Engineering bacteria for diagnostic and therapeutic applications

Enzymatic assembly of DNA molecules up to several hundred kilobases

Gibson, D. G., Young, L., Chuang, R.-Y., Venter, J. C., Hutchison, C. A., & Smith, H. O. (2009) · Nature Methods · doi:10.1038/nmeth.1318 · Cited by 9,742 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

A synthetic oscillatory network of transcriptional regulators

Elowitz, M., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,812 · see citing works

Construction of a genetic toggle switch in Escherichia coli

Gardner, T. S., Cantor, C. R., & Collins, J. J. (2000) · Nature · doi:10.1038/35002131 · Cited by 4,310 · see citing works

Biology of Incretins: GLP-1 and GIP

Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639 · see citing works

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

Medema, M. H., Blin, K., Cimermančič, P., de Jager, V., Zakrzewski, P., Fischbach, M. A., Weber, T., Eriko Takano, A., & Rainer Breitling, A. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr466 · Cited by 2,013 · see citing works

Treatment of Murine Colitis by <i>Lactococcus lactis</i> Secreting Interleukin-10

Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513 · see citing works

Gut inflammation provides a respiratory electron acceptor for Salmonella

Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271 · see citing works

A fast, robust and tunable synthetic gene oscillator

Stricker, J., Cookson, S., Bennett, M. R., Mather, W., Tsimring, L. S., & Hasty, J. (2008) · Nature · doi:10.1038/nature07389 · Cited by 1,102 · see citing works

Genetic circuit design automation

Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D. M., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,032 · see citing works

THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

COLEY, W. B. (1893) · The American Journal of the Medical Sciences · doi:10.1097/00000441-189305000-00001 · Cited by 994 · see citing works

Bacterially Speaking

Bassler, B. L., & Losick, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.04.001 · Cited by 983 · see citing works

The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.

COLEY, W. B. (1991) · PubMed · Cited by 971 · see citing works

Genomically Recoded Organisms Expand Biological Functions

Lajoie, M. J., Rovner, A. J., Goodman, D. B., Aerni, H. R., Haimovich, A. D., Kuznetsov, G., Mercer, J. A. M., Wang, H. H., Carr, P. A., Mosberg, J. A., et al. (2013) · Science · doi:10.1126/science.1241459 · Cited by 859 · see citing works

A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells

Awasthi, A., Carrier, Y., Peron, J. P. S., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K., Oukka, M., & Weiner, H. L. (2007) · Nature Immunology · doi:10.1038/ni1541 · Cited by 804 · see citing works

Immune responses to Listeria monocytogenes

Pamer, E. G. (2004) · Nature reviews. Immunology · doi:10.1038/nri1461 · Cited by 791 · see citing works

A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease

Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786 · see citing works

Synchronized cycles of bacterial lysis for in vivo delivery

Din, M. O., Danino, T., Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, E., Tsimring, L. S., Bhatia, S. N., et al. (2016) · Nature · doi:10.1038/nature18930 · Cited by 784 · see citing works

Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice

Goodman, A. L., Kallstrom, G., Faith, J. J., Reyes, A., Moore, A. M., Dantas, G. A., & Gordon, J. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102938108 · Cited by 779 · see citing works

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

Stumhofer, J. S., Silver, J. S., Laurence, A. D. J., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J. M., O’Shea, J. J., & Hunter, C. A. (2007) · Nature Immunology · doi:10.1038/ni1537 · Cited by 777 · see citing works

Mining the Human Gut Microbiota for Immunomodulatory Organisms

Geva-Zatorsky, N., Sefik, E., Kua, L., Pasman, L., Tan, T. G., Ortiz-Lopez, A., Yanortsang, T. B., Yang, L., Jupp, R., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.022 · Cited by 762 · see citing works

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750 · see citing works

Precise and reliable gene expression via standard transcription and translation initiation elements

Mutalik, V. K., Guimaraes, J. C., Cambray, G., Lam, C. S. C., Christoffersen, M. J., Mai, Q.-A., Tran, A. B., Paull, M. L., Keasling, J. D., Arkin, A. P., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2404 · Cited by 748 · see citing works

