & Douglas, S. D. (1994) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.1.4.419-423.1994 · Cited by 69 · see citing works

Anatomical evidence for enteric neuroimmune interactions in Peyer’s patches

Vulchanova, L., Casey, M. A., Wendelschafer‐Crabb, G., Kennedy, W. R., & Brown, D. R. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.01.014 · Cited by 66 · see citing works

Influences of enteral nutrition combined with probiotics on gut microflora and barrier function of rats with abdominal infection

Shen, T. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i27.4352 · Cited by 63 · see citing works

Interaction of bifidobacteria with the gut and their influence in the immune function

Perdig髇, G., Locascio, M., Medici, M., Holagado, A. P. D. R., & Oliver, G. (2003) · Biocell · doi:10.32604/biocell.2003.27.001 · Cited by 54 · see citing works

Importance of the host specificity in the selection of probiotic bacteria

Dogi, C. A., & Perdigón, G. (2006) · Journal of Dairy Research · doi:10.1017/s0022029906001993 · Cited by 53 · see citing works

Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis

Boontham, P., Robins, A., Chandran, P., et al. (2008) · Clinical Science · doi:10.1042/cs20080018 · Cited by 52 · see citing works

Pre and probiotics in the prevention and treatment of food allergy

Savilahti, E., Kuitunen, M., & Vaarala, O. (2008) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3282ffb134 · Cited by 52 · see citing works

Oral delivery of foreign antigens by attenuated Salmonella: consequences of prior exposure to the vector strain

Attridge, S. R., Davies, R. C., & LaBrooy, J. T. (1997) · Vaccine · doi:10.1016/s0264-410x(96)00158-2 · Cited by 50 · see citing works

Vasoactive intestinal polypeptide modulates the in vitro immunoglobulin a production by intestinal lamina propria lymphocytes

Boirivant, M., Fais, S., Annibale, B., et al. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90688-2 · Cited by 44 · see citing works

Dendritic Cells from Peyer’s Patches and Mesenteric Lymph Nodes Differ from Spleen Dendritic Cells in their Response to Commensal Gut Bacteria

Fink, L. N., & Frøkiær, H. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02136.x · Cited by 44 · see citing works

Mucosal Adjuvants

Stevceva, L., & Ferrari, M. G. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381846 · Cited by 36 · see citing works

Factors that regulate naturally occurring T regulatory cell–mediated suppression

Goleva, E., Cardona, I. D., Ou, L.-S., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.051 · Cited by 35 · see citing works

Vasoactive Intestinal Peptide

Delgado, M., González‐Rey, E., & Ganea, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1317.020 · Cited by 32 · see citing works

Intestinal epithelial barrier and mucosal immunity

Alexopoulou, L., & Kontoyiannis, D. L. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5039-x · Cited by 31 · see citing works

Intestinal neuro-epithelial interactions modulate neuronal chemokines production

Tixier, E., Galmiche, J., & Neunlist, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.159 · Cited by 28 · see citing works

Role of neuropeptides, nerves and mast cells in intestinal immunity and physiology.

Bienenstock, J., Denburg, J., Scicchitano, R., et al. (1988) · PubMed · Cited by 21 · see citing works

Regulatory effects of vasoactive intestinal peptide on the migration of mature dendritic cells

Weng, Y., Sun, J., Wu, Q., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.09.009 · Cited by 20 · see citing works

Nerves and Neuropeptides in the Regulation of Mucosal Immunity

Bienenstock, J., Croitoru, K., Ernst, P. B., et al. (1989) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5712-4_4 · Cited by 18 · see citing works

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

Leclercq, S., Matamoros, S., Cani, P. D., Neyrinck, A. M., Jamar, F., Stärkel, P., Windey, K., Tremaroli, V., Bäckhed, F., Verbeke, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415174111 · Cited by 972 · see citing works

The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality

Montiel-Castro, A. J., González-Cervantes, R. M., Bravo-Ruiseco, G., & Pacheco-López, G. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00070 · Cited by 413 · see citing works

The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective

Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works

Microbiota-gut-brain axis and the central nervous system

Zhu, X., Han, Y., Du, J., Liu, R., Jin, K., & Yi, W. (2017) · Oncotarget · doi:10.18632/oncotarget.17754 · Cited by 308 · see citing works