Phase I Study of the Intravenous Administration of AttenuatedSalmonella typhimuriumto Patients With Metastatic Melanoma

Toso, J. F., Gill, V. J., Hwu, P., Marincola, F. M., Restifo, N. P., Schwartzentruber, D. J., Sherry, R. M., Topalian, S. L., Yang, J. C.-H., Stock, F., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.1.142 · Cited by 747 · see citing works

Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues

Mahan, M. J., Slauch, J. M., & Mekalanos, J. J. (1993) · Science · doi:10.1126/science.8430319 · Cited by 665 · see citing works

The QseC sensor kinase: A bacterial adrenergic receptor

Clarke, M. B., Hughes, D. T., Zhu, C., Boedeker, E. C., & Sperandio, V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604343103 · Cited by 621 · see citing works

Phase I Study of the Intravenous Administration of Attenuated Salmonella typhimurium to Patients With Metastatic Melanoma

Toso, J. F. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.1.142 · Cited by 616 · see citing works

Safety and Survival With GVAX Pancreas Prime and <i>Listeria Monocytogenes</i> –Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

Le, D. T., Wang-Gillam, A., Picozzi, V., Greten, T. F., Crocenzi, T., Springett, G., Morse, M., Zeh, H., Cohen, D., Fine, R. L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.4244 · Cited by 611 · see citing works

The bioenergetic costs of a gene

Lynch, M., & Marinov, G. K. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514974112 · Cited by 600 · see citing works

Two-step enhanced cancer immunotherapy with engineered <i>Salmonella typhimurium</i> secreting heterologous flagellin

Zheng, J. H., Nguyen, V. H., Jiang, S.-N., Park, S.-H., Tan, W., Hong, S. H., Shin, M. G., Chung, I.-J., Hong, Y., Bom, H.-S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aak9537 · Cited by 588 · see citing works

Synthetic Gene Networks That Count

Friedland, A. E., Lu, T. K., Wang, X., Shi, D., Church, G. M., & Collins, J. J. (2009) · Science · doi:10.1126/science.1172005 · Cited by 587 · see citing works

Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10

Steidler, L., Neirynck, S., Huyghebaert, N., Snoeck, V., Vermeire, A., Goddeeris, B. M., Cox, E., Remon, J. P., & Remaut, E. (2003) · Nature Biotechnology · doi:10.1038/nbt840 · Cited by 545 · see citing works

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Pickard, J. M., Maurice, C. F., Kinnebrew, M. A., Abt, M. C., Schenten, D., Golovkina, T. V., Bogatyrev, S. R., Ismagilov, R. F., Pamer, E. G., Turnbaugh, P. J., et al. (2014) · Nature · doi:10.1038/nature13823 · Cited by 535 · see citing works

Combinatorial Synthesis of Genetic Networks

Guet, C. C., Elowitz, M. B., Hsing, W., & Leibler, S. (2002) · Science · doi:10.1126/science.1067407 · Cited by 527 · see citing works

Tumor-targeted Salmonella as a novel anticancer vector.

Pawelek, J. M., Low, K. B., & Bermudes, D. G. (1997) · PubMed · Cited by 514 · see citing works

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease

Fedorak, R. N., Gangl, A., Elson, C. O., Rutgeerts, P. J., Schreiber, S., Wild, G., Hanauer, S. B., Kilian, A., Cohard, M., LeBeaut, A., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.20229 · Cited by 511 · see citing works

The outer mucus layer hosts a distinct intestinal microbial niche

Li, H., Limenitakis, J. P., Fuhrer, T., Geuking, M. B., Lawson, M. A., Wyss, M., Brugiroux, S., Keller, I., Macpherson, J. A., Rupp, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9292 · Cited by 511 · see citing works

Quantifying cellular capacity identifies gene expression designs with reduced burden

Ceroni, F., Algar, R., Stan, G.-B. V., & Ellis, T. (2015) · Nature Methods · doi:10.1038/nmeth.3339 · Cited by 491 · see citing works