Cancer-promoting effects of microbial dysbiosis

Sheflin, A. M., Whitney, A. K., & Weir, T. L. (2014) · Current Oncology Reports · doi:10.1007/s11912-014-0406-0 · Cited by 301 · see citing works

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

O’Mahony, S. M., Felice, V. D., Nally, K., Savignac, H. M., Claesson, M. J., Scully, P., Woznicki, J., Hyland, N. P., Shanahan, F., Quigley, E. M., et al. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.054 · Cited by 272 · see citing works

Psychoactive bacteria <i>Lactobacillus rhamnosus</i> (JB-1) elicits rapid frequency facilitation in vagal afferents

Perez-Burgos, A., Wang, B., Mao, Y.-K., Mistry, B., Neufeld, K.-A. M., Bienenstock, J., & Kunze, W. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00128.2012 · Cited by 235 · see citing works

Probiotic <i>Lactobacillus</i> Strains Stimulate the Inflammatory Response and Activate Human Macrophages

Rocha-Ramírez, L. M., Pérez-Solano, R. A., Castañón-Alonso, S. L., Moreno Guerrero, S. S., Ramírez Pacheco, A., García Garibay, M., & Eslava, C. (2017) · Journal of Immunology Research · doi:10.1155/2017/4607491 · Cited by 227 · see citing works

Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions

Ristori, M. V., Quagliariello, A., Reddel, S., Ianiro, G., Vicari, S., Gasbarrini, A., & Putignani, L. (2019) · Nutrients · doi:10.3390/nu11112812 · Cited by 214 · see citing works

Inflammation, Sanitation, and Consternation: Loss of Contact With Coevolved, Tolerogenic Microorganisms and the Pathophysiology and Treatment of Major Depression

Raison, C. L., Lowry, C. A., & Rook, G. A. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.161 · Cited by 169 · see citing works

Impact of Probiotics on Colonizing Microbiota of the Gut

Sanders, M. E. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318227414a · Cited by 153 · see citing works

Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health

Albers, R., Bourdet-Sicard, R., Braun, D., Calder, P. C., Herz, U., Lambert, C., Lenoir-Wijnkoop, I., Méheust, A., Ouwehand, A., Phothirath, P., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513001505 · Cited by 150 · see citing works

On communication between gut microbes and the brain

Forsythe, P., Kunze, W. A., & Bienenstock, J. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283572ffa · Cited by 137 · see citing works

Probiotics, mechanisms of action, and clinical perspectives for diarrhea management in children

do Carmo, M. S., Santos, C. I. D., Araújo, M. C., Girón, J. A., Fernandes, E. S., & Monteiro-Neto, V. (2018) · Food &amp; Function · doi:10.1039/c8fo00376a · Cited by 75 · see citing works

Comprehensive probiogenomics analysis of the commensal Escherichia coli CEC15 as a potential probiotic strain

da Silva, T. F., Glória, R. D. A., de Sousa, T. J., Americo, M. F., Freitas, A. D. S., Viana, M. V. C., de Jesus, L. C. L., da Silva Prado, L. C., Daniel, N., Ménard, O., et al. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03112-4 · Cited by 11 · see citing works

[The history of commensalism: a contemporary history of microbiology].

Poreau, B. (2014) · PubMed · Cited by 2 · see citing works

Bioavailability of Trace Metals

Adriano, D. C. (2001) · doi:10.1007/978-0-387-21510-5_3 · Cited by 74 · see citing works

Is absence of proof a proof of absence? Comments on commensalism

Zapalski, M. K. (2011) · Palaeogeography Palaeoclimatology Palaeoecology · doi:10.1016/j.palaeo.2011.01.013 · Cited by 101 · see citing works

Molecular commensalism—how to investigate underappreciated health-associated polymicrobial communities

Labossiere, A., Ramsey, M. M., Merritt, J. L., & Kreth, J. (2023) · mBio · doi:10.1128/mbio.01342-23 · Cited by 6 · see citing works

Competitive fungal commensalism mitigates candidiasis pathologyPreprint

Kralova, J. S., Donic, C., Dassa, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.12.575358 · Cited by 3 · see citing works