A Synthetic Genetic Edge Detection Program

Tabor, J. J., Salis, H. M., Simpson, Z. B., Chevalier, A. A., Levskaya, A., Marcotte, E. M., Voigt, C. A., & Ellington, A. D. (2009) · Cell · doi:10.1016/j.cell.2009.04.048 · Cited by 485 · see citing works

Biocontainment of genetically modified organisms by synthetic protein design

Mandell, D. J., Lajoie, M. J., Mee, M. T., Takeuchi, R., Kuznetsov, G., Norville, J. E., Gregg, C. J., Stoddard, B. L., & Church, G. M. (2015) · Nature · doi:10.1038/nature14121 · Cited by 474 · see citing works

Programmable probiotics for detection of cancer in urine

Danino, T., Prindle, A. B., Kwong, G. A., Skalak, M., Li, H. Y., Allen, K. N., Hasty, J., & Bhatia, S. N. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3519 · Cited by 472 · see citing works

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

Hwang, I. Y., Koh, E., Wong, A., March, J. C., Bentley, W. E., Lee, Y. S., & Chang, M. W. (2017) · Nature Communications · doi:10.1038/ncomms15028 · Cited by 472 · see citing works

Massively parallel de novo protein design for targeted therapeutics

Chevalier, A., Silva, D.-A., Rocklin, G. J., Hicks, D. R., Vergara, R., Murapa, P., Bernard, S. M., Zhang, L., Lam, K.-H., Yao, G., et al. (2017) · Nature · doi:10.1038/nature23912 · Cited by 453 · see citing works

Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic

Curtiss, R., & Kelly, S. M. (1987) · Infection and Immunity · doi:10.1128/iai.55.12.3035-3043.1987 · Cited by 431 · see citing works

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

Wong, F. S., Karttunen, J. T., Dumont, C., Li, W., Visintin, I., Pilip, I. M., Shastri, N., Pamer, E. G., & Janeway, C. A. (1999) · Nature Medicine · doi:10.1038/12465 · Cited by 427 · see citing works

Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation

Riglar, D. T., Giessen, T. W., Baym, M., Kerns, S. J., Niederhuber, M. J., Bronson, R. T., Kotula, J. W., Gerber, G. K., Way, J. C., & Silver, P. A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3879 · Cited by 426 · see citing works

'Deadman' and 'Passcode' microbial kill switches for bacterial containment

Chan, C. T. Y., Lee, J. W., Cameron, D. E., Bashor, C. J., & Collins, J. J. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1979 · Cited by 406 · see citing works

Microbiology of bacterial translocation in humans

O’Boyle, C. J., MacFie, J., Mitchell, C. J., Johnstone, D., Sagar, P. M., & Sedman, P. C. (1998) · Gut · doi:10.1136/gut.42.1.29 · Cited by 393 · see citing works

Complex cellular logic computation using ribocomputing devices

Green, A. A., Kim, J., Ma, D., Silver, P. A., Collins, J. J., & Yin, P. (2017) · Nature · doi:10.1038/nature23271 · Cited by 392 · see citing works

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota

Mimee, M., Tucker, A. C., Voigt, C. A., & Lu, T. K. (2015) · Cell Systems · doi:10.1016/j.cels.2015.06.001 · Cited by 387 · see citing works

Burden-driven feedback control of gene expression

Ceroni, F., Boo, A., Furini, S., Gorochowski, T. E., Borkowski, O., Ladak, Y., Awan, A. R., Gilbert, C., Stan, G.-B. V., & Ellis, T. (2018) · Nature Methods · doi:10.1038/nmeth.4635 · Cited by 375 · see citing works

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

Le, D. T., Brockstedt, D. G., Nir‐Paz, R., Hampl, J., Mathur, S., Nemunaitis, J. J., Sterman, D. H., Hassan, R., Lutz, E. R., Moyer, B., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2121 · Cited by 370 · see citing works

Recoded organisms engineered to depend on synthetic amino acids

Rovner, A. J., Haimovich, A. D., Katz, S. R., Li, Z., Grome, M. W., Gassaway, B. M., Amiram, M., Patel, J. R., Gallagher, R. R., Rinehart, J., et al. (2015) · Nature · doi:10.1038/nature14095 · Cited by 366 · see citing works

Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen

Saeidi, N., Wong, C. K., Lo, T., Nguyen, H. X., Ling, H., Leong, S. S. J., Poh, C. L., & Chang, M. W. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.55 · Cited by 366 · see citing works

Programmable bacteria detect and record an environmental signal in the mammalian gut

Kotula, J. W., Kerns, S. J., Shaket, L. A., Siraj, L., Collins, J. J., Way, J. C., & Silver, P. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321321111 · Cited by 363 · see citing works

Rewritable digital data storage in live cells via engineered control of recombination directionality

Bonnet, J., Subsoontorn, P., & Endy, D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202344109 · Cited by 356 · see citing works

GoldenBraid: an iterative cloning system for standardized assembly of reusable genetic modules.

Sarrion-Perdigones, A., Falconi, E. E., Zandalinas, S. I., Juárez, P., Fernández-del-Carmen, A., Granell, A., & Orzaez, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021622 · Cited by 348 · see citing works

Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients

Nemunaitis, J. J., Cunningham, C. C., Senzer, N. N., Kuhn, J. A., Cramm, J., Litz, C. E., Cavagnolo, R. Z., Cahill, A. L., Clairmont, C., & Sznol, M. (2003) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700634 · Cited by 343 · see citing works

Discovering and improving novel peptide therapeutics

MCGREGOR, D. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.06.002 · Cited by 332 · see citing works

Recognition of Host Immune Activation by Pseudomonas aeruginosa

Wu, L., Estrada, O., Zaborina, O. Y., Bains, M., Shen, L., Kohler, J. E., Patel, N. J., Musch, M. W., Chang, E. B., Fu, Y., et al. (2005) · Science · doi:10.1126/science.1112422 · Cited by 330 · see citing works

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

Maciag, P., Radulovic, S. S., & Rothman, J. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.04.041 · Cited by 325 · see citing works

Synchronous long-term oscillations in a synthetic gene circuit

Potvin-Trottier, L., Lord, N. D., Vinnicombe, G., & Paulsson, J. (2016) · Nature · doi:10.1038/nature19841 · Cited by 308 · see citing works

Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation

Daeffler, K. N.-M., Galley, J. D., Sheth, R. U., Ortiz-Velez, L., Bibb, C. O., Shroyer, N. F., Britton, R. A., & Tabor, J. J. (2017) · Molecular Systems Biology · doi:10.15252/msb.20167416 · Cited by 302 · see citing works

Listeria -based cancer vaccines that segregate immunogenicity from toxicity

Brockstedt, D. G., Giedlin, M. A., Leong, M. L. L., Bahjat, K. S., Gao, Y. Q., Luckett, W. S., Liu, W., Cook, D. N., Portnoy, D. A., & Dubensky, T. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406035101 · Cited by 299 · see citing works

Two Listeria monocytogenes Vaccine Vectors That Express Different Molecular Forms of Human Papilloma Virus-16 (HPV-16) E7 Induce Qualitatively Different T Cell Immunity That Correlates with Their Ability to Induce Regression of Established Tumors Immortalized by HPV-16

Gunn, G. R., Zubair, A. C., Peters, C., Pan, Z.-K., Wu, T.-C., & Paterson, Y. Y. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6471 · Cited by 298 · see citing works

Genomically encoded analog memory with precise in vivo DNA writing in living cell populations

Farzadfard, F., & Lu, T. K. (2014) · Science · doi:10.1126/science.1256272 · Cited by 298 · see citing works

The turnover and shedding of epithelial cells

Creamer, B., Shorter, R. G., & Bamforth, J. S. (1961) · Gut · doi:10.1136/gut.2.2.110 · Cited by 297 · see citing works

Fast track assembly of multigene constructs using Golden Gate cloning and the MoClo system

Werner, S., Engler, C., Weber, E., Gruetzner, R., & Marillonnet, S. (2012) · Bioengineered · doi:10.4161/bbug.3.1.18223 · Cited by 293 · see citing works

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

Vandenbroucke, K., de Haard, H., Beirnaert, E., Dreier, T., Lauwereys, M., Huyck, L., Huysse, J. V., Demetter, P., Steidler, L., Remaut, E., et al. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.116 · Cited by 289 · see citing works

Design, synthesis, and testing toward a 57-codon genome

Ostrov, N., Landon, M., Güell, M., Kuznetsov, G., Teramoto, J., Cervantes, N., Zhou, M. H., Singh, K., Napolitano, M. G., Moosburner, M., et al. (2016) · Science · doi:10.1126/science.aaf3639 · Cited by 289 · see citing works

Attenuated Shigella as a DNA Delivery Vehicle for DNA-Mediated Immunization

Sizemore, D. R., Branstrom, A. A., & SADOFF, J. C. (1995) · Science · doi:10.1126/science.270.5234.299 · Cited by 286 · see citing works

Short hairpin RNA–expressing bacteria elicit RNA interference in mammals

Xiang, S., Fruehauf, J. H., & Li, C. J. (2006) · Nature Biotechnology · doi:10.1038/nbt1211 · Cited by 282 · see citing works

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

Chen, Z., Guo, L., Zhang, Y., L. Walzem, R., Pendergast, J. S., Printz, R. L., Morris, L. C., Matafonova, E., Stien, X., Kang, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72517 · Cited by 277 · see citing works

Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice

Vandenbroucke, K., Hans, W., Van Huysse, J., Neirynck, S., Demetter, P., Remaut, E., Rottiers, P., & Steidler, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.020 · Cited by 277 · see citing works

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon γ

Tilg, H., van Montfrans, C., van den Ende, A., Kaser, A., van Deventer, S. J. H., Schreiber, S., Gregor, M., Ludwiczek, O., Rutgeerts, P., Gasché, C., et al. (2002) · Gut · doi:10.1136/gut.50.2.191 · Cited by 273 · see citing works

Tunable thermal bioswitches for in vivo control of microbial therapeutics

Piraner, D. I., Abedi, M. H., Moser, B., Lee‐Gosselin, A., & Shapiro, M. G. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2233 · Cited by 266 · see citing works

Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes

Duan, F. F., Liu, J. H., & March, J. C. (2015) · Diabetes · doi:10.2337/db14-0635 · Cited by 263 · see citing works

Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates

Courbet, A., Endy, D., Renard, É., Molina, F., & Bonnet, J. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3601 · Cited by 262 · see citing works

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

Motta, J.-P., Bermúdez-Humarán, L. G., Deraison, C., Martin, L., Rolland, C., Rousset, P., Boue, J., Dietrich, G., Chapman, K., Kharrat, P., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004212 · Cited by 257 · see citing works

Tunable protein degradation in bacteria

Cameron, D. E., & Collins, J. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.3053 · Cited by 255 · see citing works

Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model

Duan, F., & March, J. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001294107 · Cited by 248 · see citing works

Synthetic recombinase-based state machines in living cells

Roquet, N., Soleimany, A. P., Ferris, A. C., Aaronson, S., & Lu, T. K. (2016) · Science · doi:10.1126/science.aad8559 · Cited by 245 · see citing works

Tunable Expression Tools Enable Single-Cell Strain Distinction in the Gut Microbiome

Whitaker, W. R., Shepherd, E. S., & Sonnenburg, J. L. (2017) · Cell · doi:10.1016/j.cell.2017.03.041 · Cited by 244 · see citing works

Permanent genetic memory with &gt;1-byte capacity

Yang, L., Nielsen, A. A. K., Fernandez-Rodriguez, J., McClune, C. J., Laub, M. T., Lu, T. K., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.3147 · Cited by 243 · see citing works

An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk

Yissachar, N., Zhou, Y., Ung, L., Lai, N. Y., Mohan, J. F., Ehrlicher, A., Weitz, D. A., Kasper, D. L., Chiu, I. M., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.009 · Cited by 242 · see citing works

Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

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